The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation

• Published in: Cell reports (Cambridge) Vol. 27; no. 2; pp. 343 - 358.e5
• Main Authors: Li, Dongfang, Zhao, Yan G., Li, Di, Zhao, Hongyu, Huang, Jie, Miao, Guangyan, Feng, Du, Liu, Pingsheng, Li, Dong, Zhang, Hong
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.04.2019; Elsevier
• Subjects: BSCL2; DFCP1; lipid droplets; membrane contact; Rab18; BSCL2; membrane contact; Rab18; lipid droplets; DFCP1

Very little is known about the spatiotemporal generation of lipid droplets (LDs) from the endoplasmic reticulum (ER) and the factors that mediate ER-LD contacts for LD growth. Using super-resolution grazing incidence structured illumination microscopy (GI-SIM) live-cell imaging, we reveal that upon...