IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence

IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show tha...

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Published inNature communications Vol. 13; no. 1; pp. 874 - 19
Main Authors Chiang, Hung-Yu, Lu, Hsueh-Han, Sudhakar, Janaki N., Chen, Yu-Wen, Shih, Nien-Shin, Weng, Yi-Ting, Shui, Jr-Wen
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 15.02.2022
Nature Publishing Group
Nature Portfolio
Subjects
13/100
13/106
13/21
13/31
13/95
14/19
38/15
631/250/127/1213
631/250/2499
631/250/254
631/250/347
AKT protein
Animals
Antiinfectives and antibacterials
Budding
Cell culture
Circuits
Crohn Disease - microbiology
Crohn Disease - pathology
Cytokines
Dysbiosis - microbiology
E coli
Epithelial cells
Epithelium
Escherichia coli - immunology
Escherichia coli Infections - immunology
Gene expression
Genes
Goblet cells
Humanities and Social Sciences
Immunity, Mucosal - immunology
Interferon-gamma - immunology
Interleukin 18
Interleukin 22
Interleukin-18 - genetics
Interleukin-18 - immunology
Interleukins - immunology
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestine
Lymphocytes
Lymphocytes T
Lysozyme
Mice
Mice, Inbred C57BL
Mice, Knockout
Microorganisms
multidisciplinary
Muramidase - metabolism
Organoids
Paneth cells
Paneth Cells - immunology
Promoter Regions, Genetic - genetics
Science
Science (multidisciplinary)
Signaling
Stat3 protein
STAT3 Transcription Factor - metabolism
Stem cell transplantation
Stem cells
Tight Junctions - immunology
γ-Interferon
Online AccessGet full text
ISSN2041-1723
2041-1723
DOI10.1038/s41467-022-28478-3

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Abstract IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5 + stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme + Paneth cells in Il-22 −/− mice, but IL-22 administration fails to restore these parameters in Il-18 −/− mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5 + stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ + T cells. IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5 + stem cell expansion via Tcf4.
AbstractList IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5 stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme Paneth cells in Il-22 mice, but IL-22 administration fails to restore these parameters in Il-18 mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5 stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ T cells.
IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5+ stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme+ Paneth cells in Il-22-/- mice, but IL-22 administration fails to restore these parameters in Il-18-/- mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5+ stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme+ Paneth cells in Il-22-/- mice, but IL-22 administration fails to restore these parameters in Il-18-/- mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.
IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5 + stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme + Paneth cells in Il-22 −/− mice, but IL-22 administration fails to restore these parameters in Il-18 −/− mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5 + stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ + T cells. IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5 + stem cell expansion via Tcf4.
IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5+ stem cell expansion via Tcf4.
IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5 + stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme + Paneth cells in Il-22 −/− mice, but IL-22 administration fails to restore these parameters in Il-18 −/− mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5 + stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ + T cells.
IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In contrast to its known role in Goblet cells, regulation of barrier function at the molecular level by IL-18 is much less explored. Here we show that IL-18 is a bona fide IL-22-regulated gate keeper for intestinal epithelial barrier. IL-22 promotes crypt immunity both via induction of phospho-Stat3 binding to the Il-18 gene promoter and via Il-18 independent mechanisms. In organoid culture, while IL-22 primarily increases organoid size and inhibits expression of stem cell genes, IL-18 preferentially promotes organoid budding and induces signature genes of Lgr5+ stem cells via Akt-Tcf4 signalling. During adherent-invasive E. coli (AIEC) infection, systemic administration of IL-18 corrects compromised T-cell IFNγ production and restores Lysozyme+ Paneth cells in Il-22−/− mice, but IL-22 administration fails to restore these parameters in Il-18−/− mice, thereby placing IL-22-Stat3 signalling upstream of the IL-18-mediated barrier defence function. IL-18 in return regulates Stat3-mediated anti-microbial response in Paneth cells, Akt-Tcf4-triggered expansion of Lgr5+ stem cells to facilitate tissue repair, and AIEC clearance by promoting IFNγ+ T cells.IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E. coli invasion, inducing expression of anti-microbial genes in Paneth cells via Stat3, prompting IFNγ expression in T cells and triggering intestinal Lgr5+ stem cell expansion via Tcf4.
ArticleNumber 874
Author Weng, Yi-Ting
Lu, Hsueh-Han
Chen, Yu-Wen
Shui, Jr-Wen
Chiang, Hung-Yu
Sudhakar, Janaki N.
