Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson’s disease

Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Po...

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Published inScientific reports Vol. 11; no. 1; pp. 13614 - 14
Main Authors Xie, Jing, Chen, Shuting, Bopassa, Jean C., Banerjee, Swati
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 30.06.2021
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Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Polymerization Promoting Proteins (TPPP) is also implicated in PD and related disorders, where TPPP exists in pathological aggregates in neurons in patient brains. However, there are no in vivo studies on mammalian TPPP to understand the genetics and neuropathology linking TPPP aggregation or neurotoxicity to PD. Recently, we discovered the only Drosophila homolog of human TPPP named Ringmaker (Ringer). Here, we report that adult ringer mutants display progressive locomotor disabilities, reduced lifespan and neurodegeneration. Importantly, our findings reveal that Ringer is associated with mitochondria and ringer mutants have mitochondrial structural damage and dysfunctions. Adult ringer mutants also display progressive loss of dopaminergic neurons. Together, these phenotypes of ringer mutants recapitulate some of the salient features of human PD patients, thus allowing us to utilize ringer mutants as a fly model relevant to PD, and further explore its genetic and molecular underpinnings to gain insights into the role of human TPPP in PD.
AbstractList Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Polymerization Promoting Proteins (TPPP) is also implicated in PD and related disorders, where TPPP exists in pathological aggregates in neurons in patient brains. However, there are no in vivo studies on mammalian TPPP to understand the genetics and neuropathology linking TPPP aggregation or neurotoxicity to PD. Recently, we discovered the only Drosophila homolog of human TPPP named Ringmaker (Ringer). Here, we report that adult ringer mutants display progressive locomotor disabilities, reduced lifespan and neurodegeneration. Importantly, our findings reveal that Ringer is associated with mitochondria and ringer mutants have mitochondrial structural damage and dysfunctions. Adult ringer mutants also display progressive loss of dopaminergic neurons. Together, these phenotypes of ringer mutants recapitulate some of the salient features of human PD patients, thus allowing us to utilize ringer mutants as a fly model relevant to PD, and further explore its genetic and molecular underpinnings to gain insights into the role of human TPPP in PD.
Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Polymerization Promoting Proteins (TPPP) is also implicated in PD and related disorders, where TPPP exists in pathological aggregates in neurons in patient brains. However, there are no in vivo studies on mammalian TPPP to understand the genetics and neuropathology linking TPPP aggregation or neurotoxicity to PD. Recently, we discovered the only Drosophila homolog of human TPPP named Ringmaker (Ringer). Here, we report that adult ringer mutants display progressive locomotor disabilities, reduced lifespan and neurodegeneration. Importantly, our findings reveal that Ringer is associated with mitochondria and ringer mutants have mitochondrial structural damage and dysfunctions. Adult ringer mutants also display progressive loss of dopaminergic neurons. Together, these phenotypes of ringer mutants recapitulate some of the salient features of human PD patients, thus allowing us to utilize ringer mutants as a fly model relevant to PD, and further explore its genetic and molecular underpinnings to gain insights into the role of human TPPP in PD.
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic neuronal loss, mitochondrial dysfunctions and formation of α-Synuclein aggregates. A well-conserved and less understood family of Tubulin Polymerization Promoting Proteins (TPPP) is also implicated in PD and related disorders, where TPPP exists in pathological aggregates in neurons in patient brains. However, there are no in vivo studies on mammalian TPPP to understand the genetics and neuropathology linking TPPP aggregation or neurotoxicity to PD. Recently, we discovered the only Drosophila homolog of human TPPP named Ringmaker (Ringer). Here, we report that adult ringer mutants display progressive locomotor disabilities, reduced lifespan and neurodegeneration. Importantly, our findings reveal that Ringer is associated with mitochondria and ringer mutants have mitochondrial structural damage and dysfunctions. Adult ringer mutants also display progressive loss of dopaminergic neurons. Together, these phenotypes of ringer mutants recapitulate some of the salient features of human PD patients, thus allowing us to utilize ringer mutants as a fly model relevant to PD, and further explore its genetic and molecular underpinnings to gain insights into the role of human TPPP in PD.
ArticleNumber 13614
Author Xie, Jing
Banerjee, Swati
Bopassa, Jean C.
