Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model

Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an...

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Published inScientific reports Vol. 10; no. 1; p. 4697
Main Authors Saunders, Justin M., Moreno, José L., Ibi, Daisuke, Sikaroodi, Masoumeh, Kang, Dae Joong, Muñoz-Moreno, Raquel, Dalmet, Swati S., García-Sastre, Adolfo, Gillevet, Patrick M., Dozmorov, Mikhail G., Bajaj, Jasmohan S., González-Maeso, Javier
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 13.03.2020
Nature Publishing Group
Subjects
631/136/1425
631/326/2565/2134
631/378/1689/1799
64/60
Age Factors
Animals
Anti-Bacterial Agents - administration & dosage
Antibiotics
Autism
Behavior
Behavior, Animal
Brain injury
Cognitive ability
Cortex (frontal)
Disease Models, Animal
Disease Susceptibility
Gastrointestinal Microbiome
Gut microbiota
Gut-brain axis
Humanities and Social Sciences
Immune response
Immune system
Influenza
Intestinal microflora
Memory
Mental disorders
Mice
Microbiota
multidisciplinary
Neurodevelopmental disorders
Neurodevelopmental Disorders - etiology
Neurodevelopmental Disorders - psychology
Offspring
Pattern recognition
Phenotype
Phenotypes
Pregnancy
Problem Behavior
Receptor density
Recognition, Psychology
Relative abundance
Schizophrenia
Schizophrenia - etiology
Science
Science (multidisciplinary)
Serotonin S2 receptors
Sexual Maturation
Transplantation
Online AccessGet full text
ISSN2045-2322
2045-2322
DOI10.1038/s41598-020-61635-6

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Abstract Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT 2A receptor (5-HT 2A R) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT 2A R agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT 2A R density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae , correlated with frontal cortex 5-HT 2A R density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.
AbstractList Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT2A receptor (5-HT2AR) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT2AR agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT2AR density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae, correlated with frontal cortex 5-HT2AR density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT2A receptor (5-HT2AR) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT2AR agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT2AR density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae, correlated with frontal cortex 5-HT2AR density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.
Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT receptor (5-HT R) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT R agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT R density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae, correlated with frontal cortex 5-HT R density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.
Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT 2A receptor (5-HT 2A R) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT 2A R agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT 2A R density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae , correlated with frontal cortex 5-HT 2A R density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.
Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and behavior. Here we show that maternal immune activation (MIA) accomplished by infection with a mouse-adapted influenza virus during pregnancy induced up-regulation of frontal cortex serotonin 5-HT2A receptor (5-HT2AR) density in the adult offspring, a phenotype previously observed in postmortem frontal cortex of schizophrenic subjects. 5-HT2AR agonist-induced head-twitch behavior was also augmented in this preclinical mouse model. Using the novel object recognition (NOR) test to evaluate cognitive performance, we demonstrate that MIA induced NOR deficits in adult offspring. Oral antibiotic treatment of prepubertal mice prevented this cognitive impairment, but not increased frontal cortex 5-HT2AR density or psychedelic-induced head-twitch behavior in adult MIA offspring. Additionally, gut microbiota transplantation from MIA mice produced behavioral deficits in antibiotic-treated mock mice. Adult MIA offspring displayed altered gut microbiota, and relative abundance of specific components of the gut microbiota, including Ruminococcaceae, correlated with frontal cortex 5-HT2AR density. Together, these findings provide a better understanding of basic mechanisms by which prenatal insults impact offspring brain function, and suggest gut-brain axis manipulation as a potential therapeutic approach for neurodevelopmental psychiatric conditions.
ArticleNumber 4697
Author García-Sastre, Adolfo
González-Maeso, Javier
Kang, Dae Joong
Saunders, Justin M.
Sikaroodi, Masoumeh
Muñoz-Moreno, Raquel
Bajaj, Jasmohan S.
Moreno, José L.
Dalmet, Swati S.
Ibi, Daisuke
Gillevet, Patrick M.
Dozmorov, Mikhail G.
