The role, mechanism, and application of RNA methyltransferase METTL14 in gastrointestinal cancer

• Published in: Molecular cancer Vol. 21; no. 1; pp. 1 - 15
• Main Authors: Shi, Bin, Liu, Wei-Wei, Yang, Ke, Jiang, Guan-Min, Wang, Hao
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 16.08.2022; BioMed Central; BMC
• Subjects: Cancer; Chemoresistance; Development and progression; DNA methylation; Epigenetics; Gastrointestinal cancer; Gene expression; Genes; Genetic aspects; Lethality; Liver cancer; m6A; Malignancy; Messenger RNA; Metastases; Metastasis; Methylation; Methyltransferases; METTL14; mRNA stability; mRNA turnover; N6-methyladenosine; Phenotypes; Physiological aspects; Post-transcription; Prognosis; Review; RNA modification; Stem cells; Tumorigenesis

Gastrointestinal cancer is the most common human malignancy characterized by high lethality and poor prognosis. Emerging evidences indicate that N6-methyladenosine (m6A), the most abundant post-transcriptional modification in eukaryotes, exerts important roles in regulating mRNA metabolism including...