Developmental potential of aneuploid human embryos cultured beyond implantation

• Published in: Nature communications Vol. 11; no. 1; pp. 3987 - 15
• Main Authors: Shahbazi, Marta N., Wang, Tianren, Tao, Xin, Weatherbee, Bailey A. T., Sun, Li, Zhan, Yiping, Keller, Laura, Smith, Gary D., Pellicer, Antonio, Scott, Richard T., Seli, Emre, Zernicka-Goetz, Magdalena
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.08.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/100; 13/106; 13/109; 14; 14/19; 38; 38/22; 38/23; 631/136/1455; 631/136/2086/1986; 631/80/641/2002; Aneuploidy; Antigens, CD - genetics; Cadherins - genetics; Cadherins - metabolism; Cell Adhesion; Cell adhesion & migration; Cell culture; Cell cycle; Cell Cycle Checkpoints; Cell differentiation; Cell Lineage; Chromosome number; Chromosome Segregation; Chromosomes; Chromosomes, Human, Pair 16; Chromosomes, Human, Pair 21; E-cadherin; Embryo Implantation - genetics; Embryo, Mammalian; Embryonic Development; Embryos; Female; Genes, erbB-1 - genetics; Genetic screening; Genetic Testing; Humanities and Social Sciences; Humans; Implantation; Monosomy; Mosaicism; multidisciplinary; Phenotypes; Placenta; Pregnancy; Science; Science (multidisciplinary); Stem Cells; Trisomy

Aneuploidy, the presence of an abnormal number of chromosomes, is a major cause of early pregnancy loss in humans. Yet, the developmental consequences of specific aneuploidies remain unexplored. Here, we determine the extent of post-implantation development of human embryos bearing common aneuploidi...