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  orcidid: 0000-0002-6551-1827
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32170216$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1016/S0140-6736(03)14471-6
10.1186/s13041-017-0292-0
10.3390/nu11020337
10.1038/srep44182
10.1371/journal.pone.0026988
10.1038/s41386-018-0185-7
10.1038/nm.4142
10.1016/j.biopsych.2013.06.025
10.1038/nature06612
10.1523/JNEUROSCI.2087-13.2013
10.1186/gb-2011-12-6-r60
10.1016/j.psyneuen.2006.11.005
10.1016/j.cell.2015.02.047
10.1016/j.pneurobio.2013.04.001
10.1176/ajp.2006.163.5.790
10.1016/j.bbi.2015.10.007
10.1016/j.psychres.2014.06.046
10.1038/nrmicro2876
10.1016/j.bbi.2016.02.020
10.1016/j.cell.2016.10.027
10.1176/appi.ajp.2009.09030361
10.3389/fmicb.2018.03146
10.1016/j.cell.2013.12.016
10.1523/JNEUROSCI.2331-12.2013
10.1021/cn300138m
10.1016/j.euroneuro.2012.10.006
10.1038/mp.2016.44
10.1176/appi.ajp.162.4.767
10.1016/S0006-3223(01)01068-X
10.1523/JNEUROSCI.4230-10.2011
10.1016/S0920-9964(02)00167-6
10.1016/j.cell.2016.12.021
10.1007/s13197-015-1921-1
10.1093/schbul/sbu197
10.1038/nmeth.f.303
10.1016/j.neuron.2007.01.008
10.1016/j.neuroscience.2018.07.010
10.7717/peerj.1140
10.1038/srep18559
10.1038/nn.4616
10.1016/j.neuro.2007.01.014
10.1001/archpsyc.61.8.774
10.1128/AEM.00062-07
10.1001/jama.2008.980
10.1038/srep38481
10.1016/j.neuropharm.2014.08.009
10.1093/femsre/fuv036
10.1016/j.bbi.2015.04.004
10.1016/j.cell.2019.05.004
10.1056/NEJMra035458
10.1073/pnas.1323287111
10.1056/NEJMra1600266
10.1016/j.neuroscience.2015.06.008
10.1038/tp.2016.38
10.1371/journal.pone.0137725
10.1371/journal.pone.0076993
10.1124/pr.115.011478
10.1097/00001756-199812010-00024
10.1016/j.neuropharm.2015.05.029
10.1038/nature13595
10.1016/j.bbr.2003.12.001
10.1016/j.cell.2013.11.024
10.1038/nature18848
10.7554/eLife.33746
10.1016/j.neures.2015.07.002
10.3390/ma11071129
10.1038/nature23874
10.1038/nature23910
10.1016/j.pbb.2017.06.016
10.1016/j.biopsych.2014.11.015
10.1016/j.schres.2018.01.002
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References Brown (CR4) 2001; 49
Yolken (CR14) 2015; 41
McGlashan (CR37) 2006; 163
Lim, Lim, Choi, Ko (CR19) 2017; 10
Plaza-Díaz, Gómez-Fernández, Chueca, Torre-Aguilar, Gil, Perez-Navero, Flores-Rojas, Martín-Borreguero, Solis-Urra, Ruiz-Ojeda, Garcia, Gil-Campos (CR44) 2019; 11
de la Fuente Revenga (CR66) 2018; 388
Yudofsky (CR3) 2009; 301
Sharon (CR56) 2019; 177
CR34
Tamburini, Shen, Wu, Clemente (CR12) 2016; 22
Nichols (CR53) 2016; 68
CR30
Hsiao (CR18) 2013; 155
Segata (CR41) 2011; 12
Clancy, Finlay, Darlington, Anand (CR63) 2007; 28
Kentner (CR9) 2019; 44
Muguruza (CR27) 2013; 23
De Vadder (CR59) 2014; 156
De Angelis (CR16) 2013; 8
Collins, Surette, Bercik (CR49) 2012; 10
CR48
Malkova, Gallagher, Yu, Jacobs, Patterson (CR31) 2014; 111
Wang, Garrity, Tiedje, Cole (CR70) 2007; 73
CR45
Ibi (CR65) 2017; 20
Coretti (CR43) 2018; 9
Guo (CR60) 2017; 168
Hanks, Gonzalez-Maeso (CR36) 2013; 4
Honda, Littman (CR46) 2016; 535
Zheng (CR42) 2016; 21
Gonzalez-Maeso (CR26) 2008; 452
Brown (CR6) 2005; 162
Brown, Derkits (CR5) 2010; 167
Yano (CR61) 2015; 161
Castro-Nallar (CR13) 2015; 3
Semple, Blomgren, Gimlin, Ferriero, Noble-Haeusslein (CR67) 2013; 106-107
Jasarevic, Howard, Misic, Beiting, Bale (CR20) 2017; 7
Frohlich (CR50) 2016; 56
Lynch, Pedersen (CR47) 2016; 375
Caporaso (CR71) 2010; 7
CR15
Zhu, Zheng, Liu, Zhang, Zhao (CR23) 2014; 219
Sharon, Sampson, Geschwind, Mazmanian (CR11) 2016; 167
Yung (CR38) 2003; 60
Darnaudery, Dutriez, Viltart, Morley-Fletcher, Maccari (CR57) 2004; 153
Brown (CR7) 2004; 61
Holloway (CR8) 2013; 33
Vanbesien-Mailliot (CR58) 2007; 32
Muguruza (CR28) 2014; 86
Willing, Vacharaksa, Croxen, Thanachayanont, Finlay (CR52) 2011; 6
Bajaj (CR68) 2016; 6
Savignac (CR40) 2016; 52
Wang (CR55) 2015; 301
Son (CR17) 2015; 10
CR25
Bekinschtein, Renner, Gonzalez, Weisstaub (CR24) 2013; 33
CR21
Giovanoli (CR22) 2016; 6
Bajaj (CR69) 2015; 5
CR62
Gonzalez-Maeso (CR35) 2007; 53
Freedman (CR1) 2003; 349
Desbonnet (CR51) 2015; 48
Moreno (CR29) 2011; 31
Vollenweider, Vollenweider-Scherpenhuyzen, Babler, Vogel, Hell (CR33) 1998; 9
Laukens, Brinkman, Raes, De Vos, Vandenabeele (CR64) 2016; 40
Bauman (CR10) 2014; 75
(CR54) 2014; 511
Volkmar, Pauls (CR2) 2003; 362
Wischhof, Irrsack, Dietz, Koch (CR32) 2015; 97
Pandey, Naik, Vakil (CR39) 2015; 52
M de la Fuente Revenga (61635_CR66) 2018; 388