Chen, Shuting
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Cites_doi 10.1523/JNEUROSCI.5383-05.2006
10.1007/s00401-006-0167-4
10.1002/glia.20909
10.1016/j.exger.2005.02.005
10.1016/S0197-4580(02)00065-9
10.1016/j.mcn.2016.11.004
10.3389/fnins.2019.00094
10.1111/j.1471-4159.2006.04073.x
10.1146/annurev.pathol.3.121806.151529
10.1111/gbb.12353
10.1371/journal.pgen.1008184
10.1016/j.neuron.2017.11.036
10.1002/mds.26082
10.1096/fj.11-193540
10.1101/gad.331330.119
10.1021/bi020140g
10.1016/j.neuron.2019.04.013
10.1074/jbc.M410409200
10.1038/s41467-017-00525-4
10.1038/35081564
10.1016/j.neuron.2012.06.026
10.3233/JPD-179004
10.1042/BST20140257
10.3389/fnins.2010.00205
10.1038/nature05876
10.1016/j.tips.2005.05.002
10.1177/1073858415574600
10.3389/fnsys.2017.00076
10.1126/science.1062382
10.1038/nrn.2016.178
10.1073/pnas.2436331100
10.1016/j.bbabio.2012.12.002
10.1016/S0896-6273(03)00568-3
10.1007/s00401-010-0711-0
10.1523/JNEUROSCI.2993-04.2004
10.1038/nature04779
10.1289/ehp.1002839
10.1016/j.neuron.2020.06.010
10.1016/j.neuron.2016.03.038
10.1016/j.pneurobio.2011.06.005
10.1093/hmg/ddq288
10.1101/cshperspect.a009332
10.1016/j.nbd.2004.06.006
10.3389/fncel.2019.00192
10.1038/ncb2012
10.1038/nrdp.2017.13
10.1038/nprot.2006.336
10.1016/j.neuron.2011.06.031
10.1242/jcs.01550
10.1016/j.celrep.2018.03.068
10.7554/eLife.38111
10.1038/nature04788
10.1242/jcs.187294
10.1016/j.cell.2019.08.025
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References Geisler (CR22) 2010; 12
Ota (CR11) 2014; 2
Bertolin (CR23) 2018; 7
Bleier, Drose (CR41) 2013; 1827
Roussarie (CR37) 2020; 107
Irrcher (CR40) 2010; 19
Tirián (CR7) 2003; 100
Gargano, Martin, Bhandari, Grotewiel (CR18) 2005; 40
LeWitt (CR30) 2015; 30
Poewe (CR2) 2017; 3
Yoon, Hwang, Lee, Chung (CR25) 2019; 15
Surmeier, Obeso, Halliday (CR36) 2017; 18
Goedert (CR4) 2001; 2
Dauer, Przedborski (CR39) 2003; 39
Schulz-Schaeffer (CR49) 2010; 120
Saxena, Caroni (CR38) 2011; 71
Wittmann (CR19) 2001; 293
Clark (CR26) 2006; 441
Xie (CR33) 2018; 23
Michel, Hirsch, Hunot (CR48) 2016; 90
Banerjee, Venkatesan, Bhat (CR52) 2017; 78
Doktór, Damulewicz, Pyza (CR55) 2019; 13
Roy, Short, Stanley, Jubinsky (CR28) 2012; 26
White, Humphrey, Hirth (CR32) 2010; 4
Perier, Vila (CR43) 2012; 2
Ordonez, Lee, Feany (CR24) 2018; 97
Banerjee, Pillai, Paik, Li, Bhat (CR51) 2006; 26
Kovács (CR3) 2004; 17
Chow (CR20) 2007; 448
Coulom, Birman (CR27) 2004; 24
Oláh, Ovádi (CR12) 2014; 42
Fernandez (CR29) 2019; 102
Park (CR54) 2006; 441
Lehotzky (CR9) 2004; 117
Vargas (CR17) 2020; 34
Pesah (CR42) 2017; 16
CR15
Wu, Luo (CR50) 2006; 1
Lindersson (CR5) 2005; 280
Braak, Tredici, Rüb, de Vos, Steur, Braak (CR35) 2003; 24
Niens (CR45) 2017; 11
Skjoerringe, Lundvig, Jensen, Moos (CR13) 2006; 99
Shi, Lin, Saliba, Xie, Neely, Banerjee (CR16) 2019; 13
DuBoff, Götz, Feany (CR53) 2012; 75
Mino, Rogers, Risinger, Rohena, Banerjee, Bhat (CR10) 2016; 129
Hlavanda, Kovács, Oláh, Orosz, Medzihradszky, Ovádi (CR8) 2002; 41
Lehotzky, Lau, Tokési, Muja, Hudson, Ovadi (CR14) 2010; 58
Rana (CR21) 2017; 8
Hornykiewicz (CR31) 2017; 7
Lu, Vogel (CR34) 2009; 4
Franco-Iborra, Vila, Perier (CR1) 2016; 22
Tanner (CR44) 2011; 119
Mercuri, Bernardi (CR46) 2005; 26
Lipski, Nistico, Berretta, Guatteo, Bernardi, Mercuri (CR47) 2011; 94
Kovács (CR6) 2007; 113
W Yoon (92738_CR25) 2019; 15
S Banerjee (92738_CR52) 2017; 78
A Fernandez (92738_CR29) 2019; 102
J Park (92738_CR54) 2006; 441
JP Roussarie (92738_CR37) 2020; 107
G Bertolin (92738_CR23) 2018; 7
O Hornykiewicz (92738_CR31) 2017; 7
KE White (92738_CR32) 2010; 4
92738_CR15
GG Kovács (92738_CR3) 2004; 17
DG Ordonez (92738_CR24) 2018; 97
IE Clark (92738_CR26) 2006; 441
H Coulom (92738_CR27) 2004; 24
S Saxena (92738_CR38) 2011; 71
L Tirián (92738_CR7) 2003; 100
T Xie (92738_CR33) 2018; 23
A Lehotzky (92738_CR9) 2004; 117
EJM Vargas (92738_CR17) 2020; 34
S Franco-Iborra (92738_CR1) 2016; 22