Shih, Nien-Shin
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35169117$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/ncomms2957
10.1038/nature16460
10.1016/j.cellsig.2019.109388
10.1038/ncomms8166
10.1016/j.ejim.2004.11.008
10.1016/j.jcmgh.2018.06.008
10.1053/j.gastro.2004.04.061
10.1038/nature07935
10.1002/stem.1233
10.1016/j.immuni.2015.01.011
10.1136/gutjnl-2017-314903
10.1136/gut.2008.163667
10.1124/pr.119.018440
10.1371/journal.pone.0084553
10.1016/j.jcmgh.2018.09.006
10.4331/wjbc.v11.i1.1
10.1084/jem.20082683
10.4049/jimmunol.179.5.3109
10.1073/pnas.0907722106
10.1038/nature11582
10.1016/j.stem.2012.09.009
10.1016/j.cell.2019.12.016
10.1158/1535-7163.MCT-09-1012
10.1038/s41385-020-00348-5
10.1053/j.gastro.2006.08.039
10.3389/fimmu.2017.01204
10.1126/sciimmunol.abd2876
10.1016/j.cell.2015.10.048
10.3748/wjg.v21.i28.8711
10.1097/MOG.0b013e32834c453e
10.1053/j.gastro.2011.07.050
10.1038/nm1720
10.18632/oncotarget.8465
10.1038/nrm3721
10.1371/journal.ppat.1003698
10.1038/s41419-019-1540-2
10.1002/ibd.20272
10.1084/jem.192.9.1365
10.3390/ijms20030649
10.1152/ajpgi.00453.2010
10.1038/emboj.2012.149
10.1242/dev.070763
10.1016/j.cell.2015.10.072
10.1128/MCB.06288-11
10.1016/j.crohns.2010.05.010
10.1111/liv.14747
10.1038/nature12599
10.1038/nprot.2015.047
10.1126/science.aah5903
10.1038/nature10209
10.1038/1270
10.1053/j.gastro.2012.02.006
10.1371/journal.pone.0004496
10.1053/j.gastro.2007.11.059
10.1038/ncb1240
10.1007/s00535-017-1401-7
10.1128/MCB.24.22.9736-9743.2004
10.1016/j.cell.2009.01.031
10.1126/science.1234852
10.4049/jimmunol.163.1.143
10.4049/jimmunol.162.11.6829
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References Barker, van Oudenaarden, Clevers (CR35) 2012; 11
Zheng (CR58) 2008; 14
Bharadwaj, Kasembeli, Robinson, Tweardy (CR57) 2020; 72
Zhang (CR13) 2020; 5
Pizarro (CR46) 1999; 162
von Furstenberg (CR24) 2011; 300
Wehkamp (CR53) 2007; 179
Pelczar (CR9) 2016; 354
VanDussen (CR27) 2012; 139
Armbruster, Stange, Wehkamp (CR51) 2017; 8
Nowarski (CR14) 2015; 163
Petnicki-Ocwieja (CR30) 2009; 106
Mizoguchi (CR8) 2018; 53
Sartor (CR22) 2008; 134
Kawasaki (CR36) 2021; 41
Saebo, Vik, Lange, Matuszkiewicz (CR2) 2005; 16
Zeng (CR7) 2019; 10
Jostins (CR1) 2012; 491
Monteleone (CR19) 1999; 163
Gao (CR21) 2015; 21
Zhao (CR40) 2015; 6
van Es (CR50) 2012; 32
Zha (CR17) 2019; 7
Barker (CR25) 2014; 15
Small, Reid-Yu, McPhee, Coombes (CR5) 2013; 4
Pickert (CR28) 2009; 206
Mann, Saeed (CR4) 2012; 28
Schuijers, Clevers (CR33) 2012; 31
Sato (CR55) 2009; 459
Khor, Gardet, Xavier (CR23) 2011; 474
Camprubi-Font, Martinez-Medina (CR45) 2020; 11
Gaudino (CR18) 2021; 14
Wehkamp, Stange (CR56) 2010; 4
Darfeuille-Michaud (CR3) 2004; 127
Kemper (CR47) 2012; 30
Jarret (CR43) 2020; 180
Levy (CR12) 2015; 163
Rothenberg (CR31) 2012; 142
Muhl, Bachmann (CR29) 2019; 63
van Es (CR48) 2005; 7
Koslowski (CR52) 2009; 4
Yasuda, Nakanishi, Tsutsui (CR10) 2019; 20
Palmela (CR44) 2018; 67
van der Flier (CR26) 2009; 136
Van der Flier (CR39) 2007; 132
Morita (CR49) 2004; 24
Karanu (CR34) 2000; 192
Sato (CR61) 2011; 141
Adolph (CR59) 2013; 503
Walker (CR54) 2013; 8
Brand (CR6) 2009; 58
Munoz (CR11) 2015; 42
Leach (CR20) 2008; 14
Hirai (CR41) 2010; 9
Turner, Stockinger, Helmby (CR42) 2013; 9
Lindemans (CR15) 2015; 528
Moro, Ealey, Kabata, Koyasu (CR60) 2015; 10
Jia (CR37) 2016; 7
Korinek (CR38) 1998; 19
Zwarycz (CR16) 2019; 7
Sato, Clevers (CR32) 2013; 340
J Jia (28478_CR37) 2016; 7
LG van der Flier (28478_CR26) 2009; 136
JE Turner (28478_CR42) 2013; 9
J Wehkamp (28478_CR53) 2007; 179
M Munoz (28478_CR11) 2015; 42