M De Angelis (61635_CR16) 2013; 8
SM Collins (61635_CR49) 2012; 10
61635_CR48
F Zhu (61635_CR23) 2014; 219
P Bekinschtein (61635_CR24) 2013; 33
C Muguruza (61635_CR28) 2014; 86
61635_CR45
E Castro-Nallar (61635_CR13) 2015; 3
MD Bauman (61635_CR10) 2014; 75
KR Pandey (61635_CR39) 2015; 52
B Clancy (61635_CR63) 2007; 28
Y Wang (61635_CR55) 2015; 301
SV Lynch (61635_CR47) 2016; 375
K Honda (61635_CR46) 2016; 535
F De Vadder (61635_CR59) 2014; 156
TH McGlashan (61635_CR37) 2006; 163
FX Vollenweider (61635_CR33) 1998; 9
JS Lim (61635_CR19) 2017; 10
P Zheng (61635_CR42) 2016; 21
D Ibi (61635_CR65) 2017; 20
FR Volkmar (61635_CR2) 2003; 362
BD Semple (61635_CR67) 2013; 106-107
61635_CR34
HM Savignac (61635_CR40) 2016; 52
N Segata (61635_CR41) 2011; 12
G Sharon (61635_CR11) 2016; 167
T Holloway (61635_CR8) 2013; 33
61635_CR30
AS Brown (61635_CR6) 2005; 162
AS Brown (61635_CR7) 2004; 61
G Sharon (61635_CR56) 2019; 177
J Gonzalez-Maeso (61635_CR35) 2007; 53
AS Brown (61635_CR5) 2010; 167
EY Hsiao (61635_CR18) 2013; 155
C Muguruza (61635_CR27) 2013; 23
L Coretti (61635_CR43) 2018; 9
CC Vanbesien-Mailliot (61635_CR58) 2007; 32
JL Moreno (61635_CR29) 2011; 31
AC Kentner (61635_CR9) 2019; 44
JS Bajaj (61635_CR69) 2015; 5
S Giovanoli (61635_CR22) 2016; 6
61635_CR25
AR Yung (61635_CR38) 2003; 60
61635_CR21
JG Caporaso (61635_CR71) 2010; 7
Consortium. S. W. G.O.T.P.G (61635_CR54) 2014; 511
JS Bajaj (61635_CR68) 2016; 6
CJ Guo (61635_CR60) 2017; 168
EE Frohlich (61635_CR50) 2016; 56
61635_CR62
BP Willing (61635_CR52) 2011; 6
D Laukens (61635_CR64) 2016; 40
Q Wang (61635_CR70) 2007; 73
L Wischhof (61635_CR32) 2015; 97
R Freedman (61635_CR1) 2003; 349
SC Yudofsky (61635_CR3) 2009; 301
L Desbonnet (61635_CR51) 2015; 48
61635_CR15
JB Hanks (61635_CR36) 2013; 4
J Gonzalez-Maeso (61635_CR26) 2008; 452
JM Yano (61635_CR61) 2015; 161
Julio Plaza-Díaz (61635_CR44) 2019; 11
AS Brown (61635_CR4) 2001; 49
E Jasarevic (61635_CR20) 2017; 7
NV Malkova (61635_CR31) 2014; 111
DE Nichols (61635_CR53) 2016; 68
RH Yolken (61635_CR14) 2015; 41
JS Son (61635_CR17) 2015; 10
S Tamburini (61635_CR12) 2016; 22
M Darnaudery (61635_CR57) 2004; 153
References_xml – ident: CR45
– volume: 362
  start-page: 1133
  year: 2003
  end-page: 1141
  ident: CR2
  article-title: Autism
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)14471-6
– volume: 10
  year: 2017
  ident: CR19
  article-title: Modeling environmental risk factors of autism in mice induces IBD-related gut microbial dysbiosis and hyperserotonemia
  publication-title: Mol Brain
  doi: 10.1186/s13041-017-0292-0
– volume: 11
  start-page: 337
  issue: 2
  year: 2019
  ident: CR44
  article-title: Autism Spectrum Disorder (ASD) with and without Mental Regression is Associated with Changes in the Fecal Microbiota
  publication-title: Nutrients
  doi: 10.3390/nu11020337
– volume: 7
  year: 2017
  ident: CR20
  article-title: Stress during pregnancy alters temporal and spatial dynamics of the maternal and offspring microbiome in a sex-specific manner
  publication-title: Sci Rep
  doi: 10.1038/srep44182
– volume: 6
  start-page: e26988
  year: 2011
  ident: CR52
  article-title: Altering host resistance to infections through microbial transplantation
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0026988
– volume: 44
  start-page: 245
  year: 2019
  end-page: 258
  ident: CR9
  article-title: Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-018-0185-7
– volume: 22
  start-page: 713
  year: 2016
  end-page: 722
  ident: CR12
  article-title: The microbiome in early life: implications for health outcomes
  publication-title: Nat Med
  doi: 10.1038/nm.4142
– volume: 75
  start-page: 332
  year: 2014
  end-page: 341
  ident: CR10
  article-title: Activation of the maternal immune system during pregnancy alters behavioral development of rhesus monkey offspring
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2013.06.025
– volume: 452
  start-page: 93
  year: 2008
  end-page: 97
  ident: CR26
  article-title: Identification of a serotonin/glutamate receptor complex implicated in psychosis
  publication-title: Nature
  doi: 10.1038/nature06612
– volume: 33
  start-page: 15716
  year: 2013
  end-page: 15725
  ident: CR24
  article-title: Role of medial prefrontal cortex serotonin 2A receptors in the control of retrieval of recognition memory in rats
