Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression - Kondo, Ayano; Yamamoto, Shogo; Nakaki, Ryo; Shimamura, Teppei; Hamakubo, Takao; Sakai, Juro; Kodama, Tatsuhiko; Yoshida, Tetsuo; Aburatani, Hiroyuki; Osawa, Tsuyoshi (Cell reports (Cambridge), 2017)
Keywords: Acetate-CoA Ligase - metabolism; acyl-CoA synthetase short-chain family member 2; Animals; cancer metabolism; Cell Line, Tumor; Cell Nucleus - metabolism; Cell Proliferation - physiology; Cholesterol - metabolism; Disease Progression; epigenetics; extracellular low pH; HeLa Cells; Humans; Hydrogen-Ion Concentration; hypoxia; lacate; Mice; Mice, SCID; Neoplasms - metabolism; Neoplasms - pathology; nutrient starvation; Promoter Regions, Genetic - physiology; Protein Transport - physiology; Sterol Regulatory Element Binding Protein 2 - metabolism; sterol regulatory element-binding protein 2; tumor microenvironment; Up-Regulation - physiology; cancer metabolism; hypoxia; extracellular low pH; lacate; nutrient starvation; sterol regulatory element-binding protein 2; tumor microenvironment; acyl-CoA synthetase short-chain family member 2; epigenetics