R Nowarski (28478_CR14) 2015; 163
B Zwarycz (28478_CR16) 2019; 7
T Petnicki-Ocwieja (28478_CR30) 2009; 106
J Schuijers (28478_CR33) 2012; 31
G Pickert (28478_CR28) 2009; 206
TT Pizarro (28478_CR46) 1999; 162
A Mizoguchi (28478_CR8) 2018; 53
KL VanDussen (28478_CR27) 2012; 139
NS Armbruster (28478_CR51) 2017; 8
SJ Gaudino (28478_CR18) 2021; 14
A Saebo (28478_CR2) 2005; 16
JM Zha (28478_CR17) 2019; 7
SJ Gao (28478_CR21) 2015; 21
T Sato (28478_CR32) 2013; 340
Y Zheng (28478_CR58) 2008; 14
C Camprubi-Font (28478_CR45) 2020; 11
H Hirai (28478_CR41) 2010; 9
P Pelczar (28478_CR9) 2016; 354
EA Mann (28478_CR4) 2012; 28
G Monteleone (28478_CR19) 1999; 163
JH van Es (28478_CR50) 2012; 32
T Sato (28478_CR55) 2009; 459
CR Walker (28478_CR54) 2013; 8
B Zeng (28478_CR7) 2019; 10
H Muhl (28478_CR29) 2019; 63
K Kemper (28478_CR47) 2012; 30
JH van Es (28478_CR48) 2005; 7
CA Lindemans (28478_CR15) 2015; 528
N Barker (28478_CR25) 2014; 15
A Jarret (28478_CR43) 2020; 180
LG Van der Flier (28478_CR39) 2007; 132
K Kawasaki (28478_CR36) 2021; 41
RJ von Furstenberg (28478_CR24) 2011; 300
CL Small (28478_CR5) 2013; 4
U Bharadwaj (28478_CR57) 2020; 72
T Sato (28478_CR61) 2011; 141
A Darfeuille-Michaud (28478_CR3) 2004; 127
FN Karanu (28478_CR34) 2000; 192
C Palmela (28478_CR44) 2018; 67
ME Rothenberg (28478_CR31) 2012; 142
V Korinek (28478_CR38) 1998; 19
B Khor (28478_CR23) 2011; 474
Z Zhang (28478_CR13) 2020; 5
RB Sartor (28478_CR22) 2008; 134
H Morita (28478_CR49) 2004; 24
MJ Koslowski (28478_CR52) 2009; 4
J Wehkamp (28478_CR56) 2010; 4
ST Leach (28478_CR20) 2008; 14
TE Adolph (28478_CR59) 2013; 503
L Jostins (28478_CR1) 2012; 491
S Brand (28478_CR6) 2009; 58
K Moro (28478_CR60) 2015; 10
M Levy (28478_CR12) 2015; 163
K Yasuda (28478_CR10) 2019; 20
N Barker (28478_CR35) 2012; 11
B Zhao (28478_CR40) 2015; 6
References_xml – volume: 4
  year: 2013
  ident: CR5
  article-title: Persistent infection with Crohn’s disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2957
– volume: 528
  start-page: 560
  year: 2015
  end-page: 564
  ident: CR15
  article-title: Interleukin-22 promotes intestinal-stem-cell-mediated epithelial regeneration
  publication-title: Nature
  doi: 10.1038/nature16460
– volume: 63
  start-page: 109388
  year: 2019
  ident: CR29
  article-title: IL-18/IL-18BP and IL-22/IL-22BP: Two interrelated couples with therapeutic potential
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2019.109388
– volume: 6
  year: 2015
  ident: CR40
  article-title: The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+ stem cells
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8166
– volume: 16
  start-page: 176
  year: 2005
  end-page: 182
  ident: CR2
  article-title: Inflammatory bowel disease associated with Yersinia enterocolitica O:3 infection
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2004.11.008
– volume: 7
  start-page: 1
  year: 2019
  end-page: 17
  ident: CR16
  article-title: IL22 inhibits epithelial stem cell expansion in an ileal organoid model
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2018.06.008
– volume: 127
  start-page: 412
  year: 2004
  end-page: 421
  ident: CR3
  article-title: High prevalence of adherent-invasive Escherichia coli associated with ileal mucosa in Crohn’s disease
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.04.061
– volume: 459
  start-page: 262
  year: 2009
  end-page: 265
  ident: CR55
  article-title: Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
  publication-title: Nature
  doi: 10.1038/nature07935
– volume: 30