A Lehotzky (92738_CR14) 2010; 58
W Dauer (92738_CR39) 2003; 39
J Niens (92738_CR45) 2017; 11
E Hlavanda (92738_CR8) 2002; 41
L Bleier (92738_CR41) 2013; 1827
S Banerjee (92738_CR51) 2006; 26
M Goedert (92738_CR4) 2001; 2
GG Kovács (92738_CR6) 2007; 113
JW Gargano (92738_CR18) 2005; 40
WJ Schulz-Schaeffer (92738_CR49) 2010; 120
RE Mino (92738_CR10) 2016; 129
H Braak (92738_CR35) 2003; 24
J Lipski (92738_CR47) 2011; 94
B Doktór (92738_CR55) 2019; 13
B Lu (92738_CR34) 2009; 4
DJ Surmeier (92738_CR36) 2017; 18
E Lindersson (92738_CR5) 2005; 280
T Skjoerringe (92738_CR13) 2006; 99
C Perier (92738_CR43) 2012; 2
NB Mercuri (92738_CR46) 2005; 26
J Oláh (92738_CR12) 2014; 42
Q Shi (92738_CR16) 2019; 13
S Geisler (92738_CR22) 2010; 12
CM Tanner (92738_CR44) 2011; 119
W Poewe (92738_CR2) 2017; 3
CW Wittmann (92738_CR19) 2001; 293
K Ota (92738_CR11) 2014; 2
A Rana (92738_CR21) 2017; 8
PP Michel (92738_CR48) 2016; 90
B DuBoff (92738_CR53) 2012; 75
JS Wu (92738_CR50) 2006; 1
YC Chow (92738_CR20) 2007; 448
S Roy (92738_CR28) 2012; 26
PA LeWitt (92738_CR30) 2015; 30
Pesah (92738_CR42) 2017; 16
I Irrcher (92738_CR40) 2010; 19
References_xml – volume: 26
  start-page: 3319
  issue: 12
  year: 2006
  end-page: 3329
  ident: CR51
  article-title: Axonal ensheathment and septate junction formation in the peripheral nervous system of Drosophila
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.5383-05.2006
  contributor:
    fullname: Bhat
– volume: 113
  start-page: 153
  year: 2007
  end-page: 161
  ident: CR6
  article-title: The brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-006-0167-4
  contributor:
    fullname: Kovács
– volume: 58
  start-page: 157
  year: 2010
  end-page: 168
  ident: CR14
  article-title: Tubulin polymerization-promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
  publication-title: Glia
  doi: 10.1002/glia.20909
  contributor:
    fullname: Ovadi
– volume: 40
  start-page: 386
  year: 2005
  end-page: 395
  ident: CR18
  article-title: Rapid iterative negative geotaxis (RING): A new method for assessing age-related locomotor decline in Drosophila
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2005.02.005
  contributor:
    fullname: Grotewiel
– volume: 24
  start-page: 197
  year: 2003
  end-page: 211
  ident: CR35
  article-title: Staging of brain pathology related to sporadic Parkinson’s disease
  publication-title: Neurobiol. Aging
  doi: 10.1016/S0197-4580(02)00065-9
  contributor:
    fullname: Braak
– volume: 78
  start-page: 9
  year: 2017
  end-page: 24
  ident: CR52
  article-title: Neurexin, Neuroligin and Wishful Thinking coordinate synaptic cytoarchitecture and growth at neuromuscular junctions
  publication-title: Mol Cell Neurosci.
  doi: 10.1016/j.mcn.2016.11.004
  contributor:
    fullname: Bhat
– volume: 13
  start-page: 94
  year: 2019
  ident: CR55
  article-title: Overexpression of mitochondrial ligases reverses rotenone-induced effects in a Drosophila model of Parkinson's disease
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.00094
  contributor:
    fullname: Pyza
– volume: 99
  start-page: 333
  year: 2006
  end-page: 342
  ident: CR13
  article-title: P25alpha/Tubulin polymerization promoting protein expression by myelinating oligodendrocytes of the developing rat brain
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2006.04073.x
  contributor:
    fullname: Moos
– volume: 4
  start-page: 315
  year: 2009
  end-page: 342
  ident: CR34
  article-title: Drosophila models of neurodegenerative diseases
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev.pathol.3.121806.151529
  contributor:
    fullname: Vogel
– volume: 16
  start-page: 394
  year: 2017
  end-page: 403
  ident: CR42
  article-title: A new brain dopamine-deficient Drosophila and its pharmacological and genetic rescue
  publication-title: Genes Brain Behav.
