Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression

• Published in: Cell reports (Cambridge) Vol. 18; no. 9; pp. 2228 - 2242
• Main Authors: Kondo, Ayano, Yamamoto, Shogo, Nakaki, Ryo, Shimamura, Teppei, Hamakubo, Takao, Sakai, Juro, Kodama, Tatsuhiko, Yoshida, Tetsuo, Aburatani, Hiroyuki, Osawa, Tsuyoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 28.02.2017; Elsevier
• Subjects: Acetate-CoA Ligase - metabolism; acyl-CoA synthetase short-chain family member 2; Animals; cancer metabolism; Cell Line, Tumor; Cell Nucleus - metabolism; Cell Proliferation - physiology; Cholesterol - metabolism; Disease Progression; epigenetics; extracellular low pH; HeLa Cells; Humans; Hydrogen-Ion Concentration; hypoxia; lacate; Mice; Mice, SCID; Neoplasms - metabolism; Neoplasms - pathology; nutrient starvation; Promoter Regions, Genetic - physiology; Protein Transport - physiology; Sterol Regulatory Element Binding Protein 2 - metabolism; sterol regulatory element-binding protein 2; tumor microenvironment; Up-Regulation - physiology; cancer metabolism; hypoxia; extracellular low pH; lacate; nutrient starvation; sterol regulatory element-binding protein 2; tumor microenvironment; acyl-CoA synthetase short-chain family member 2; epigenetics

Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia. Here, we show that extracellular acidic pH (pH 6.8) trigg...