  start-page: 2378
  year: 2012
  end-page: 2386
  ident: CR47
  article-title: Monoclonal antibodies against Lgr5 identify human colorectal cancer stem cells
  publication-title: Stem Cells
  doi: 10.1002/stem.1233
– volume: 42
  start-page: 321
  year: 2015
  end-page: 331
  ident: CR11
  article-title: Interleukin-22 induces interleukin-18 expression from epithelial cells during intestinal infection
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.01.011
– volume: 67
  start-page: 574
  year: 2018
  end-page: 587
  ident: CR44
  article-title: Adherent-invasive Escherichia coli in inflammatory bowel disease
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-314903
– volume: 58
  start-page: 1152
  year: 2009
  end-page: 1167
  ident: CR6
  article-title: Crohn’s disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn’s disease
  publication-title: Gut
  doi: 10.1136/gut.2008.163667
– volume: 72
  start-page: 486
  year: 2020
  end-page: 526
  ident: CR57
  article-title: Targeting Janus Kinases and Signal Transducer and Activator of Transcription 3 to Treat Inflammation, Fibrosis, and Cancer: Rationale, Progress, and Caution
  publication-title: Pharm. Rev.
  doi: 10.1124/pr.119.018440
– volume: 8
  start-page: e84553
  year: 2013
  ident: CR54
  article-title: Intestinal intraepithelial lymphocyte-enterocyte crosstalk regulates production of bactericidal angiogenin 4 by Paneth cells upon microbial challenge
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0084553
– volume: 7
  start-page: 255
  year: 2019
  end-page: 274
  ident: CR17
  article-title: Interleukin 22 expands transit-amplifying cells while depleting lgr5(+) stem cells via inhibition of Wnt and notch signaling
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2018.09.006
– volume: 11
  start-page: 1
  year: 2020
  end-page: 13
  ident: CR45
  article-title: Why the discovery of adherent-invasive Escherichia coli molecular markers is so challenging?
  publication-title: World J. Biol. Chem.
  doi: 10.4331/wjbc.v11.i1.1
– volume: 206
  start-page: 1465
  year: 2009
  end-page: 1472
  ident: CR28
  article-title: STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
  publication-title: J. Exp. Med
  doi: 10.1084/jem.20082683
– volume: 179
  start-page: 3109
  year: 2007
  end-page: 3118
  ident: CR53
  article-title: The Paneth cell alpha-defensin deficiency of ileal Crohn’s disease is linked to Wnt/Tcf-4
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.5.3109
– volume: 106
  start-page: 15813
  year: 2009
  end-page: 15818
  ident: CR30
  article-title: Nod2 is required for the regulation of commensal microbiota in the intestine
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0907722106
– volume: 491
  start-page: 119
  year: 2012
  end-page: 124
  ident: CR1
  article-title: Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease
  publication-title: Nature
  doi: 10.1038/nature11582
– volume: 11
  start-page: 452
  year: 2012
  end-page: 460
  ident: CR35
  article-title: Identifying the stem cell of the intestinal crypt: strategies and pitfalls
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.09.009
– volume: 180
  start-page: 50
  year: 2020
  end-page: 63
  ident: CR43
  article-title: Enteric nervous system-derived IL-18 orchestrates mucosal barrier immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.016
– volume: 163
  start-page: 143
  year: 1999
  end-page: 147
  ident: CR19
  article-title: Bioactive IL-18 expression is up-regulated in Crohn’s disease
  publication-title: J. Immunol.
