Neuregulin-4 attenuates diabetic cardiomyopathy by regulating autophagy via the AMPK/mTOR signalling pathway

• Published in: Cardiovascular diabetology Vol. 21; no. 1; pp. 1 - 205
• Main Authors: Wang, Hongchao, Wang, Lijie, Hu, Fuli, Wang, Pengfei, Xie, Yanan, Li, Fang, Guo, Bingyan
• Format: Journal Article
• Language: English
• Published: London BioMed Central 11.10.2022; BMC
• Subjects: Apoptosis; Autophagy; Cardiomyocytes; Cardiomyopathy; Cardiovascular disease; Collagen; Diabetes; Diabetes mellitus (insulin dependent); Diabetic cardiomyopathy; Fibrosis; Glucose; Heart failure; Insulin; Insulin resistance; Medical research; Metabolic disorders; Metabolism; Neuregulin; Neuregulin-4; Signal transduction; Signalling pathway; Software; TOR protein; Ventricle; Beijing China; United States > US; China

Abstract Background Diabetic cardiomyopathy is characterized by left ventricle dysfunction, cardiomyocyte apoptosis, and interstitial fibrosis and is a serious complication of diabetes mellitus (DM). Autophagy is a mechanism that is essential for maintaining normal heart morphology and function, and...