Mannitol-Coated Hydroxypropyl Methylcellulose as a Directly Compressible Controlled Release Excipient for Moisture-Sensitive Drugs: A Stability Perspective

• Published in: Pharmaceuticals (Basel, Switzerland) Vol. 17; no. 9; p. 1167
• Main Authors: Kang, Christina Yong Xin, Chow, Keat Theng, Lui, Yuan Siang, Salome, Antoine, Boit, Baptiste, Lefevre, Philippe, Hiew, Tze Ning, Gokhale, Rajeev, Heng, Paul Wan Sia
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.09.2024; MDPI
• Subjects: Aspirin; co-processed; Competition; Controlled release technology; Drug dosages; Excipients; Humidity; hydroxypropyl methylcellulose; Mannitol; Methylcellulose; Moisture; Moisture absorption; Moisture content; Particle size; Pharmaceutical research; Pharmaceuticals; Porous materials; stability; Water; France; Singapore; hydroxypropyl methylcellulose; aspirin; co-processed; mannitol; stability

Background/Objectives: Hydroxypropyl methylcellulose (HPMC) is one of the most commonly used hydrophilic polymers in formulations of matrix tablets for controlled release applications. However, HPMC attracts moisture and poses issues with drug stability in formulations containing moisture-sensitive...