– volume: 9
  start-page: 1956
  year: 2010
  end-page: 1967
  ident: CR41
  article-title: MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-09-1012
– volume: 14
  start-page: 389
  year: 2021
  end-page: 401
  ident: CR18
  article-title: IL-22 receptor signaling in Paneth cells is critical for their maturation, microbiota colonization, Th17-related immune responses, and anti-Salmonella immunity
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-020-00348-5
– volume: 132
  start-page: 628
  year: 2007
  end-page: 632
  ident: CR39
  article-title: The Intestinal Wnt/TCF Signature
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.08.039
– volume: 8
  start-page: 1204
  year: 2017
  ident: CR51
  article-title: In the Wnt of Paneth Cells: Immune-Epithelial Crosstalk in Small Intestinal Crohn’s Disease
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01204
– volume: 5
  start-page: eabd2876
  year: 2020
  ident: CR13
  article-title: IL-22-induced cell extrusion and IL-18-induced cell death prevent and cure rotavirus infection
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abd2876
– volume: 163
  start-page: 1428
  year: 2015
  end-page: 1443
  ident: CR12
  article-title: Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.048
– volume: 21
  start-page: 8711
  year: 2015
  end-page: 8722
  ident: CR21
  article-title: Interleukin-18 genetic polymorphisms contribute differentially to the susceptibility to Crohn’s disease
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v21.i28.8711
– volume: 28
  start-page: 24
  year: 2012
  end-page: 29
  ident: CR4
  article-title: Gastrointestinal infection as a trigger for inflammatory bowel disease
  publication-title: Curr. Opin. Gastroenterol.
  doi: 10.1097/MOG.0b013e32834c453e
– volume: 141
  start-page: 1762
  year: 2011
  end-page: 1772
  ident: CR61
  article-title: Long-term expansion of epithelial organoids from human colon, adenoma, adenocarcinoma, and Barrett’s epithelium
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.07.050
– volume: 14
  start-page: 282
  year: 2008
  end-page: 289
  ident: CR58
  article-title: Interleukin-22 mediates early host defense against attaching and effacing bacterial pathogens
  publication-title: Nat. Med
  doi: 10.1038/nm1720
– volume: 7
  start-page: 27280
  year: 2016
  end-page: 27294
  ident: CR37
  article-title: LGR5 expression is controled by IKKα in basal cell carcinoma through activating STAT3 signaling pathway
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8465
– volume: 15
  start-page: 19
  year: 2014
  end-page: 33
  ident: CR25
  article-title: Adult intestinal stem cells: critical drivers of epithelial homeostasis and regeneration
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3721
– volume: 162
  start-page: 6829
  year: 1999
  end-page: 6835
  ident: CR46
  article-title: IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn’s disease: expression and localization in intestinal mucosal cells
  publication-title: J. Immunol.
– volume: 9
  start-page: e1003698
  year: 2013
  ident: CR42
  article-title: IL-22 mediates goblet cell hyperplasia and worm expulsion in intestinal helminth infection
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003698
– volume: 10
  year: 2019
  ident: CR7
  article-title: ILC3 function as a double-edged sword in inflammatory bowel diseases
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-1540-2
– volume: 14
  start-page: 68
  year: 2008
  end-page: 74
  ident: CR20
  article-title: Local and systemic interleukin-18 and interleukin-18-binding protein in children with inflammatory bowel disease
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1002/ibd.20272
– volume: 192
  start-page: 1365
  year: 2000
  end-page: 1372
  ident: CR34
  article-title: The notch ligand jagged-1 represents a novel growth factor of human hematopoietic stem cells
  publication-title: J. Exp. Med
  doi: 10.1084/jem.192.9.1365
– volume: 20
  start-page: 649
  year: 2019
  ident: CR10
  article-title: Interleukin-18 in health and disease
  publication-title: Int J. Mol. Sci.
  doi: 10.3390/ijms20030649
– volume: 300
  start-page: G409
  year: 2011
  end-page: G417
  ident: CR24
  article-title: Sorting mouse jejunal epithelial cells with CD24 yields a population with characteristics of intestinal stem cells
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00453.2010
– volume: 31
  start-page: 2685
  year: 2012
  end-page: 2696
  ident: CR33
  article-title: Adult mammalian stem cells: the role of Wnt, Lgr5 and R-spondins
  publication-title: EMBO J.
