Fis1 phosphorylation by Met promotes mitochondrial fission and hepatocellular carcinoma metastasis

• Published in: Signal transduction and targeted therapy Vol. 6; no. 1; pp. 401 - 15
• Main Authors: Yu, Yan, Peng, Xiao-Dan, Qian, Xiao-Jun, Zhang, Kai-Ming, Huang, Xiang, Chen, Yu-Hong, Li, Yun-Tian, Feng, Gong-Kan, Zhang, Hai-Liang, Xu, Xue-Lian, Li, Shun, Li, Xuan, Mai, Jia, Li, Zhi-Ling, Huang, Yun, Yang, Dong, Zhou, Li-Huan, Zhong, Zhuo-Yan, Li, Jun-Dong, Deng, Rong, Zhu, Xiao-Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2021; Nature Publishing Group
• Subjects: 631/67/322; 631/67/395; Actin; c-Met protein; Cancer Research; Cell Biology; Drug resistance; Dynamin; Hepatocellular carcinoma; Hepatocyte growth factor; Internal Medicine; Lamellipodia; Liver cancer; Medicine; Medicine & Public Health; Membrane proteins; Metastases; Metastasis; Mitochondria; Oncology; Pathology; Phosphorylation; Protein transport; Protein-tyrosine kinase receptors; Pseudopodia; Tumors

Met tyrosine kinase, a receptor for a hepatocyte growth factor (HGF), plays a critical role in tumor growth, metastasis, and drug resistance. Mitochondria are highly dynamic and undergo fission and fusion to maintain a functional mitochondrial network. Dysregulated mitochondrial dynamics are respons...