  doi: 10.1111/gbb.12353
  contributor:
    fullname: Pesah
– volume: 15
  start-page: 1008184
  year: 2019
  ident: CR25
  article-title: Drosophila ADCK1 is critical for maintaining mitochondrial structures and functions in the muscle
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1008184
  contributor:
    fullname: Chung
– volume: 97
  start-page: 108
  year: 2018
  end-page: 124
  ident: CR24
  article-title: a-synuclein Induces mitochondrial dysfunction through spectrin and the actin cytoskeleton
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.11.036
  contributor:
    fullname: Feany
– volume: 30
  start-page: 64
  year: 2015
  end-page: 72
  ident: CR30
  article-title: Levodopa therapy for Parkinson's disease: Pharmacokinetics and pharmacodynamics
  publication-title: Mov. Disord.
  doi: 10.1002/mds.26082
  contributor:
    fullname: LeWitt
– volume: 26
  start-page: 3822
  year: 2012
  end-page: 3833
  ident: CR28
  article-title: Essential role of Drosophila black-pearl is mediated by its effects on mitochondrial respiration
  publication-title: FASEB J.
  doi: 10.1096/fj.11-193540
  contributor:
    fullname: Jubinsky
– volume: 34
  start-page: 1
  year: 2020
  end-page: 15
  ident: CR17
  article-title: The microtubule regulator functions downstream from the RNA repair/splicing pathway to promote axon regeneration
  publication-title: Genes Dev.
  doi: 10.1101/gad.331330.119
  contributor:
    fullname: Vargas
– volume: 41
  start-page: 8657
  year: 2002
  end-page: 8664
  ident: CR8
  article-title: Brain-specific p25 protein binds to tubulin and microtubules and induces aberrant microtubule assemblies at substoichiometric concentrations
  publication-title: Biochemistry
  doi: 10.1021/bi020140g
  contributor:
    fullname: Ovádi
– ident: CR15
– volume: 102
  start-page: 1127
  year: 2019
  end-page: 1142.e3
  ident: CR29
  article-title: Mitochondrial dysfunction leads to cortical under-connectivity and cognitive impairment
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.04.013
  contributor:
    fullname: Fernandez
– volume: 280
  start-page: 5703
  year: 2005
  end-page: 5715
  ident: CR5
  article-title: p25alpha stimulates alpha-synuclein aggregation and is co-localized with aggregated alpha-synuclein in alpha-synucleinopathies
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M410409200
  contributor:
    fullname: Lindersson
– volume: 8
  start-page: 448
  year: 2017
  ident: CR21
  article-title: Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00525-4
  contributor:
    fullname: Rana
– volume: 2
  start-page: 492
  year: 2001
  end-page: 501
  ident: CR4
  article-title: Alpha-synuclein and neurodegenerative diseases
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/35081564
  contributor:
    fullname: Goedert
– volume: 2
  start-page: 136
  year: 2014
  ident: CR11
  article-title: Relocation of p25α/tubulin polymerization promoting protein from the nucleus to the perinuclear cytoplasm in the oligodendroglia of sporadic and COQ2 mutant multiple system atrophy
  publication-title: Acta Neuropathol. Commun.
  contributor:
    fullname: Ota
– volume: 75
  start-page: 618
  year: 2012
  end-page: 632
  ident: CR53
  article-title: Tau promotes neurodegeneration via DRP1 mislocalization in vivo
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.06.026
  contributor:
    fullname: Feany
– volume: 7
  start-page: S3
  year: 2017
  end-page: S10
  ident: CR31
  article-title: L-DOPA
  publication-title: J. Parkinsons Dis.
  doi: 10.3233/JPD-179004
  contributor:
    fullname: Hornykiewicz
– volume: 42
  start-page: 1762
  year: 2014
  end-page: 1767
  ident: CR12
  article-title: Dual life of TPPP/p25 evolved in physiological and pathological conditions
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST20140257
  contributor:
    fullname: Ovádi
– volume: 4
  start-page: 205
  year: 2010
  ident: CR32
  article-title: The dopaminergic system in the aging brain of Drosophila
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2010.00205
  contributor:
    fullname: Hirth
– volume: 448
  start-page: 68
  issue: 7149
  year: 2007
  end-page: 72
  ident: CR20
  article-title: Mutation of FIG4 causes neurodegeneration in the pale tremor mouse and patients with CMT4J
  publication-title: Nature
  doi: 10.1038/nature05876
  contributor:
    fullname: Chow
– volume: 26
  start-page: 341
  issue: 7
  year: 2005
  end-page: 344
  ident: CR46
  article-title: The 'magic' of L-dopa: Why is it the gold standard Parkinson's disease therapy?