  doi: 10.1038/emboj.2012.149
– volume: 139
  start-page: 488
  year: 2012
  end-page: 497
  ident: CR27
  article-title: Notch signaling modulates proliferation and differentiation of intestinal crypt base columnar stem cells
  publication-title: Development
  doi: 10.1242/dev.070763
– volume: 163
  start-page: 1444
  year: 2015
  end-page: 1456
  ident: CR14
  article-title: Epithelial IL-18 equilibrium controls barrier function in colitis
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.072
– volume: 32
  start-page: 1918
  year: 2012
  end-page: 1927
  ident: CR50
  article-title: A critical role for the Wnt effector Tcf4 in adult intestinal homeostatic self-renewal
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.06288-11
– volume: 4
  start-page: 523
  year: 2010
  end-page: 531
  ident: CR56
  article-title: Paneth’s disease
  publication-title: J. Crohns Colitis
  doi: 10.1016/j.crohns.2010.05.010
– volume: 41
  start-page: 865
  year: 2021
  end-page: 881
  ident: CR36
  article-title: LGR5 induces beta-catenin activation and augments tumour progression by activating STAT3 in human intrahepatic cholangiocarcinoma
  publication-title: Liver Int
  doi: 10.1111/liv.14747
– volume: 503
  start-page: 272
  year: 2013
  end-page: 276
  ident: CR59
  article-title: Paneth cells as a site of origin for intestinal inflammation
  publication-title: Nature
  doi: 10.1038/nature12599
– volume: 10
  start-page: 792
  year: 2015
  end-page: 806
  ident: CR60
  article-title: Isolation and analysis of group 2 innate lymphoid cells in mice
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.047
– volume: 354
  start-page: 358
  year: 2016
  end-page: 362
  ident: CR9
  article-title: A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease
  publication-title: Science
  doi: 10.1126/science.aah5903
– volume: 474
  start-page: 307
  year: 2011
  end-page: 317
  ident: CR23
  article-title: Genetics and pathogenesis of inflammatory bowel disease
  publication-title: Nature
  doi: 10.1038/nature10209
– volume: 19
  start-page: 379
  year: 1998
  end-page: 383
  ident: CR38
  article-title: Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
  publication-title: Nat. Genet
  doi: 10.1038/1270
– volume: 142
  start-page: 1195
  year: 2012
  end-page: 1205 e1196
  ident: CR31
  article-title: Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.02.006
– volume: 4
  start-page: e4496
  year: 2009
  ident: CR52
  article-title: Genetic variants of Wnt transcription factor TCF-4 (TCF7L2) putative promoter region are associated with small intestinal Crohn’s disease
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0004496
– volume: 134
  start-page: 577
  year: 2008
  end-page: 594
  ident: CR22
  article-title: Microbial influences in inflammatory bowel diseases
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.11.059
– volume: 7
  start-page: 381
  year: 2005
  end-page: 386
  ident: CR48
  article-title: Wnt signalling induces maturation of Paneth cells in intestinal crypts
  publication-title: Nat. cell Biol.
  doi: 10.1038/ncb1240
– volume: 53
  start-page: 465
  year: 2018
  end-page: 474
  ident: CR8
  article-title: Clinical importance of IL-22 cascade in IBD
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-017-1401-7
– volume: 24
  start-page: 9736
  year: 2004
  end-page: 9743
  ident: CR49
  article-title: Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.24.22.9736-9743.2004
– volume: 136
  start-page: 903
  year: 2009
  end-page: 912
  ident: CR26
  article-title: Transcription factor achaete scute-like 2 controls intestinal stem cell fate
  publication-title: Cell
  doi: 10.1016/j.cell.2009.01.031
– volume: 340
  start-page: 1190
  year: 2013
  end-page: 1194
  ident: CR32
  article-title: Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applications
  publication-title: Science
  doi: 10.1126/science.1234852
– volume: 8
  start-page: e84553
  year: 2013
  ident: 28478_CR54
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0084553
– volume: 42
  start-page: 321
  year: 2015
  ident: 28478_CR11
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.01.011
– volume: 72
  start-page: 486
  year: 2020
  ident: 28478_CR57
  publication-title: Pharm. Rev.
  doi: 10.1124/pr.119.018440
– volume: 53
  start-page: 465
  year: 2018
  ident: 28478_CR8
  publication-title: J. Gastroenterol.
  doi: 10.1007/s00535-017-1401-7
– volume: 106
  start-page: 15813
  year: 2009
  ident: 28478_CR30
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0907722106
– volume: 41
  start-page: 865
  year: 2021
  ident: 28478_CR36
  publication-title: Liver Int
  doi: 10.1111/liv.14747
– volume: 7
  start-page: 1
  year: 2019
  ident: 28478_CR16
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2018.06.008
– volume: 11
  start-page: 452
  year: 2012
  ident: 28478_CR35
  publication-title: Cell Stem Cell
  doi: 10.1016/j.stem.2012.09.009
– volume: 6
  year: 2015
  ident: 28478_CR40
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8166
– volume: 180
  start-page: 50
  year: 2020
  ident: 28478_CR43
  publication-title: Cell
  doi: 10.1016/j.cell.2019.12.016
– volume: 179
  start-page: 3109
  year: 2007
  ident: 28478_CR53
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.179.5.3109
– volume: 21
  start-page: 8711
  year: 2015
  ident: 28478_CR21
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v21.i28.8711
– volume: 14
  start-page: 282
  year: 2008
  ident: 28478_CR58
  publication-title: Nat. Med
  doi: 10.1038/nm1720
– volume: 67
  start-page: 574
  year: 2018
  ident: 28478_CR44
  publication-title: Gut
  doi: 10.1136/gutjnl-2017-314903
– volume: 354
  start-page: 358
  year: 2016
  ident: 28478_CR9
  publication-title: Science
  doi: 10.1126/science.aah5903
– volume: 32
  start-page: 1918
  year: 2012
  ident: 28478_CR50
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.06288-11
– volume: 300
  start-page: G409
  year: 2011
  ident: 28478_CR24
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00453.2010
– volume: 9
  start-page: e1003698
  year: 2013
  ident: 28478_CR42
  publication-title: PLoS Pathog.
