Mapping molecular subtype specific alterations in breast cancer brain metastases identifies clinically relevant vulnerabilities

• Published in: Nature communications Vol. 13; no. 1; p. 514
• Main Authors: Cosgrove, Nicola, Varešlija, Damir, Keelan, Stephen, Elangovan, Ashuvinee, Atkinson, Jennifer M., Cocchiglia, Sinéad, Bane, Fiona T., Singh, Vikrant, Furney, Simon, Hu, Chunling, Carter, Jodi M., Hart, Steven N., Yadav, Siddhartha, Goetz, Matthew P., Hill, Arnold D. K., Oesterreich, Steffi, Lee, Adrian V., Couch, Fergus J., Young, Leonie S.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 26.01.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13/51; 38/39; 45/23; 49/23; 49/91; 631/114/2114; 631/67/1347; 692/4028/67/322; Adult; Brain; Brain cancer; Brain Neoplasms - genetics; Brain Neoplasms - metabolism; Brain tumors; Breast; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Explants; Female; Gene mapping; Gene Regulatory Networks; Genes, p53 - genetics; Genomic instability; Homologous recombination; Homology; Humanities and Social Sciences; Humans; Metastases; Metastasis; Middle Aged; Mismatch repair; multidisciplinary; Mutation; Neoplasm Metastasis; Neural plasticity; p53 Protein; Patients; Poly(ADP-ribose) polymerase; Poly(ADP-ribose) Polymerase Inhibitors - pharmacology; Science; Science (multidisciplinary); Transcription; Transcriptome; Transcriptomics; Tumors

The molecular events and transcriptional plasticity driving brain metastasis in clinically relevant breast tumor subtypes has not been determined. Here we comprehensively dissect genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unravel distinct transcripti...