MicroRNA 375 modulates hyperglycemia-induced enteric glial cell apoptosis and Diabetes-induced gastrointestinal dysfunction by targeting Pdk1 and repressing PI3K/Akt pathway

• Published in: Scientific reports Vol. 8; no. 1; pp. 12681 - 10
• Main Authors: Chen, Yan, Liu, Gongxiang, He, Fuqian, Zhang, Li, Yang, Kun, Yu, Huan, Zhou, Jinqiu, Gan, Huatian
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 23.08.2018; Nature Publishing Group
• Subjects: 1-Phosphatidylinositol 3-kinase; 13; 13/1; 13/109; 13/2; 13/31; 13/89; 14; 14/34; 631/378/2596; 692/4020/1503/2753; AKT protein; Apoptosis; Diabetes; Diabetes mellitus; Diabetic neuropathy; Enteric nervous system; Gastrointestinal diseases; Gene expression; Humanities and Social Sciences; Hyperglycemia; miRNA; multidisciplinary; Myenteric plexus; Nervous system; Science; Science (multidisciplinary); Streptozocin

Diabetic neuropathy can damage systemic nervous system, including alteration of enteric nervous system and subsequent gastrointestinal dysfunction. The effect of diabetes on enteric glia cell (EGC) is not clear. We investigated the effect of diabetes and hyperglycemia on EGC, and the role of microRN...