  doi: 10.1371/journal.ppat.1003698
– volume: 30
  start-page: 2378
  year: 2012
  ident: 28478_CR47
  publication-title: Stem Cells
  doi: 10.1002/stem.1233
– volume: 11
  start-page: 1
  year: 2020
  ident: 28478_CR45
  publication-title: World J. Biol. Chem.
  doi: 10.4331/wjbc.v11.i1.1
– volume: 4
  year: 2013
  ident: 28478_CR5
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms2957
– volume: 7
  start-page: 27280
  year: 2016
  ident: 28478_CR37
  publication-title: Oncotarget
  doi: 10.18632/oncotarget.8465
– volume: 4
  start-page: 523
  year: 2010
  ident: 28478_CR56
  publication-title: J. Crohns Colitis
  doi: 10.1016/j.crohns.2010.05.010
– volume: 10
  year: 2019
  ident: 28478_CR7
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-019-1540-2
– volume: 139
  start-page: 488
  year: 2012
  ident: 28478_CR27
  publication-title: Development
  doi: 10.1242/dev.070763
– volume: 127
  start-page: 412
  year: 2004
  ident: 28478_CR3
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2004.04.061
– volume: 8
  start-page: 1204
  year: 2017
  ident: 28478_CR51
  publication-title: Front Immunol.
  doi: 10.3389/fimmu.2017.01204
– volume: 7
  start-page: 381
  year: 2005
  ident: 28478_CR48
  publication-title: Nat. cell Biol.
  doi: 10.1038/ncb1240
– volume: 192
  start-page: 1365
  year: 2000
  ident: 28478_CR34
  publication-title: J. Exp. Med
  doi: 10.1084/jem.192.9.1365
– volume: 503
  start-page: 272
  year: 2013
  ident: 28478_CR59
  publication-title: Nature
  doi: 10.1038/nature12599
– volume: 10
  start-page: 792
  year: 2015
  ident: 28478_CR60
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2015.047
– volume: 31
  start-page: 2685
  year: 2012
  ident: 28478_CR33
  publication-title: EMBO J.
  doi: 10.1038/emboj.2012.149
– volume: 134
  start-page: 577
  year: 2008
  ident: 28478_CR22
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2007.11.059
– volume: 163
  start-page: 1444
  year: 2015
  ident: 28478_CR14
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.072
– volume: 28
  start-page: 24
  year: 2012
  ident: 28478_CR4
  publication-title: Curr. Opin. Gastroenterol.
  doi: 10.1097/MOG.0b013e32834c453e
– volume: 4
  start-page: e4496
  year: 2009
  ident: 28478_CR52
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0004496
– volume: 340
  start-page: 1190
  year: 2013
  ident: 28478_CR32
  publication-title: Science
  doi: 10.1126/science.1234852
– volume: 163
  start-page: 143
  year: 1999
  ident: 28478_CR19
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.163.1.143
– volume: 14
  start-page: 68
  year: 2008
  ident: 28478_CR20
  publication-title: Inflamm. Bowel Dis.
  doi: 10.1002/ibd.20272
– volume: 5
  start-page: eabd2876
  year: 2020
  ident: 28478_CR13
  publication-title: Sci. Immunol.
  doi: 10.1126/sciimmunol.abd2876
– volume: 142
  start-page: 1195
  year: 2012
  ident: 28478_CR31
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2012.02.006
– volume: 206
  start-page: 1465
  year: 2009
  ident: 28478_CR28
  publication-title: J. Exp. Med
  doi: 10.1084/jem.20082683
– volume: 24
  start-page: 9736
  year: 2004
  ident: 28478_CR49
  publication-title: Mol. Cell Biol.
  doi: 10.1128/MCB.24.22.9736-9743.2004
– volume: 7
  start-page: 255
  year: 2019
  ident: 28478_CR17
  publication-title: Cell Mol. Gastroenterol. Hepatol.
