Spatiotemporal control of engineered bacteria to express interferon-γ by focused ultrasound for tumor immunotherapy

• Published in: Nature communications Vol. 13; no. 1; p. 4468
• Main Authors: Chen, Yuhao, Du, Meng, Yuan, Zhen, Chen, Zhiyi, Yan, Fei
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.08.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/21; 13/31; 13/44; 13/51; 14/19; 14/34; 14/63; 38/35; 631/250/251/1567; 631/61/2297; 692/4028/67/1059; Anticancer properties; Bacteria; Bacteria - metabolism; Cancer immunotherapy; Controlled release; Cytokines; Engineers; Gene expression; Genes; Humanities and Social Sciences; Humans; Hyperthermia; Immune response; Immunotherapy; Immunotherapy - methods; In vivo methods and tests; Interferon; Interferon-gamma - genetics; Interferon-gamma - metabolism; multidisciplinary; Neoplasms - genetics; Neoplasms - therapy; Remote control; Science; Science (multidisciplinary); Tumors; Ultrasonic imaging; Ultrasound; γ-Interferon

Bacteria-based tumor therapy has recently attracted wide attentions due to its unique capability in targeting tumors and preferentially colonizing the core area of the tumor. Various therapeutic genes are also harbored into these engineering bacteria to enhance their anti-tumor efficacy. However, it...