A polyphenol extract modifies quantity but not quality of liver fatty acid content in high-fat–high-sucrose diet-fed rats: possible implication of the sirtuin pathway

• Published in: British journal of nutrition Vol. 104; no. 12; pp. 1760 - 1770
• Main Authors: Aoun, Manar, Michel, Francoise, Fouret, Gilles, Casas, Francois, Jullien, Melanie, Wrutniak-Cabello, Chantal, Ramos, Jeanne, Cristol, Jean-Paul, Coudray, Charles, Carbonneau, Marie-Annette, Feillet-Coudray, Christine
• Format: Journal Article
• Language: English
• Published: Cambridge, UK Cambridge University Press 28.12.2010; Cambridge University Press (CUP)
• Subjects: acetyl-CoA carboxylase; animal models; animal proteins; Animals; biochemical pathways; Biological and medical sciences; Diet; Dietary Fats - administration & dosage; Dietary Fats - adverse effects; Dietary Sucrose - administration & dosage; Dietary Sucrose - adverse effects; enzyme activity; experimental diets; Fatty acids; Fatty Acids - metabolism; fatty liver; Fatty Liver - chemically induced; Feeding. Feeding behavior; Flavonoids - chemistry; Flavonoids - pharmacology; Food and Nutrition; fruit extracts; Fundamental and applied biological sciences. Psychology; gene expression; genes; grapes; high fat diet; High-fat–high-sucrose diet; human diseases; human nutrition; kinases; Life Sciences; Liver; Liver - metabolism; Male; Metabolism and Metabolic Studies; Mitochondria; non-alcoholic fatty liver disease; Nutrition research; Oxidative stress; Phenols - chemistry; Phenols - pharmacology; phospho-acetyl-CoA carboxylase; phosphorylated AMP kinase; phytochemicals; Plant Extracts - chemistry; Plant Extracts - pharmacology; Polyphenols; protein synthesis; Proteins; Random Allocation; Rats; Rats, Wistar; RNA, Messenger - genetics; RNA, Messenger - metabolism; Rodents; Sirtuin 1 - metabolism; Sirtuin-1; sirtuin-1 deacetylase; stearoyl-CoA desaturase; Sucrose; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Sirtuin-1; Polyphenols; Oxidative stress; Mitochondria; Fatty acids; High-fat–high-sucrose diet; Rat; Sucrose; Rodentia; Lipids; Hepatic disease; Quantity; Fat content; Extract; Feeding; Vertebrata; Polyphenol; High-fat-high-sucrose diet; Mammalia; Fatty liver; Diet; Animal; Quality; Fat; Digestive diseases; POLYPHENOLS; OXIDATIVE STRESS; RAT; MITOCHONDRIA; FATTY ACIDS; SIRTUIN-1; HIGH-FAT–HIGH-SUCROSE DIET

High-fat or high-fat–high-sucrose diets are known to induce non-alcoholic fatty liver disease and this is emerging as one of the most common liver diseases worldwide. Some polyphenols have been reported to decrease rat hepatic lipid accumulation, in particular those extracted from red grapes such as...