Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging

Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation...

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Published in	Nature communications Vol. 11; no. 1; pp. 3102 - 11
Main Authors	Li, Benhao, Zhao, Mengyao, Feng, Lishuai, Dou, Chaoran, Ding, Suwan, Zhou, Gang, Lu, Lingfei, Zhang, Hongxin, Chen, Feiya, Li, Xiaomin, Li, Guangfeng, Zhao, Shichang, Jiang, Chunyu, Wang, Yan, Zhao, Dongyuan, Cheng, Yingsheng, Zhang, Fan
Format	Journal Article
Language	English
Published	London Nature Publishing Group UK 18.06.2020 Nature Publishing Group Nature Portfolio
Subjects	59 639/638/11/874 639/638/11/942 692/699/75/593 Absorption Animals Blood circulation Blood vessels Blood-brain barrier Carotid Arteries - diagnostic imaging Carotid artery Contrast agents Emission analysis Emissions Female Fluorescent Dyes Half-life Hindlimb - diagnostic imaging Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans I.R. radiation Ischemia Laboratories Lymphatic system Medical imaging Mice, Nude Monitoring multidisciplinary Near infrared radiation Neuroimaging Optical properties Pharmacokinetics Real time Reperfusion Reperfusion Injury - diagnostic imaging Science Science (multidisciplinary) Thrombolysis Thrombolytic drugs Thrombosis - diagnostic imaging Ultrasonic imaging Vascular Diseases - diagnostic imaging Veins & arteries Wavelength
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Abstract	Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes.
AbstractList	Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes. Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5–60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes. Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties.Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window provides advantages including high resolution and fast feedback. However, the reported molecular dyes are hampered by limited blood circulation time (~ 5-60 min) and short absorption and emission wavelength, which impede the accurate long-term monitoring. Here, we report a NIR-II molecule (LZ-1105) with absorption and emission beyond 1000 nm. Thanks to the long blood circulation time (half-life of 3.2 h), the fluorophore is used for continuous real-time monitoring of dynamic vascular processes, including ischemic reperfusion in hindlimbs, thrombolysis in carotid artery and opening and recovery of the blood brain barrier (BBB). LZ-1105 provides an approach for researchers to assess vessel dysfunction due to the long excitation and emission wavelength and long-term blood circulation properties. Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule with long blood circulation half-life time for continuous real-time monitoring of dynamic vascular processes.
ArticleNumber	3102
Author	Li, Benhao Li, Guangfeng Ding, Suwan Zhao, Shichang Li, Xiaomin Zhao, Dongyuan Zhang, Fan Feng, Lishuai Zhou, Gang Wang, Yan Jiang, Chunyu Lu, Lingfei Dou, Chaoran Chen, Feiya Zhang, Hongxin Cheng, Yingsheng Zhao, Mengyao
Author_xml	– sequence: 1 givenname: Benhao surname: Li fullname: Li, Benhao organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 2 givenname: Mengyao surname: Zhao fullname: Zhao, Mengyao organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 3 givenname: Lishuai surname: Feng fullname: Feng, Lishuai organization: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital – sequence: 4 givenname: Chaoran surname: Dou fullname: Dou, Chaoran organization: Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital – sequence: 5 givenname: Suwan orcidid: 0000-0001-6259-9897 surname: Ding fullname: Ding, Suwan organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 6 givenname: Gang orcidid: 0000-0002-1533-7795 surname: Zhou fullname: Zhou, Gang organization: Lab of Advanced Materials & Department of Macromolecular Science, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University – sequence: 7 givenname: Lingfei surname: Lu fullname: Lu, Lingfei organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 8 givenname: Hongxin surname: Zhang fullname: Zhang, Hongxin organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 9 givenname: Feiya surname: Chen fullname: Chen, Feiya organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 