FXR expression in rats of hilar cholangiocarcinoma

• Published in: Scientific reports Vol. 12; no. 1; pp. 8741 - 7
• Main Authors: Zhang, Meng-yu, Luo, Ming, Wang, Jie-ping
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 24.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/67; 692/699/67/70; Alanine; Alanine transaminase; Animal models; Animals; Aspartate transaminase; Bile Duct Neoplasms - pathology; Bile ducts; Bile Ducts, Intrahepatic - pathology; Cholangiocarcinoma; Cholangiocarcinoma - pathology; Drug delivery; Drug development; Gene therapy; Glyceraldehyde-3-phosphate dehydrogenase; Humanities and Social Sciences; Immunohistochemistry; Klatskin Tumor - genetics; Klatskin Tumor - pathology; Male; mRNA; multidisciplinary; Physical activity; Polymerase chain reaction; Rats; Rats, Wistar; Rodents; Science; Science (multidisciplinary); Therapeutic targets; Transaminase; Tumors

The study objective was to detect the expression of farnesoid X receptor (FXR) in a rat model of hilar cholangiocarcinoma to provide a new therapeutic target for gene therapy in hilar cholangiocarcinoma. Sixty male Wistar rats (weighing 190 ± 8 g) were randomly divided into three groups (experimenta...