Syndecan-2 regulates PAD2 to exert antifibrotic effects on RA-ILD fibroblasts - Tsoyi, Konstantin; Esposito, Anthony J.; Sun, Bo; Bowen, Ryan G.; Xiong, Kevin; Poli, Fernando; Cardenas, Rafael; Chu, Sarah G.; Liang, Xiaoliang; Ryter, Stefan W.; Beeton, Christine; Doyle, Tracy J.; et al. (Scientific reports, 2022)
Keywords: 692/420; 692/699/1670/498; 692/699/1785; AKT protein; Animals; Anti-Citrullinated Protein Antibodies - genetics; Arthritis; Arthritis, Rheumatoid - complications; Arthritis, Rheumatoid - drug therapy; Arthritis, Rheumatoid - genetics; Arthritis, Rheumatoid - pathology; Bleomycin; Bleomycin - toxicity; Citrullination - genetics; Citrulline; Extracellular matrix; Fibroblasts; Fibroblasts - metabolism; Fibrosis; Gene expression; Gene Expression Regulation - genetics; Humanities and Social Sciences; Humans; Inflammation; Kinases; Lung - metabolism; Lung - pathology; Lung diseases; Lung Injury - chemically induced; Lung Injury - complications; Lung Injury - genetics; Lung Injury - pathology; Mice; Mice, Transgenic; Morbidity; multidisciplinary; Phosphatidylinositol 3-Kinases - genetics; Protein-arginine deiminase; Protein-Arginine Deiminase Type 2 - genetics; Proteins; Proteoglycans; Proto-Oncogene Proteins c-akt - genetics; Pulmonary Fibrosis - complications; Pulmonary Fibrosis - drug therapy; Pulmonary Fibrosis - genetics; Pulmonary Fibrosis - pathology; Receptor-Like Protein Tyrosine Phosphatases, Class 3; Rheumatoid arthritis; Science; Science (multidisciplinary); Sp1 protein; Sp1 Transcription Factor - genetics; Syndecan; Syndecan-2 - genetics; Therapeutic targets; Transgenic mice