Endogenous stimulus-powered antibiotic release from nanoreactors for a combination therapy of bacterial infections

• Published in: Nature communications Vol. 10; no. 1; pp. 4464 - 10
• Main Authors: Wu, Yang, Song, Zhiyong, Wang, Huajuan, Han, Heyou
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.10.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 13/51; 147/135; 147/143; 147/28; 631/326/22; 639/925/350/2093; 639/925/352/152; 64/60; 82/1; Animals; Anti-Bacterial Agents - metabolism; Anti-Bacterial Agents - pharmacology; Antibiotics; Bacteria; Bacteria - metabolism; Bacterial diseases; Bacterial infections; Bacterial Infections - drug therapy; Bacterial Toxins - metabolism; Biocompatibility; Calcium; Combined Modality Therapy - methods; Controlled release; Decomposition reactions; Disease Models, Animal; Drug delivery; Drug delivery systems; Drug Delivery Systems - methods; Fatty Acids; Hemolysis; Humanities and Social Sciences; Hydrogen peroxide; Hydrogen Peroxide - metabolism; Immune response; Liposomes - chemistry; Liposomes - metabolism; Mice; Mice, Inbred BALB C; multidisciplinary; Nanostructures - chemistry; Nanotechnology - methods; Oxygen - chemistry; Peroxides; Pore formation; Pores; Science; Science (multidisciplinary); Structural integrity; Survival Rate; Toxicity; Toxins; Water - chemistry

The use of an endogenous stimulus instead of external trigger has an advantage for targeted and controlled release in drug delivery. Here, we report on cascade nanoreactors for bacterial toxin-triggered antibiotic release by wrapping calcium peroxide (CaO 2 ) and antibiotic in a eutectic mixture of...