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2005.05.002
  contributor:
    fullname: Bernardi
– volume: 22
  start-page: 266
  year: 2016
  end-page: 277
  ident: CR1
  article-title: The Parkinson disease mitochondrial hypothesis: Where are we at?
  publication-title: Neuroscientist
  doi: 10.1177/1073858415574600
  contributor:
    fullname: Perier
– volume: 11
  start-page: 76
  year: 2017
  ident: CR45
  article-title: Dopamine modulates serotonin innervation in the Drosophila brain
  publication-title: Front. Syst. Neurosci.
  doi: 10.3389/fnsys.2017.00076
  contributor:
    fullname: Niens
– volume: 293
  start-page: 711
  year: 2001
  end-page: 714
  ident: CR19
  article-title: Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
  publication-title: Science
  doi: 10.1126/science.1062382
  contributor:
    fullname: Wittmann
– volume: 18
  start-page: 101
  year: 2017
  end-page: 113
  ident: CR36
  article-title: Selective neuronal vulnerability in Parkinson disease
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.178
  contributor:
    fullname: Halliday
– volume: 100
  start-page: 13976
  year: 2003
  end-page: 13981
  ident: CR7
  article-title: TPPP/p25 promotes tubulin assemblies and blocks mitotic spindle formation
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.2436331100
  contributor:
    fullname: Tirián
– volume: 1827
  start-page: 1320
  issue: 11–12
  year: 2013
  end-page: 1331
  ident: CR41
  article-title: Superoxide generation by complex III: From mechanistic rationales to functional consequences
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2012.12.002
  contributor:
    fullname: Drose
– volume: 39
  start-page: 889
  year: 2003
  end-page: 909
  ident: CR39
  article-title: Parkinson's disease: Mechanisms and models
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00568-3
  contributor:
    fullname: Przedborski
– volume: 120
  start-page: 131
  year: 2010
  end-page: 143
  ident: CR49
  article-title: The synaptic pathology of alpha-synuclein aggregation in dementia with Lewy bodies, Parkinson's disease and Parkinson's disease dementia
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-010-0711-0
  contributor:
    fullname: Schulz-Schaeffer
– volume: 24
  start-page: 10993
  year: 2004
  end-page: 10998
  ident: CR27
  article-title: Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2993-04.2004
  contributor:
    fullname: Birman
– volume: 441
  start-page: 1162
  year: 2006
  end-page: 1166
  ident: CR26
  article-title: Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
  publication-title: Nature
  doi: 10.1038/nature04779
  contributor:
    fullname: Clark
– volume: 119
  start-page: 866
  year: 2011
  end-page: 872
  ident: CR44
  article-title: Rotenone, paraquat, and Parkinson's disease
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.1002839
  contributor:
    fullname: Tanner
– volume: 107
  start-page: 821
  year: 2020
  end-page: 835
  ident: CR37
  article-title: Selective neuronal vulnerability in Alzheimer’s disease: A network-based analysis
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.06.010
  contributor:
    fullname: Roussarie
– volume: 90
  start-page: 675
  year: 2016
  end-page: 691
  ident: CR48
  article-title: Understanding dopaminergic cell death pathways in Parkinson disease
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.03.038
  contributor:
    fullname: Hunot
– volume: 94
  start-page: 389
  issue: 4
  year: 2011
  end-page: 407
  ident: CR47
  article-title: L-DOPA: A scapegoat for accelerated neurodegeneration in Parkinson's disease?
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2011.06.005
  contributor:
    fullname: Mercuri
– volume: 19
  start-page: 3734
  year: 2010
  end-page: 3746
  ident: CR40
  article-title: Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddq288
  contributor:
    fullname: Irrcher
– volume: 2
  start-page: a009332
  issue: 2
  year: 2012
  ident: CR43
  article-title: Mitochondrial biology and Parkinson's disease
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a009332
  contributor:
    fullname: Vila
– volume: 129
  start-page: 3282
  year: 2016
  end-page: 3294
  ident: CR10
  article-title: Drosophila Ringmaker regulates microtubule stabilization and axonal extension during embryonic development
  publication-title: J. Cell Sci.
