DNMT3A-mediated silence in ADAMTS9 expression is restored by RNF180 to inhibit viability and motility in gastric cancer cells

• Published in: Cell death & disease Vol. 12; no. 5; pp. 428 - 12
• Main Authors: Sun, Weilin, Ma, Gang, Zhang, Li, Wang, Pengliang, Zhang, Nannan, Wu, Zizhen, Dong, Yinping, Cai, Fenglin, Chen, Liqiao, Liu, Huifang, liang, Han, Deng, Jingyu
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 30.04.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 13/51; 38/77; 38/90; 631/67/1504/1829; 631/80/84/2336; 82/80; ADAM protein; Antibodies; Biochemistry; Biomedical and Life Sciences; Cell Biology; Cell Culture; Cell viability; DNA methyltransferase; Gastric cancer; Gene expression; Immunology; Life Sciences; Motility; Mucosa; Phenotypes; Proteasomes; Proteins; Signal transduction; Thrombospondin

ADAMTS9 belongs to the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family, and its expression is frequently silenced due to promoter hypermethylation in various human cancers. However, the underlying mechanisms remain largely unknown. In this study, we investigate...