Mapping optogenetically-driven single-vessel fMRI with concurrent neuronal calcium recordings in the rat hippocampus

• Published in: Nature communications Vol. 10; no. 1; pp. 5239 - 12
• Main Authors: Chen, Xuming, Sobczak, Filip, Chen, Yi, Jiang, Yuanyuan, Qian, Chunqi, Lu, Zuneng, Ayata, Cenk, Logothetis, Nikos K., Yu, Xin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 20.11.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 59/57; 631/1647/2253; 631/1647/245; 631/378/2607; Alzheimer's disease; Animal models; Animals; Arterioles; Blood; Blood vessels; Brain research; Calcium; Calcium (blood); Calcium - metabolism; Calcium ions; Calcium signalling; Cerebral Blood Volume; Cortex; Cortical Spreading Depression; Cybernetics; Electrophysiological recording; Evoked Potentials; Functional magnetic resonance imaging; Functional Neuroimaging; Hemodynamic responses; Hippocampus; Hippocampus - blood supply; Hippocampus - metabolism; Hospitals; Humanities and Social Sciences; In vivo methods and tests; Light; Magnetic Resonance Imaging; Mapping; Medical imaging; multidisciplinary; Neural networks; Neurons - metabolism; Neurosciences; Neurovascular Coupling; Optogenetics; Rats; Science; Science (multidisciplinary); Spreading depression; Venules

Extensive in vivo imaging studies investigate the hippocampal neural network function, mainly focusing on the dorsal CA1 region given its optical accessibility. Multi-modality fMRI with simultaneous hippocampal electrophysiological recording reveal broad cortical correlation patterns, but the detail...