  contributor:
    fullname: Bhat
– volume: 17
  start-page: 155
  year: 2004
  end-page: 162
  ident: CR3
  article-title: Natively unfolded tubulin polymerization promoting protein TPPP/p25 is a common marker of alpha-synucleinopathies
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2004.06.006
  contributor:
    fullname: Kovács
– volume: 13
  start-page: 192
  year: 2019
  ident: CR16
  article-title: Tubulin polymerization promoting protein, ringmaker, and MAP1B homolog futsch coordinate microtubule organization and synaptic growth
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2019.00192
  contributor:
    fullname: Banerjee
– volume: 12
  start-page: 119
  year: 2010
  end-page: 131
  ident: CR22
  article-title: PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2012
  contributor:
    fullname: Geisler
– volume: 3
  start-page: 17013
  year: 2017
  ident: CR2
  article-title: Parkinson disease
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/nrdp.2017.13
  contributor:
    fullname: Poewe
– volume: 1
  start-page: 2110
  year: 2006
  end-page: 2115
  ident: CR50
  article-title: A protocol for dissecting brains for live imaging or immunostaining
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.336
  contributor:
    fullname: Luo
– volume: 71
  start-page: 35
  year: 2011
  end-page: 48
  ident: CR38
  article-title: Selective neuronal vulnerability in neurodegenerative diseases: From stressor thresholds to degeneration
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.06.031
  contributor:
    fullname: Caroni
– volume: 117
  start-page: 6249
  year: 2004
  end-page: 6259
  ident: CR9
  article-title: Dynamic targeting of microtubules by TPPP/p25 affects cell survival
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.01550
  contributor:
    fullname: Lehotzky
– volume: 23
  start-page: 652
  year: 2018
  end-page: 665
  ident: CR33
  article-title: A genetic toolkit for dissecting dopamine circuit function in Drosophila
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.068
  contributor:
    fullname: Xie
– volume: 7
  start-page: e38111
  year: 2018
  ident: CR23
  article-title: Aurora kinase A localises to mitochondria to control organelle dynamics and energy production
  publication-title: Elife
  doi: 10.7554/eLife.38111
  contributor:
    fullname: Bertolin
– volume: 441
  start-page: 1157
  year: 2006
  end-page: 1161
  ident: CR54
  article-title: Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
  publication-title: Nature
  doi: 10.1038/nature04788
  contributor:
    fullname: Park
– volume: 8
  start-page: 448
  year: 2017
  ident: 92738_CR21
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-00525-4
  contributor:
    fullname: A Rana
– volume: 99
  start-page: 333
  year: 2006
  ident: 92738_CR13
  publication-title: J. Neurochem.
  doi: 10.1111/j.1471-4159.2006.04073.x
  contributor:
    fullname: T Skjoerringe
– volume: 7
  start-page: S3
  year: 2017
  ident: 92738_CR31
  publication-title: J. Parkinsons Dis.
  doi: 10.3233/JPD-179004
  contributor:
    fullname: O Hornykiewicz
– volume: 40
  start-page: 386
  year: 2005
  ident: 92738_CR18
  publication-title: Exp. Gerontol.
  doi: 10.1016/j.exger.2005.02.005
  contributor:
    fullname: JW Gargano
– volume: 71
  start-page: 35
  year: 2011
  ident: 92738_CR38
  publication-title: Neuron
  doi: 10.1016/j.neuron.2011.06.031
  contributor:
    fullname: S Saxena
– volume: 13
  start-page: 94
  year: 2019
  ident: 92738_CR55
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2019.00094
  contributor:
    fullname: B Doktór
– volume: 280
  start-page: 5703
  year: 2005
  ident: 92738_CR5
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M410409200
  contributor:
    fullname: E Lindersson
– volume: 94
  start-page: 389
  issue: 4
  year: 2011
  ident: 92738_CR47
  publication-title: Prog. Neurobiol.
  doi: 10.1016/j.pneurobio.2011.06.005
  contributor:
    fullname: J Lipski
– volume: 2
  start-page: a009332
  issue: 2
  year: 2012
  ident: 92738_CR43
  publication-title: Cold Spring Harb. Perspect. Med.
  doi: 10.1101/cshperspect.a009332
  contributor:
    fullname: C Perier
– volume: 1
  start-page: 2110
  year: 2006
  ident: 92738_CR50
  publication-title: Nat. Protoc.
  doi: 10.1038/nprot.2006.336
  contributor:
    fullname: JS Wu
– volume: 441
  start-page: 1162
  year: 2006
  ident: 92738_CR26
  publication-title: Nature
  doi: 10.1038/nature04779
  contributor:
    fullname: IE Clark
– volume: 16
  start-page: 394
  year: 2017
  ident: 92738_CR42
  publication-title: Genes Brain Behav.
  doi: 10.1111/gbb.12353
  contributor:
    fullname: Pesah
– volume: 12
  start-page: 119
  year: 2010
  ident: 92738_CR22
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2012
  contributor:
    fullname: S Geisler
– volume: 19
  start-page: 3734
  year: 2010
  ident: 92738_CR40
  publication-title: Hum. Mol. Genet.
  doi: 10.1093/hmg/ddq288
  contributor:
    fullname: I Irrcher
– volume: 1827
  start-page: 1320
  issue: 11–12
  year: 2013
  ident: 92738_CR41
  publication-title: Biochim. Biophys. Acta
  doi: 10.1016/j.bbabio.2012.12.002
  contributor:
    fullname: L Bleier
– volume: 102
  start-page: 1127
  year: 2019
  ident: 92738_CR29
  publication-title: Neuron
  doi: 10.1016/j.neuron.2019.04.013
  contributor:
    fullname: A Fernandez
– volume: 4
  start-page: 205
  year: 2010
  ident: 92738_CR32
  publication-title: Front. Neurosci.
  doi: 10.3389/fnins.2010.00205
  contributor:
    fullname: KE White
– volume: 100
  start-page: 13976
  year: 2003
  ident: 92738_CR7
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.2436331100
  contributor:
    fullname: L Tirián
– volume: 39
  start-page: 889
  year: 2003
  ident: 92738_CR39
  publication-title: Neuron
  doi: 10.1016/S0896-6273(03)00568-3
  contributor:
    fullname: W Dauer
– volume: 129
  start-page: 3282
  year: 2016
  ident: 92738_CR10
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.187294
  contributor:
    fullname: RE Mino
– volume: 2
  start-page: 136
  year: 2014
  ident: 92738_CR11
  publication-title: Acta Neuropathol. Commun.
  contributor:
    fullname: K Ota
– volume: 107
  start-page: 821
  year: 2020
  ident: 92738_CR37
  publication-title: Neuron
  doi: 10.1016/j.neuron.2020.06.010
  contributor:
    fullname: JP Roussarie
– ident: 92738_CR15
  doi: 10.1016/j.cell.2019.08.025
– volume: 23
  start-page: 652
  year: 2018
  ident: 92738_CR33
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2018.03.068
  contributor:
    fullname: T Xie
– volume: 78
  start-page: 9
  year: 2017
  ident: 92738_CR52
  publication-title: Mol Cell Neurosci.
  doi: 10.1016/j.mcn.2016.11.004
  contributor:
    fullname: S Banerjee
– volume: 26
  start-page: 341
  issue: 7
  year: 2005
  ident: 92738_CR46
  publication-title: Trends Pharmacol. Sci.
  doi: 10.1016/j.tips.2005.05.002
  contributor:
    fullname: NB Mercuri
– volume: 58
  start-page: 157
  year: 2010
  ident: 92738_CR14
  publication-title: Glia
  doi: 10.1002/glia.20909
  contributor:
    fullname: A Lehotzky
– volume: 293
  start-page: 711
  year: 2001
  ident: 92738_CR19
  publication-title: Science
  doi: 10.1126/science.1062382
  contributor:
    fullname: CW Wittmann
– volume: 26
  start-page: 3319
  issue: 12
  year: 2006
  ident: 92738_CR51
  publication-title: J Neurosci.
  doi: 10.1523/JNEUROSCI.5383-05.2006
  contributor:
    fullname: S Banerjee
– volume: 26
  start-page: 3822
  year: 2012
  ident: 92738_CR28
  publication-title: FASEB J.
  doi: 10.1096/fj.11-193540
  contributor:
    fullname: S Roy
– volume: 90
  start-page: 675
  year: 2016
  ident: 92738_CR48
  publication-title: Neuron
  doi: 10.1016/j.neuron.2016.03.038
  contributor:
    fullname: PP Michel
– volume: 2
  start-page: 492
  year: 2001
  ident: 92738_CR4
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/35081564
  contributor:
    fullname: M Goedert
– volume: 34
  start-page: 1
  year: 2020
  ident: 92738_CR17
  publication-title: Genes Dev.
  doi: 10.1101/gad.331330.119
  contributor:
    fullname: EJM Vargas
– volume: 41
  start-page: 8657
  year: 2002
  ident: 92738_CR8
  publication-title: Biochemistry
  doi: 10.1021/bi020140g
  contributor:
    fullname: E Hlavanda
– volume: 30
  start-page: 64
  year: 2015
  ident: 92738_CR30
  publication-title: Mov. Disord.
  doi: 10.1002/mds.26082
  contributor:
    fullname: PA LeWitt
– volume: 120
  start-page: 131
  year: 2010
  ident: 92738_CR49
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-010-0711-0
  contributor:
    fullname: WJ Schulz-Schaeffer
– volume: 441
  start-page: 1157
  year: 2006
  ident: 92738_CR54
  publication-title: Nature
  doi: 10.1038/nature04788
  contributor:
    fullname: J Park
– volume: 448
  start-page: 68
  issue: 7149
  year: 2007
  ident: 92738_CR20
  publication-title: Nature
  doi: 10.1038/nature05876
  contributor:
    fullname: YC Chow
– volume: 75
  start-page: 618
  year: 2012
  ident: 92738_CR53
  publication-title: Neuron
  doi: 10.1016/j.neuron.2012.06.026
  contributor:
    fullname: B DuBoff
– volume: 18
  start-page: 101
  year: 2017
  ident: 92738_CR36
  publication-title: Nat. Rev. Neurosci.
