Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma - Gonzalez-Meljem, Jose Mario; Haston, Scott; Carreno, Gabriela; Apps, John R.; Pozzi, Sara; Stache, Christina; Kaushal, Grace; Virasami, Alex; Panousopoulos, Leonidas; Mousavy-Gharavy, Seyedeh Neda; Guerrero, Ana; Rashid, Mamunur; et al. (Nature communications, 2017)
Keywords: 631/67/71; 692/4028/67/2332; Age; Aniline Compounds - pharmacology; Animal models; Animals; beta Catenin - metabolism; Biphenyl Compounds - pharmacology; Bone cancer; Brain cancer; Brain tumors; Cell Transformation, Neoplastic; Cellular Senescence - physiology; Child; Clusters; Craniopharyngioma - metabolism; Craniopharyngioma - pathology; Disease Models, Animal; Embryos; Exome Sequencing; Genetic transformation; Homeodomain Proteins - metabolism; Humanities and Social Sciences; Humans; Mice; multidisciplinary; Neoplasia; Neoplastic Stem Cells - metabolism; Nitrophenols - pharmacology; Oncogenes - physiology; Paracrine signalling; Piperazines - pharmacology; Pituitary; Pituitary gland; Pituitary Gland - metabolism; Pituitary Gland - pathology; Pituitary Neoplasms - metabolism; Pituitary Neoplasms - pathology; Repressor Proteins - metabolism; Science; Science (multidisciplinary); Senescence; SOXB1 Transcription Factors - metabolism; Stem cell transplantation; Stem cells; Sulfonamides - pharmacology; Tumorigenesis; Tumors; Young Adult; β-Catenin