Activation of peripheral TRPM8 mitigates ischemic stroke by topically applied menthol

• Published in: Journal of neuroinflammation Vol. 19; no. 1; pp. 1 - 18
• Main Authors: Huang, Shiang-Suo, Su, Hsing-Hui, Chien, Szu-Yu, Chung, Hsin-Yi, Luo, Sih-Ting, Chu, Yu-Ting, Wang, Yi-Hsin, MacDonald, Iona J., Lee, Hsun-Hua, Chen, Yi-Hung
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 27.07.2022; BioMed Central; BMC
• Subjects: Acute ischemic stroke; Analgesics; Brain research; Care and treatment; Cerebral blood flow; Cold; Diagnosis; Ethanol; Experiments; FDA approval; Health aspects; Immunohistochemistry; Inflammation; Ischemia; Laboratory animals; Lidocaine; Macrophages; Medical research; Menthol; Monocytes; Nerve conduction; Neuroprotection; Oxidative stress; Peripheral nerves; Sensorimotor system; Skin; Stroke; Stroke (Disease); Tissue plasminogen activator; Topical; Topical application; Transient receptor potential proteins; TRPM8; Taiwan; United States > US; Germany

Background No reports exist as to neuroprotective effects associated with topical activation of transient receptor potential melastatin 8 (TRPM8), a noted cold receptor. In the present study, we identified whether activating peripheral TRPM8 can be an adjuvant therapy for ischemic stroke. Methods Me...