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2087-13.2013
– volume: 12
  year: 2011
  ident: CR41
  article-title: Metagenomic biomarker discovery and explanation
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-6-r60
– volume: 32
  start-page: 114
  year: 2007
  end-page: 124
  ident: CR58
  article-title: Prenatal stress has pro-inflammatory consequences on the immune system in adult rats
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2006.11.005
– volume: 161
  start-page: 264
  year: 2015
  end-page: 276
  ident: CR61
  article-title: Indigenous bacteria from the gut microbiota regulate host serotonin biosynthesis
  publication-title: Cell
  doi: 10.1016/j.cell.2015.02.047
– volume: 106-107
  start-page: 1
  year: 2013
  end-page: 16
  ident: CR67
  article-title: Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2013.04.001
– ident: CR25
– volume: 163
  start-page: 790
  year: 2006
  end-page: 799
  ident: CR37
  article-title: Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.2006.163.5.790
– volume: 52
  start-page: 120
  year: 2016
  end-page: 131
  ident: CR40
  article-title: Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-beta levels in male mice
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2015.10.007
– volume: 219
  start-page: 680
  year: 2014
  end-page: 686
  ident: CR23
  article-title: Minocycline alleviates behavioral deficits and inhibits microglial activation in the offspring of pregnant mice after administration of polyriboinosinic-polyribocytidilic acid
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2014.06.046
– volume: 10
  start-page: 735
  year: 2012
  end-page: 742
  ident: CR49
  article-title: The interplay between the intestinal microbiota and the brain
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2876
– volume: 56
  start-page: 140
  year: 2016
  end-page: 155
  ident: CR50
  article-title: Cognitive impairment by antibiotic-induced gut dysbiosis: Analysis of gut microbiota-brain communication
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2016.02.020
– ident: CR21
– volume: 167
  start-page: 915
  year: 2016
  end-page: 932
  ident: CR11
  article-title: The Central Nervous System and the Gut Microbiome
  publication-title: Cell
  doi: 10.1016/j.cell.2016.10.027
– volume: 167
  start-page: 261
  year: 2010
  end-page: 280
  ident: CR5
  article-title: Prenatal infection and schizophrenia: a review of epidemiologic and translational studies
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2009.09030361
– volume: 9
  start-page: 3146
  year: 2018
  ident: CR43
  article-title: Gut Microbiota Features in Young Children With Autism Spectrum Disorders
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.03146
– volume: 156
  start-page: 84
  year: 2014
  end-page: 96
  ident: CR59
  article-title: Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.016
– volume: 33
  start-page: 1088
  year: 2013
  end-page: 1098
  ident: CR8
  article-title: Prenatal Stress Induces Schizophrenia-Like Alterations of Serotonin 2A and Metabotropic Glutamate 2 Receptors in the Adult Offspring: Role of Maternal Immune System
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2331-12.2013
– ident: CR15
– volume: 4
  start-page: 33
  year: 2013
  end-page: 42
  ident: CR36
  article-title: Animal models of serotonergic psychedelics
  publication-title: ACS Chem Neurosci
  doi: 10.1021/cn300138m
– volume: 23
  start-page: 852
  year: 2013
  end-page: 864
  ident: CR27
  article-title: Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2012.10.006
– volume: 21
  start-page: 786
  year: 2016
  end-page: 796
  ident: CR42
  article-title: Gut microbiome remodeling induces depressive-like behaviors through a pathway mediated by the host’s metabolism
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2016.44
– volume: 162
  start-page: 767
  year: 2005
  end-page: 773
  ident: CR6
  article-title: Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.162.4.767
– volume: 49
  start-page: 473
  year: 2001
  end-page: 486
  ident: CR4
  article-title: Bennett Research Award. Prenatal rubella, premorbid abnormalities, and adult schizophrenia
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(01)01068-X
– volume: 31
  start-page: 1863
  year: 2011
  end-page: 1872
  ident: CR29