10 givenname: Xiaomin orcidid: 0000-0001-6056-6928 surname: Li fullname: Li, Xiaomin organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 11 givenname: Guangfeng surname: Li fullname: Li, Guangfeng organization: Lab of Advanced Materials & Department of Macromolecular Science, Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University – sequence: 12 givenname: Shichang surname: Zhao fullname: Zhao, Shichang organization: Department of Orthopedics, Shanghai Sixth People’s Hospital, Shanghai Jiao Tong University – sequence: 13 givenname: Chunyu surname: Jiang fullname: Jiang, Chunyu organization: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital – sequence: 14 givenname: Yan surname: Wang fullname: Wang, Yan organization: Department of Ultrasound in Medicine, Shanghai Institute of Ultrasound in Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital – sequence: 15 givenname: Dongyuan orcidid: 0000-0001-8440-6902 surname: Zhao fullname: Zhao, Dongyuan organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University – sequence: 16 givenname: Yingsheng surname: Cheng fullname: Cheng, Yingsheng organization: Department of Radiology, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital – sequence: 17 givenname: Fan orcidid: 0000-0001-7886-6144 surname: Zhang fullname: Zhang, Fan email: zhang_fan@fudan.edu.cn organization: Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32555157$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1038/ncomms3199 10.1016/S0140-6736(13)62388-0 10.1148/radiol.2202001804 10.1002/adma.201808355 10.1016/j.toxlet.2008.07.020 10.1002/anie.201812878 10.1371/journal.pone.0187563 10.1002/adma.201706856 10.1002/adhm.201801650 10.1021/acs.jmedchem.8b01682 10.1038/nm.2995 10.1038/s41551-017-0056 10.1074/jbc.M114.548115 10.1021/nn301218z 10.1038/206632b0 10.1002/adhm.201800589 10.1056/NEJMra0801082 10.1038/nrcardio.2016.166 10.1039/C7SC00251C 10.1038/ncomms14702 10.1002/anie.201904182 10.1002/anie.201903536 10.1002/anie.201801226 10.1038/s41467-019-09043-x 10.1161/01.STR.0000173152.84438.1c 10.2174/1567202615666180717113526 10.1038/s41467-018-05113-8 10.1039/C4CC06542E 10.1038/nmat4476 10.1038/nbt1340 10.1097/MD.0000000000013216 10.1073/pnas.1718917115 10.1073/pnas.1521175113 10.1002/adfm.201803417 10.1021/acs.nanolett.8b01818 10.1161/ATVBAHA.110.202796 10.1021/jacs.9b10043 10.1007/978-0-387-45524-2 10.1002/anie.201507473 10.1117/1.JBO.20.3.030901 10.1002/adma.201802546 10.1038/nphoton.2014.166 10.1177/1538574410363747 10.7150/thno.12494 10.1038/ncomms15269 10.1039/C8CS00001H 10.1002/anie.201407420 10.1002/adom.201900229 10.1002/adma.201804982 10.1038/s41565-018-0221-0 10.1038/nature09522 10.1038/s41551-016-0010 10.1002/jbio.201500192 10.1039/C8SC04363A
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References	Fan (CR24) 2018; 13 Qi (CR39) 2018; 30 Lin (CR12) 2019; 10 Liu (CR49) 2018; 97 Huang (CR43) 2010; 30 Diao (CR19) 2015; 54 Zhang (CR52) 2018; 18 Hong, Antaris, Dai (CR5) 2017; 1 Ridker, Cook (CR1) 2013; 382 Armulik (CR51) 2010; 468 Qu (CR13) 2019; 7 Dang (CR23) 2016; 113 Furie, Furie (CR47) 2008; 359 Zhao (CR16) 2018; 30 Ding (CR10) 2018; 62 Antaris (CR33) 2017; 8 Pawley (CR40) 2006 Tsukasaki (CR4) 2014; 50 Wang, Li, Zhou, Zhang (CR25) 2014; 53 Choi (CR31) 2007; 25 Lei (CR34) 2019; 58 Sun (CR15) 2017; 8 Parker-Duffen (CR42) 2014; 289 Zhang (CR20) 2012; 6 Nordstrom, Olsson, Blomback (CR44) 1965; 206 Zhao, Li, Fan, Zhang (CR9) 2019; 8 Hong (CR3) 2012; 18 Lin (CR48) 2018; 15 Zhao (CR28) 2019; 58 Shi, Sordillo, Rodriguez-Contreras, Alfano (CR54) 2016; 9 Wang, Zhou, Wang, Li, Zhang (CR27) 2017; 8 Wang (CR8) 2018; 9 Zhang (CR26) 2019; 58 Wang (CR29) 2019; 10 Naczynski (CR22) 2013; 4 Sun (CR17) 2019; 141 Yang (CR30) 2008; 181 CR56 Guo (CR6) 2019; 31 Zeng (CR14) 2018; 7 Bruns (CR11) 2017; 1 Stein-Merlob (CR46) 2015; 5 Canhao (CR45) 2005; 36 Hong (CR18) 2014; 8 Zhu (CR36) 2018; 30 Bonnard, Hagemeyer (CR50) 2015; 100 Ma (CR21) 2018; 28 Li, Lu, Zhao, Lei, Zhang (CR32) 2018; 57 Pasterkamp, den Ruijter, Libby (CR2) 2017; 14 Wilson, Nadeau, Jaworski, Tromberg, Durkin (CR55) 2015; 20 Li, Pu (CR7) 2019; 48 Hynynen, McDannold, Vykhodtseva, Jolesz, Noninvasive (CR53) 2001; 220 Carr (CR37) 2018; 115 Starosolski (CR38) 2017; 12 Antaris (CR35) 2016; 15 Dickinson, Jimenez, Lawrence, