Metabolic flexibility during sleep

Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respirato...

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Published inScientific reports Vol. 11; no. 1; pp. 17849 - 13
Main Authors Zhang, Simeng, Tanaka, Yoshiaki, Ishihara, Asuka, Uchizawa, Akiko, Park, Insung, Iwayama, Kaito, Ogata, Hitomi, Yajima, Katsuhiko, Omi, Naomi, Satoh, Makoto, Yanagisawa, Masashi, Sagayama, Hiroyuki, Tokuyama, Kumpei
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 08.09.2021
Nature Publishing Group
Nature Portfolio
Subjects
631/443/319
631/443/319/1557
631/443/319/1642
Age Factors
Blood Glucose - metabolism
Body Temperature - physiology
Calorimetry
Energy Intake - physiology
Energy Metabolism - physiology
Female
Heart Rate - physiology
Humanities and Social Sciences
Humans
Male
Metabolism
multidisciplinary
Respiratory quotient
Science
Science (multidisciplinary)
Sleep
Sleep - physiology
Young Adult
Young adults
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Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
AbstractList Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
ArticleNumber 17849
Author Tanaka, Yoshiaki
Tokuyama, Kumpei
Yanagisawa, Masashi
Uchizawa, Akiko
Zhang, Simeng
Park, Insung
Omi, Naomi
Iwayama, Kaito
Ogata, Hitomi
Ishihara, Asuka
Satoh, Makoto
Yajima, Katsuhiko
Sagayama, Hiroyuki
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  surname: Tanaka
  fullname: Tanaka, Yoshiaki
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  organization: Graduate School of Integrated Arts and Sciences, Hiroshima University
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  organization: Faculty of Pharmaceutical Sciences, Josai University
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  givenname: Kumpei
  orcidid: 0000-0003-1756-4227
  surname: Tokuyama
  fullname: Tokuyama, Kumpei
  email: tokuyama.kumpei.gf@u.tsukuba.ac.jp
  organization: International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34497320$$D View this record in MEDLINE/PubMed
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Snippet Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting,...
Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of...
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631/443/319/1557
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Age Factors
Blood Glucose - metabolism
Body Temperature - physiology
Calorimetry
Energy Intake - physiology
Energy Metabolism - physiology
Female
Heart Rate - physiology
Humanities and Social Sciences
Humans
Male
Metabolism
multidisciplinary
Respiratory quotient
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Science (multidisciplinary)
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Sleep - physiology
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Title Metabolic flexibility during sleep
URI https://link.springer.com/article/10.1038/s41598-021-97301-8
https://www.ncbi.nlm.nih.gov/pubmed/34497320
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Volume 11
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