Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson’s disease

• Published in: Scientific reports Vol. 11; no. 1; pp. 13614 - 14
• Main Authors: Xie, Jing, Chen, Shuting, Bopassa, Jean C., Banerjee, Swati
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.06.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 631/378; 631/80; Aggregates; Animals; Disease Models, Animal; Dopamine receptors; Dopaminergic Neurons - metabolism; Dopaminergic Neurons - pathology; Drosophila; Drosophila melanogaster; Drosophila Proteins - genetics; Drosophila Proteins - metabolism; Genetics; Humanities and Social Sciences; Humans; Insects; Life span; Locomotion; Mitochondria; Movement disorders; multidisciplinary; Mutants; Mutation; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neurodegeneration; Neurodegenerative diseases; Neurotoxicity; Parkinson Disease - genetics; Parkinson Disease - metabolism; Parkinson Disease - pathology; Parkinson's disease; Phenotypes; Polymerization; Science; Science (multidisciplinary); Synuclein; Tubulin

Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Po...