Mechanical load regulates bone growth via periosteal Osteocrin

• Published in: Cell reports (Cambridge) Vol. 36; no. 2; p. 109380
• Main Authors: Watanabe-Takano, Haruko, Ochi, Hiroki, Chiba, Ayano, Matsuo, Ayaka, Kanai, Yugo, Fukuhara, Shigetomo, Ito, Naoki, Sako, Keisuke, Miyazaki, Takahiro, Tainaka, Kazuki, Harada, Ichiro, Sato, Shingo, Sawada, Yasuhiro, Minamino, Naoto, Takeda, Shu, Ueda, Hiroki R., Yasoda, Akihiro, Mochizuki, Naoki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 13.07.2021; Elsevier
• Subjects: Animals; Bone Development; Bone growth; Cell Differentiation; Chondrocyte; CNP; Mechanical load; Mice; Mice, Knockout; Muscle Proteins - metabolism; Natriuretic Peptide, C-Type - metabolism; Osteoblast; Osteoblasts - metabolism; Osteocrin; Osteogenesis; Periosteum; Periosteum - growth & development; Periosteum - metabolism; Receptors, Atrial Natriuretic Factor - metabolism; Signal Transduction; Stress, Mechanical; Transcription Factors - metabolism; Weight-Bearing; Osteocrin; Bone growth; CNP; Chondrocyte; Periosteum; Osteoblast; Mechanical load

Mechanical stimuli including loading after birth promote bone growth. However, little is known about how mechanical force triggers biochemical signals to regulate bone growth. Here, we identified a periosteal-osteoblast-derived secretory peptide, Osteocrin (OSTN), as a mechanotransducer involved in...