Deletion of Mfsd2b impairs thrombotic functions of platelets

• Published in: Nature communications Vol. 12; no. 1; pp. 2286 - 14
• Main Authors: Chandrakanthan, Madhuvanthi, Nguyen, Toan Quoc, Hasan, Zafrul, Muralidharan, Sneha, Vu, Thiet Minh, Li, Aaron Wei Liang, Le, Uyen Thanh Nha, Thi Thuy Ha, Hoa, Baik, Sang-Ha, Tan, Sock Hwee, Foo, Juat Chin, Wenk, Markus R., Cazenave-Gassiot, Amaury, Torta, Federico, Ong, Wei Yi, Chan, Mark Yan Yee, Nguyen, Long N.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.04.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 631/45/287/1196; 631/80/2023; 64/60; 692/4019/592/1339; 82/29; 82/58; 82/80; Accumulation; Animals; Biosynthesis; Blood; Blood cells; Blood platelets; Blood Platelets - cytology; Blood Platelets - drug effects; Blood Platelets - metabolism; Cloning; Cytoplasm; Cytoplasm - metabolism; Deletion; Disease Models, Animal; Fibrinolytic Agents - pharmacology; Fibrinolytic Agents - therapeutic use; Humanities and Social Sciences; Humans; Kinases; Life sciences; Lipids; Lymphocytes; Lysophospholipids - metabolism; Male; Medicine; Membrane Proteins - antagonists & inhibitors; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Knockout; Morphology; multidisciplinary; Physiology; Plasma; Platelet Function Tests; Platelets; Proteins; Roles; Science; Science (multidisciplinary); Sphingolipids; Sphingosine - analogs & derivatives; Sphingosine - metabolism; Sphingosine 1-phosphate; Thrombosis; Venous Thrombosis - blood; Venous Thrombosis - diagnosis; Venous Thrombosis - drug therapy; Venous Thrombosis - pathology

We recently discovered that Mfsd2b, which is the S1P exporter found in blood cells. Here, we report that Mfsd2b is critical for the release of all S1P species in both resting and activated platelets. We show that resting platelets store S1P in the cytoplasm. After activation, this S1P pool is delive...