Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader

• Published in: Nature communications Vol. 10; no. 1; pp. 852 - 10
• Main Authors: Liang, Shaolin, Kinghorn, Andrew B., Voliotis, Margaritis, Prague, Julia K., Veldhuis, Johannes D., Tsaneva-Atanasova, Krasimira, McArdle, Craig A., Li, Raymond H. W., Cass, Anthony E. G., Dhillo, Waljit S., Tanner, Julian A.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.02.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 49; 49/47; 631/1647/1888/1890; 631/92/147; 692/163/2743/2730; 692/308/575; 9/10; Aptamers; Bayesian analysis; Biological evolution; Chemical sensors; Deoxyribonucleic acid; Disorders; DNA; Electrochemical analysis; Electrochemistry; Hormones; Humanities and Social Sciences; Luteinizing hormone; multidisciplinary; Reproductive disorders; Reproductive system; Robotics; Science; Science (multidisciplinary); Spectrum analysis

Normal reproductive functioning is critically dependent on pulsatile secretion of luteinising hormone (LH). Assessment of LH pulsatility is important for the clinical diagnosis of reproductive disorders, but current methods are hampered by frequent blood sampling coupled to expensive serial immunoch...