Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy

In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action lim...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 17; no. 3; p. 329
Main Authors Patel, Priya, Garala, Kevinkumar, Singh, Sudarshan, Prajapati, Bhupendra G., Chittasupho, Chuda
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.03.2024
MDPI
Subjects
bioactive compound
Bioavailability
Biocompatibility
Chemical properties
Chromatography
drug delivery
Drug delivery systems
Drugs
Evaluation
Extracellular vesicles
Flavonoids
Health aspects
Herbal medicine
Identification
Laboratories
lipid-based nanoparticles
Lipids
Materials
Metabolites
Nanoparticles
Nanotechnology
Natural products
Pharmaceuticals
Phytochemicals
Polyphenols
Regulatory approval
Review
therapeutic efficacy
Vehicles
India
nanotechnology
drug delivery
lipid-based nanoparticles
bioactive compound
therapeutic efficacy
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Abstract In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.
AbstractList In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds’ physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.
In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds' physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their limited solubility, low bioavailability, inadequate gastrointestinal tract stability, high metabolic rate, and shorter duration of action limited their pharmaceutical applications. However, those can be improved using nanotechnology to create various drug delivery systems, including lipid-based nanoparticles, to adjust the compounds' physicochemical properties and pharmacokinetic profile. Because of the enormous technical advancements made in the fundamental sciences and the physical and chemical manipulation of individual atoms and molecules, the subject of nanotechnology has experienced revolutionary growth. By fabricating certain functionalized particles, nanotechnology opens an innovative horizon in research and development for overcoming restrictions, including traditional medication administration systems. Nanotechnology-driven bioactive compounds are certain to have a high impact and clinical value for current and future uses. Lipid-based nanotechnologies were shown to deliver a range of naturally occurring bioactive compounds with decent entrapment potential and stability, a successfully controlled release, increased bioavailability, and intriguing therapeutic activity. This review outlines bioactive compounds such as paclitaxel, curcumin, rhodomyrtone, quercetin, kaempferol, resveratrol, epigallocatechin-3-gallate, silymarin, and oridonin, fortified within either a natural or synthetic lipid-based drug delivery system based on nanotechnology and their evaluation and clinical considerations.
Audience Academic
Author Singh, Sudarshan
Garala, Kevinkumar
Prajapati, Bhupendra G.
Patel, Priya
Chittasupho, Chuda
AuthorAffiliation 2 School of Pharmaceutical Sciences, Atmiya University, Rajkot 360005, Gujarat, India; kevin.garala@atmiyauni.ac.in
4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
3 Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand; sudarshansingh83@hotmail.com
1 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot 360005, Gujarat, India
5 Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva 384012, Gujarat, India
AuthorAffiliation_xml – name: 2 School of Pharmaceutical Sciences, Atmiya University, Rajkot 360005, Gujarat, India; kevin.garala@atmiyauni.ac.in
– name: 4 Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
– name: 3 Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand; sudarshansingh83@hotmail.com
– name: 1 Department of Pharmaceutical Sciences, Saurashtra University, Rajkot 360005, Gujarat, India
– name: 5 Shree S. K. Patel College of Pharmaceutical Education and Research, Ganpat University, Kherva 384012, Gujarat, India
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Snippet In recent years, due to their distinctive and adaptable therapeutic effects, many natural bioactive compounds have been commonly used to treat diseases. Their...
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SubjectTerms bioactive compound
Bioavailability
Biocompatibility
Chemical properties
Chromatography
drug delivery
Drug delivery systems
Drugs
Evaluation
Extracellular vesicles
Flavonoids
Health aspects
Herbal medicine
Identification
Laboratories
lipid-based nanoparticles
Lipids
Materials
Metabolites
Nanoparticles
Nanotechnology
Natural products
Pharmaceuticals
Phytochemicals
Polyphenols
Regulatory approval
Review
therapeutic efficacy
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Title Lipid-Based Nanoparticles in Delivering Bioactive Compounds for Improving Therapeutic Efficacy
URI https://www.ncbi.nlm.nih.gov/pubmed/38543115
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Volume 17
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