Primary effusion lymphoma enhancer connectome links super-enhancers to dependency factors

• Published in: Nature communications Vol. 11; no. 1; pp. 6318 - 13
• Main Authors: Wang, Chong, Zhang, Luyao, Ke, Liangru, Ding, Weiyue, Jiang, Sizun, Li, Difei, Narita, Yohei, Hou, Isabella, Liang, Jun, Li, Shijun, Xiao, Haipeng, Gottwein, Eva, Kaye, Kenneth M., Teng, Mingxiang, Zhao, Bo
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.12.2020; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/106; 13/109; 38/1; 38/43; 38/61; 38/77; 38/88; 45; 45/15; 45/22; 631/1647/2210/2211; 631/337/100/101; 631/337/100/102; 631/337/176/2016; 64; 96; Cell growth; Cell Line, Tumor; Cell Proliferation - genetics; Cell survival; Chromatin Immunoprecipitation Sequencing; CRISPR; Dependence; Effusion; Enhancer Elements, Genetic - genetics; Enhancers; Gene expression; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Gene Regulatory Networks; Genomes; Herpesvirus 8, Human - pathogenicity; Histones - genetics; Humanities and Social Sciences; Humans; Interferon regulatory factor 4; Interferon Regulatory Factors - genetics; Links; Lymphoma; Lymphoma, Primary Effusion - genetics; Lymphoma, Primary Effusion - pathology; Lymphoma, Primary Effusion - virology; Mcl-1 protein; MDM2 protein; Medical prognosis; MEF2 Transcription Factors - genetics; MEF2 Transcription Factors - metabolism; multidisciplinary; Myc protein; Pathogenesis; Perturbation; Primary effusion lymphoma; Prognosis; Promoter Regions, Genetic - genetics; Promoters; Proto-Oncogene Proteins c-myc - genetics; Repressors; Science; Science (multidisciplinary); Tethering; Transcription factors

Primary effusion lymphoma (PEL) has a very poor prognosis. To evaluate the contributions of enhancers/promoters interactions to PEL cell growth and survival, here we produce H3K27ac HiChIP datasets in PEL cells. This allows us to generate the PEL enhancer connectome, which links enhancers and promot...