Roles of lysine-specific demethylase 1 (LSD1) in homeostasis and diseases

• Published in: Journal of biomedical science Vol. 28; no. 1; pp. 1 - 41
• Main Authors: Kim, Dongha, Kim, Keun Il, Baek, Sung Hee
• Format: Journal Article
• Language: English
• Published: Basel BioMed Central Ltd 04.06.2021; BioMed Central; BMC
• Subjects: Angiogenesis; Cancer; Cell differentiation; Differentiation; Enzymes; Epigenetics; Gene expression; Genes; Genetic aspects; Genetic transcription; Histones; Homeostasis; Hypoxia; Immunity; Inflammation; Lysine; Mesenchyme; Metabolism; Metastasis; Microenvironments; Nervous system diseases; Neurodegenerative diseases; Physiology; Proteins; Respiration; Review; Stem cells; Substrates; Thermogenesis; Transcription; Transcription factors; Tumorigenesis

Lysine-specific demethylase 1 (LSD1) targets mono- or di-methylated histone H3K4 and H3K9 as well as non-histone substrates and functions in the regulation of gene expression as a transcriptional repressor or activator. This enzyme plays a pivotal role in various physiological processes, including d...