  article-title: Maternal Influenza Viral Infection Causes Schizophrenia-Like Alterations of 5-HT2A and mGlu2 Receptors in the Adult Offspring
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4230-10.2011
– volume: 60
  start-page: 21
  year: 2003
  end-page: 32
  ident: CR38
  article-title: Psychosis prediction: 12-month follow up of a high-risk (“prodromal”) group
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(02)00167-6
– volume: 168
  start-page: 517
  year: 2017
  end-page: 526 e518
  ident: CR60
  article-title: Discovery of Reactive Microbiota-Derived Metabolites that Inhibit Host Proteases
  publication-title: Cell
  doi: 10.1016/j.cell.2016.12.021
– volume: 52
  start-page: 7577
  year: 2015
  end-page: 7587
  ident: CR39
  article-title: Probiotics, prebiotics and synbiotics- a review
  publication-title: J Food Sci Technol
  doi: 10.1007/s13197-015-1921-1
– volume: 41
  start-page: 1153
  year: 2015
  end-page: 1161
  ident: CR14
  article-title: Metagenomic Sequencing Indicates That the Oropharyngeal Phageome of Individuals With Schizophrenia Differs From That of Controls
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu197
– volume: 7
  start-page: 335
  year: 2010
  end-page: 336
  ident: CR71
  article-title: QIIME allows analysis of high-throughput community sequencing data
  publication-title: Nat Methods
  doi: 10.1038/nmeth.f.303
– volume: 53
  start-page: 439
  year: 2007
  end-page: 452
  ident: CR35
  article-title: Hallucinogens Recruit Specific Cortical 5-HT(2A) Receptor-Mediated Signaling Pathways to Affect Behavior
  publication-title: Neuron
  doi: 10.1016/j.neuron.2007.01.008
– volume: 388
  start-page: 102
  year: 2018
  end-page: 117
  ident: CR66
  article-title: HDAC2-dependent Antipsychotic-like Effects of Chronic Treatment with the HDAC Inhibitor SAHA in Mice
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.07.010
– ident: CR30
– volume: 3
  start-page: e1140
  year: 2015
  ident: CR13
  article-title: Composition, taxonomy and functional diversity of the oropharynx microbiome in individuals with schizophrenia and controls
  publication-title: PeerJ
  doi: 10.7717/peerj.1140
– volume: 5
  year: 2015
  ident: CR69
  article-title: Gut Microbiota Alterations can predict Hospitalizations in Cirrhosis Independent of Diabetes Mellitus
  publication-title: Sci Rep
  doi: 10.1038/srep18559
– volume: 20
  start-page: 1247
  year: 2017
  end-page: 1259
  ident: CR65
  article-title: Antipsychotic-induced Hdac2 transcription via NF-kappaB leads to synaptic and cognitive side effects
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4616
– volume: 28
  start-page: 931
  year: 2007
  end-page: 937
  ident: CR63
  article-title: Extrapolating brain development from experimental species to humans
  publication-title: Neurotoxicology
  doi: 10.1016/j.neuro.2007.01.014
– volume: 61
  start-page: 774
  year: 2004
  end-page: 780
  ident: CR7
  article-title: Serologic evidence of prenatal influenza in the etiology of schizophrenia
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.8.774
– volume: 73
  start-page: 5261
  year: 2007
  end-page: 5267
  ident: CR70
  article-title: Naive Bayesian classifier for rapid assignment of rRNA sequences into the new bacterial taxonomy
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00062-07
– volume: 301
  start-page: 324
  year: 2009
  end-page: 326
  ident: CR3
  article-title: Contracting schizophrenia: lessons from the influenza epidemic of 1918–1919
  publication-title: JAMA
  doi: 10.1001/jama.2008.980
– volume: 6
  year: 2016
  ident: CR68
  article-title: Elderly patients have an altered gut-brain axis regardless of the presence of cirrhosis
  publication-title: Sci Rep
  doi: 10.1038/srep38481
– volume: 86
  start-page: 311
  year: 2014
  end-page: 318
  ident: CR28
  article-title: Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2014.08.009
– volume: 40
  start-page: 117
  year: 2016
  end-page: 132
  ident: CR64
  article-title: Heterogeneity of the gut microbiome in mice: guidelines for optimizing experimental design
  publication-title: FEMS Microbiol Rev
  doi: 10.1093/femsre/fuv036
– volume: 48
  start-page: 165
  year: 2015
  end-page: 173
  ident: CR51
  article-title: Gut microbiota depletion from early adolescence in mice: Implications for brain and behaviour
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2015.04.004
– volume: 177
