Sequential Sensing by TLR2 and Mincle Directs Immature Myeloid Cells to Protect against Invasive Group A Streptococcal Infection in Mice

• Published in: Cell reports (Cambridge) Vol. 27; no. 2; pp. 561 - 571.e6
• Main Authors: Matsumura, Takayuki, Ikebe, Tadayoshi, Arikawa, Koji, Hosokawa, Masahito, Aiko, Michio, Iguchi, Aoi, Togashi, Ikuko, Kai, Sayaka, Ohara, Sakiko, Ohara, Naoya, Ohnishi, Makoto, Watanabe, Haruo, Kobayashi, Kazuo, Takeyama, Haruko, Yamasaki, Sho, Takahashi, Yoshimasa, Ato, Manabu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 09.04.2019; Elsevier
• Subjects: C-type lectin receptors; cytokines; group A Streptococcus infections; immature myeloid cells; Toll-like receptors; Toll-like receptors; C-type lectin receptors; cytokines; immature myeloid cells; group A Streptococcus infections

Severe invasive group A Streptococcus (GAS) infection evades anti-bacterial immunity by attenuating the cellular components of innate immune responses. However, this loss of protection is compensated for by interferon (IFN)-γ-producing immature myeloid cells (γIMCs), which are selectively recruited...