Ocular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis

• Published in: Scientific reports Vol. 11; no. 1; pp. 6172 - 8
• Main Authors: Lee, Byung Joo, Lee, Kihwang, Chung, Seung Ah, Lim, Hyun Taek
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 17.03.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 692/308/3187; 692/699/3161/3174; Age; Biometrics; Children; Cornea; Cranial sutures; Craniosynostosis; Eye; Fibroblast growth factor receptors; Fibroblasts; Growth factors; Humanities and Social Sciences; multidisciplinary; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-021-85620-9

Ametropia is reported as a common ophthalmic manifestation in craniosynostosis. We retrospectively compared childhood refractive error and ocular biometric features of fibroblast growth factor receptor (FGFR)-related syndromic craniosynostosis patients with those of non-syndromic craniosynostosis and control subjects. Thirty-six eyes (18 patients) with FGFR-related syndromic craniosynostosis, 76 eyes (38 patients) with non-syndromic craniosynostosis, and 114 eyes (57 patients) of intermittent exotropes were included in the analysis. Mean age at examination was 7.82 ± 2.51 (range, 4–16) years and mean spherical equivalent was -0.09 ± 1.46 Diopter. Mean age and refractive error were not different between groups, but syndromic craniosynostosis patients had significantly longer axial length, lower corneal power, and lower lens power than other groups ( p  < 0.01, p  < 0.01, and p  < 0.01, respectively). Axial length was positively correlated and keratometry and lens power were negatively correlated with age in non-syndromic craniosynostosis and controls, while these correlations between age and ocular biometric parameters were not present in the FGFR-related syndromic craniosynostosis. In conclusion, ocular biometric parameters in FGFR-related syndromic craniosynostosis differed from those of non-syndromic craniosynostosis and age-matched controls, and did not show the relations with age, suggesting this cohort may have abnormal refractive growth.