  start-page: 1600
  year: 2019
  end-page: 1618 e1617
  ident: CR56
  article-title: Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.004
– volume: 349
  start-page: 1738
  year: 2003
  end-page: 1749
  ident: CR1
  article-title: Schizophrenia
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra035458
– volume: 111
  start-page: E2492
  year: 2014
  end-page: 2500
  ident: CR31
  article-title: Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1323287111
– ident: CR48
– volume: 375
  start-page: 2369
  year: 2016
  end-page: 2379
  ident: CR47
  article-title: The Human Intestinal Microbiome in Health and Disease
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1600266
– volume: 301
  start-page: 363
  year: 2015
  end-page: 374
  ident: CR55
  article-title: Prenatal chronic mild stress induces depression-like behavior and sex-specific changes in regional glutamate receptor expression patterns in adult rats
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2015.06.008
– volume: 6
  year: 2016
  ident: CR22
  article-title: Preventive effects of minocycline in a neurodevelopmental two-hit model with relevance to schizophrenia
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2016.38
– volume: 10
  start-page: e0137725
  year: 2015
  ident: CR17
  article-title: Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0137725
– volume: 8
  start-page: e76993
  year: 2013
  ident: CR16
  article-title: Fecal microbiota and metabolome of children with autism and pervasive developmental disorder not otherwise specified
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0076993
– volume: 68
  start-page: 264
  year: 2016
  end-page: 355
  ident: CR53
  article-title: Psychedelics
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.115.011478
– volume: 9
  start-page: 3897
  year: 1998
  end-page: 3902
  ident: CR33
  article-title: Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action
  publication-title: Neuroreport
  doi: 10.1097/00001756-199812010-00024
– ident: CR34
– volume: 97
  start-page: 275
  year: 2015
  end-page: 288
  ident: CR32
  article-title: Maternal lipopolysaccharide treatment differentially affects 5-HT and mGlu2/3 receptor function in the adult male and female rat offspring
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2015.05.029
– volume: 511
  start-page: 421
  year: 2014
  end-page: 427
  ident: CR54
  article-title: Biological insights from 108 schizophrenia-associated genetic loci
  publication-title: Nature
  doi: 10.1038/nature13595
– volume: 153
  start-page: 211
  year: 2004
  end-page: 216
  ident: CR57
  article-title: Stress during gestation induces lasting effects on emotional reactivity of the dam rat
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2003.12.001
– ident: CR62
– volume: 155
  start-page: 1451
  year: 2013
  end-page: 1463
  ident: CR18
  article-title: Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.024
– volume: 535
  start-page: 75
  year: 2016
  end-page: 84
  ident: CR46
  article-title: The microbiota in adaptive immune homeostasis and disease
  publication-title: Nature
  doi: 10.1038/nature18848
– volume: 60
  start-page: 21
  year: 2003
  ident: 61635_CR38
  publication-title: Schizophr Res
  doi: 10.1016/S0920-9964(02)00167-6
– volume: 167
  start-page: 261
  year: 2010
  ident: 61635_CR5
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.2009.09030361
– volume: 68
  start-page: 264
  year: 2016
  ident: 61635_CR53
  publication-title: Pharmacol Rev
  doi: 10.1124/pr.115.011478
– volume: 49
  start-page: 473
  year: 2001
  ident: 61635_CR4
  publication-title: Biol Psychiatry
  doi: 10.1016/S0006-3223(01)01068-X
– volume: 21
  start-page: 786
  year: 2016
  ident: 61635_CR42
  publication-title: Mol Psychiatry
  doi: 10.1038/mp.2016.44
– volume: 6
  year: 2016
  ident: 61635_CR22
  publication-title: Transl Psychiatry
  doi: 10.1038/tp.2016.38
– ident: 61635_CR25
  doi: 10.7554/eLife.33746
– volume: 52
  start-page: 7577
  year: 2015
  ident: 61635_CR39
  publication-title: J Food Sci Technol
  doi: 10.1007/s13197-015-1921-1
– volume: 53
  start-page: 439
  year: 2007
  ident: 61635_CR35
  publication-title: Neuron
  doi: 10.1016/j.neuron.2007.01.008
– volume: 6
  year: 2016
  ident: 61635_CR68
  publication-title: Sci Rep
  doi: 10.1038/srep38481
– volume: 12
  year: 2011
