Growth differentiation factor 1-induced tumour plasticity provides a therapeutic window for immunotherapy in hepatocellular carcinoma

• Published in: Nature communications Vol. 12; no. 1; pp. 7142 - 14
• Main Authors: Cheng, Wei, Li, Hao-Long, Xi, Shao-Yan, Zhang, Xiao-Feng, Zhu, Yun, Le Xing, Mo, Yan-Xuan, Li, Mei-Mei, Kong, Fan-En, Zhu, Wen-Jie, Chen, Xiao-Gang, Cui, Hui-Qing, Cao, Zhi-Ming, Gong, Yuan-Feng, Tang, Yun-Qiang, Zhang, Yan, Guan, Xin-Yuan, Ma, Ning-Fang, Liu, Ming
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 08.12.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/106; 38/109; 42/89; 49/91; 59/5; 692/4028/67/1504/1610/4029; 692/4028/67/580; 692/4028/67/71; Activin; Antigens; Biomarkers; Cancer; Carcinoma, Hepatocellular - genetics; Carcinoma, Hepatocellular - metabolism; Carcinoma, Hepatocellular - pathology; Carcinoma, Hepatocellular - therapy; Cell Differentiation; Cell Line, Tumor; Cell Plasticity - drug effects; Cell Proliferation; Ectopic expression; Epigenetics; Growth differentiation factor 1; Growth Differentiation Factor 1 - metabolism; Growth Differentiation Factor 1 - pharmacology; Hepatocellular carcinoma; Homology; Humanities and Social Sciences; Humans; Immune checkpoint inhibitors; Immunogenicity; Immunotherapy; Kinases; Liver cancer; Liver Neoplasms - metabolism; Lysine; Male; Metastases; multidisciplinary; Plastic foam; Plastic properties; Plasticity; Science; Science (multidisciplinary); Signal Transduction; Signaling; Smad2 protein; Smad2 Protein - metabolism; Smad3 Protein - metabolism; Testicular Neoplasms - metabolism; Therapeutic targets; Tumors
• ISSN: 2041-1723; 2041-1723
• DOI: 10.1038/s41467-021-27525-9

Tumour lineage plasticity is an emerging hallmark of aggressive tumours. Tumour cells usually hijack developmental signalling pathways to gain cellular plasticity and evade therapeutic targeting. In the present study, the secreted protein growth and differentiation factor 1 (GDF1) is found to be clo...