  doi: 10.1016/j.jcmgh.2018.09.006
– volume: 491
  start-page: 119
  year: 2012
  ident: 28478_CR1
  publication-title: Nature
  doi: 10.1038/nature11582
– volume: 16
  start-page: 176
  year: 2005
  ident: 28478_CR2
  publication-title: Eur. J. Intern. Med.
  doi: 10.1016/j.ejim.2004.11.008
– volume: 15
  start-page: 19
  year: 2014
  ident: 28478_CR25
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/nrm3721
– volume: 162
  start-page: 6829
  year: 1999
  ident: 28478_CR46
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.162.11.6829
– volume: 14
  start-page: 389
  year: 2021
  ident: 28478_CR18
  publication-title: Mucosal Immunol.
  doi: 10.1038/s41385-020-00348-5
– volume: 9
  start-page: 1956
  year: 2010
  ident: 28478_CR41
  publication-title: Mol. Cancer Ther.
  doi: 10.1158/1535-7163.MCT-09-1012
– volume: 459
  start-page: 262
  year: 2009
  ident: 28478_CR55
  publication-title: Nature
  doi: 10.1038/nature07935
– volume: 163
  start-page: 1428
  year: 2015
  ident: 28478_CR12
  publication-title: Cell
  doi: 10.1016/j.cell.2015.10.048
– volume: 132
  start-page: 628
  year: 2007
  ident: 28478_CR39
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2006.08.039
– volume: 474
  start-page: 307
  year: 2011
  ident: 28478_CR23
  publication-title: Nature
  doi: 10.1038/nature10209
– volume: 20
  start-page: 649
  year: 2019
  ident: 28478_CR10
  publication-title: Int J. Mol. Sci.
  doi: 10.3390/ijms20030649
– volume: 528
  start-page: 560
  year: 2015
  ident: 28478_CR15
  publication-title: Nature
  doi: 10.1038/nature16460
– volume: 63
  start-page: 109388
  year: 2019
  ident: 28478_CR29
  publication-title: Cell Signal
  doi: 10.1016/j.cellsig.2019.109388
– volume: 141
  start-page: 1762
  year: 2011
  ident: 28478_CR61
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2011.07.050
– volume: 19
  start-page: 379
  year: 1998
  ident: 28478_CR38
  publication-title: Nat. Genet
  doi: 10.1038/1270
– volume: 58
  start-page: 1152
  year: 2009
  ident: 28478_CR6
  publication-title: Gut
  doi: 10.1136/gut.2008.163667
– volume: 136
  start-page: 903
  year: 2009
  ident: 28478_CR26
  publication-title: Cell
  doi: 10.1016/j.cell.2009.01.031
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Snippet IL-18 is emerging as an IL-22-induced and epithelium-derived cytokine which contributes to host defence against intestinal infection and inflammation. In...
IL-22 induces IL-18 expression by intestinal epithelial cells. Authors show here that IL-18 is a key barrier maintenance factor during adherent-invasive E....
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StartPage 874
SubjectTerms 13/100
13/106
13/21
13/31
13/95
14/19
38/15
631/250/127/1213
631/250/2499
631/250/254
631/250/347
AKT protein
Animals
Antiinfectives and antibacterials
Budding
Cell culture
Circuits
Crohn Disease - microbiology
Crohn Disease - pathology
Cytokines
Dysbiosis - microbiology
E coli
Epithelial cells
Epithelium
Escherichia coli - immunology
Escherichia coli Infections - immunology
Gene expression
Genes
Goblet cells
Humanities and Social Sciences
Immunity, Mucosal - immunology
Interferon-gamma - immunology
Interleukin 18
Interleukin 22
Interleukin-18 - genetics
Interleukin-18 - immunology
Interleukins - immunology
Intestinal Mucosa - cytology
Intestinal Mucosa - immunology
Intestine
Lymphocytes
Lymphocytes T
Lysozyme
Mice
Mice, Inbred C57BL
Mice, Knockout
Microorganisms
multidisciplinary
Muramidase - metabolism
Organoids
Paneth cells
Paneth Cells - immunology
Promoter Regions, Genetic - genetics
Science
Science (multidisciplinary)
Signaling
Stat3 protein
STAT3 Transcription Factor - metabolism
Stem cell transplantation
Stem cells
Tight Junctions - immunology
γ-Interferon
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Title IL-22 initiates an IL-18-dependent epithelial response circuit to enforce intestinal host defence
URI https://link.springer.com/article/10.1038/s41467-022-28478-3
https://www.ncbi.nlm.nih.gov/pubmed/35169117
https://www.proquest.com/docview/2628900511
https://www.proquest.com/docview/2629380024
https://pubmed.ncbi.nlm.nih.gov/PMC8847568
https://doaj.org/article/163ad39d47a34b52b0cef16449725e95
Volume 13
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