  ident: 61635_CR41
  publication-title: Genome Biol
  doi: 10.1186/gb-2011-12-6-r60
– volume: 349
  start-page: 1738
  year: 2003
  ident: 61635_CR1
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra035458
– volume: 10
  start-page: 735
  year: 2012
  ident: 61635_CR49
  publication-title: Nat Rev Microbiol
  doi: 10.1038/nrmicro2876
– volume: 168
  start-page: 517
  year: 2017
  ident: 61635_CR60
  publication-title: Cell
  doi: 10.1016/j.cell.2016.12.021
– ident: 61635_CR30
  doi: 10.1016/j.neures.2015.07.002
– volume: 162
  start-page: 767
  year: 2005
  ident: 61635_CR6
  publication-title: Am J Psychiatry
  doi: 10.1176/appi.ajp.162.4.767
– volume: 156
  start-page: 84
  year: 2014
  ident: 61635_CR59
  publication-title: Cell
  doi: 10.1016/j.cell.2013.12.016
– volume: 301
  start-page: 324
  year: 2009
  ident: 61635_CR3
  publication-title: JAMA
  doi: 10.1001/jama.2008.980
– volume: 7
  start-page: 335
  year: 2010
  ident: 61635_CR71
  publication-title: Nat Methods
  doi: 10.1038/nmeth.f.303
– ident: 61635_CR45
  doi: 10.3390/ma11071129
– volume: 511
  start-page: 421
  year: 2014
  ident: 61635_CR54
  publication-title: Nature
  doi: 10.1038/nature13595
– ident: 61635_CR62
  doi: 10.1038/nature23874
– volume: 9
  start-page: 3146
  year: 2018
  ident: 61635_CR43
  publication-title: Front Microbiol
  doi: 10.3389/fmicb.2018.03146
– volume: 44
  start-page: 245
  year: 2019
  ident: 61635_CR9
  publication-title: Neuropsychopharmacology
  doi: 10.1038/s41386-018-0185-7
– volume: 6
  start-page: e26988
  year: 2011
  ident: 61635_CR52
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0026988
– volume: 75
  start-page: 332
  year: 2014
  ident: 61635_CR10
  publication-title: Biol Psychiatry
  doi: 10.1016/j.biopsych.2013.06.025
– volume: 153
  start-page: 211
  year: 2004
  ident: 61635_CR57
  publication-title: Behav Brain Res
  doi: 10.1016/j.bbr.2003.12.001
– ident: 61635_CR21
  doi: 10.1038/nature23910
– volume: 41
  start-page: 1153
  year: 2015
  ident: 61635_CR14
  publication-title: Schizophr Bull
  doi: 10.1093/schbul/sbu197
– volume: 52
  start-page: 120
  year: 2016
  ident: 61635_CR40
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2015.10.007
– volume: 23
  start-page: 852
  year: 2013
  ident: 61635_CR27
  publication-title: Eur Neuropsychopharmacol
  doi: 10.1016/j.euroneuro.2012.10.006
– volume: 86
  start-page: 311
  year: 2014
  ident: 61635_CR28
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2014.08.009
– volume: 33
  start-page: 1088
  year: 2013
  ident: 61635_CR8
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2331-12.2013
– volume: 155
  start-page: 1451
  year: 2013
  ident: 61635_CR18
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.024
– volume: 452
  start-page: 93
  year: 2008
  ident: 61635_CR26
  publication-title: Nature
  doi: 10.1038/nature06612
– volume: 167
  start-page: 915
  year: 2016
  ident: 61635_CR11
  publication-title: Cell
  doi: 10.1016/j.cell.2016.10.027
– volume: 48
  start-page: 165
  year: 2015
  ident: 61635_CR51
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2015.04.004
– volume: 61
  start-page: 774
  year: 2004
  ident: 61635_CR7
  publication-title: Arch Gen Psychiatry
  doi: 10.1001/archpsyc.61.8.774
– volume: 111
  start-page: E2492
  year: 2014
  ident: 61635_CR31
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.1323287111
– ident: 61635_CR48
  doi: 10.1016/j.pbb.2017.06.016
– volume: 32
  start-page: 114
  year: 2007
  ident: 61635_CR58
  publication-title: Psychoneuroendocrinology
  doi: 10.1016/j.psyneuen.2006.11.005
– volume: 33
  start-page: 15716
  year: 2013
  ident: 61635_CR24
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.2087-13.2013
– ident: 61635_CR34
  doi: 10.1016/j.biopsych.2014.11.015
– volume: 56
  start-page: 140
  year: 2016
  ident: 61635_CR50
  publication-title: Brain Behav Immun
  doi: 10.1016/j.bbi.2016.02.020
– volume: 40
  start-page: 117
  year: 2016
  ident: 61635_CR64
  publication-title: FEMS Microbiol Rev
  doi: 10.1093/femsre/fuv036
– volume: 219
  start-page: 680
  year: 2014
  ident: 61635_CR23
  publication-title: Psychiatry Res
  doi: 10.1016/j.psychres.2014.06.046
– volume: 535
  start-page: 75
  year: 2016
  ident: 61635_CR46
  publication-title: Nature
  doi: 10.1038/nature18848
– volume: 163
  start-page: 790
  year: 2006
  ident: 61635_CR37