  doi: 10.1038/nrn.2016.178
  contributor:
    fullname: DJ Surmeier
– volume: 11
  start-page: 76
  year: 2017
  ident: 92738_CR45
  publication-title: Front. Syst. Neurosci.
  doi: 10.3389/fnsys.2017.00076
  contributor:
    fullname: J Niens
– volume: 24
  start-page: 197
  year: 2003
  ident: 92738_CR35
  publication-title: Neurobiol. Aging
  doi: 10.1016/S0197-4580(02)00065-9
  contributor:
    fullname: H Braak
– volume: 3
  start-page: 17013
  year: 2017
  ident: 92738_CR2
  publication-title: Nat. Rev. Dis. Prim.
  doi: 10.1038/nrdp.2017.13
  contributor:
    fullname: W Poewe
– volume: 24
  start-page: 10993
  year: 2004
  ident: 92738_CR27
  publication-title: J. Neurosci.
  doi: 10.1523/JNEUROSCI.2993-04.2004
  contributor:
    fullname: H Coulom
– volume: 42
  start-page: 1762
  year: 2014
  ident: 92738_CR12
  publication-title: Biochem. Soc. Trans.
  doi: 10.1042/BST20140257
  contributor:
    fullname: J Oláh
– volume: 15
  start-page: 1008184
  year: 2019
  ident: 92738_CR25
  publication-title: PLoS Genet
  doi: 10.1371/journal.pgen.1008184
  contributor:
    fullname: W Yoon
– volume: 97
  start-page: 108
  year: 2018
  ident: 92738_CR24
  publication-title: Neuron
  doi: 10.1016/j.neuron.2017.11.036
  contributor:
    fullname: DG Ordonez
– volume: 17
  start-page: 155
  year: 2004
  ident: 92738_CR3
  publication-title: Neurobiol. Dis.
  doi: 10.1016/j.nbd.2004.06.006
  contributor:
    fullname: GG Kovács
– volume: 113
  start-page: 153
  year: 2007
  ident: 92738_CR6
  publication-title: Acta Neuropathol.
  doi: 10.1007/s00401-006-0167-4
  contributor:
    fullname: GG Kovács
– volume: 7
  start-page: e38111
  year: 2018
  ident: 92738_CR23
  publication-title: Elife
  doi: 10.7554/eLife.38111
  contributor:
    fullname: G Bertolin
– volume: 119
  start-page: 866
  year: 2011
  ident: 92738_CR44
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.1002839
  contributor:
    fullname: CM Tanner
– volume: 22
  start-page: 266
  year: 2016
  ident: 92738_CR1
  publication-title: Neuroscientist
  doi: 10.1177/1073858415574600
  contributor:
    fullname: S Franco-Iborra
– volume: 13
  start-page: 192
  year: 2019
  ident: 92738_CR16
  publication-title: Front. Cell. Neurosci.
  doi: 10.3389/fncel.2019.00192
  contributor:
    fullname: Q Shi
– volume: 4
  start-page: 315
  year: 2009
  ident: 92738_CR34
  publication-title: Annu. Rev. Pathol.
  doi: 10.1146/annurev.pathol.3.121806.151529
  contributor:
    fullname: B Lu
– volume: 117
  start-page: 6249
  year: 2004
  ident: 92738_CR9
  publication-title: J. Cell Sci.
  doi: 10.1242/jcs.01550
  contributor:
    fullname: A Lehotzky
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Snippet Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic...
Parkinson's disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal dopaminergic...
Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder with no known cure. PD is characterized by locomotion deficits, nigrostriatal...
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SubjectTerms 631/378
631/80
Aggregates
Animals
Disease Models, Animal
Dopamine receptors
Dopaminergic Neurons - metabolism
Dopaminergic Neurons - pathology
Drosophila
Drosophila melanogaster
Drosophila Proteins - genetics
Drosophila Proteins - metabolism
Genetics
Humanities and Social Sciences
Humans
Insects
Life span
Locomotion
Mitochondria
Movement disorders
multidisciplinary
Mutants
Mutation
Nerve Tissue Proteins - genetics
Nerve Tissue Proteins - metabolism
Neurodegeneration
Neurodegenerative diseases
Neurotoxicity
Parkinson Disease - genetics
Parkinson Disease - metabolism
Parkinson Disease - pathology
Parkinson's disease
Phenotypes
Polymerization
Science
Science (multidisciplinary)
Synuclein
Tubulin
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Title Drosophila tubulin polymerization promoting protein mutants reveal pathological correlates relevant to human Parkinson’s disease
URI https://link.springer.com/article/10.1038/s41598-021-92738-3
https://www.ncbi.nlm.nih.gov/pubmed/34193896
https://www.proquest.com/docview/2546782850
https://pubmed.ncbi.nlm.nih.gov/PMC8245532
https://doaj.org/article/28fc479e7f7f4186972589d55fc1408f
Volume 11
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