  publication-title: Am J Psychiatry
  doi: 10.1176/ajp.2006.163.5.790
– volume: 20
  start-page: 1247
  year: 2017
  ident: 61635_CR65
  publication-title: Nat Neurosci
  doi: 10.1038/nn.4616
– volume: 11
  start-page: 337
  issue: 2
  year: 2019
  ident: 61635_CR44
  publication-title: Nutrients
  doi: 10.3390/nu11020337
– volume: 362
  start-page: 1133
  year: 2003
  ident: 61635_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(03)14471-6
– volume: 388
  start-page: 102
  year: 2018
  ident: 61635_CR66
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2018.07.010
– volume: 73
  start-page: 5261
  year: 2007
  ident: 61635_CR70
  publication-title: Appl Environ Microbiol
  doi: 10.1128/AEM.00062-07
– volume: 4
  start-page: 33
  year: 2013
  ident: 61635_CR36
  publication-title: ACS Chem Neurosci
  doi: 10.1021/cn300138m
– volume: 5
  year: 2015
  ident: 61635_CR69
  publication-title: Sci Rep
  doi: 10.1038/srep18559
– volume: 106-107
  start-page: 1
  year: 2013
  ident: 61635_CR67
  publication-title: Prog Neurobiol
  doi: 10.1016/j.pneurobio.2013.04.001
– ident: 61635_CR15
  doi: 10.1016/j.schres.2018.01.002
– volume: 161
  start-page: 264
  year: 2015
  ident: 61635_CR61
  publication-title: Cell
  doi: 10.1016/j.cell.2015.02.047
– volume: 7
  year: 2017
  ident: 61635_CR20
  publication-title: Sci Rep
  doi: 10.1038/srep44182
– volume: 97
  start-page: 275
  year: 2015
  ident: 61635_CR32
  publication-title: Neuropharmacology
  doi: 10.1016/j.neuropharm.2015.05.029
– volume: 31
  start-page: 1863
  year: 2011
  ident: 61635_CR29
  publication-title: J Neurosci
  doi: 10.1523/JNEUROSCI.4230-10.2011
– volume: 8
  start-page: e76993
  year: 2013
  ident: 61635_CR16
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0076993
– volume: 10
  year: 2017
  ident: 61635_CR19
  publication-title: Mol Brain
  doi: 10.1186/s13041-017-0292-0
– volume: 10
  start-page: e0137725
  year: 2015
  ident: 61635_CR17
  publication-title: PloS ONE
  doi: 10.1371/journal.pone.0137725
– volume: 22
  start-page: 713
  year: 2016
  ident: 61635_CR12
  publication-title: Nat Med
  doi: 10.1038/nm.4142
– volume: 375
  start-page: 2369
  year: 2016
  ident: 61635_CR47
  publication-title: N Engl J Med
  doi: 10.1056/NEJMra1600266
– volume: 301
  start-page: 363
  year: 2015
  ident: 61635_CR55
  publication-title: Neuroscience
  doi: 10.1016/j.neuroscience.2015.06.008
– volume: 177
  start-page: 1600
  year: 2019
  ident: 61635_CR56
  publication-title: Cell
  doi: 10.1016/j.cell.2019.05.004
– volume: 28
  start-page: 931
  year: 2007
  ident: 61635_CR63
  publication-title: Neurotoxicology
  doi: 10.1016/j.neuro.2007.01.014
– volume: 3
  start-page: e1140
  year: 2015
  ident: 61635_CR13
  publication-title: PeerJ
  doi: 10.7717/peerj.1140
– volume: 9
  start-page: 3897
  year: 1998
  ident: 61635_CR33
  publication-title: Neuroreport
  doi: 10.1097/00001756-199812010-00024
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Snippet Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental...
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SubjectTerms 631/136/1425
631/326/2565/2134
631/378/1689/1799
64/60
Age Factors
Animals
Anti-Bacterial Agents - administration & dosage
Antibiotics
Autism
Behavior
Behavior, Animal
Brain injury
Cognitive ability
Cortex (frontal)
Disease Models, Animal
Disease Susceptibility
Gastrointestinal Microbiome
Gut microbiota
Gut-brain axis
Humanities and Social Sciences
Immune response
Immune system
Influenza
Intestinal microflora
Memory
Mental disorders
Mice
Microbiota
multidisciplinary
Neurodevelopmental disorders
Neurodevelopmental Disorders - etiology
Neurodevelopmental Disorders - psychology
Offspring
Pattern recognition
Phenotype
Phenotypes
Pregnancy
Problem Behavior
Receptor density
Recognition, Psychology
Relative abundance
Schizophrenia
Schizophrenia - etiology
Science
Science (multidisciplinary)
Serotonin S2 receptors
Sexual Maturation
Transplantation
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Title Gut microbiota manipulation during the prepubertal period shapes behavioral abnormalities in a mouse neurodevelopmental disorder model
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https://www.ncbi.nlm.nih.gov/pubmed/32170216
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Volume 10
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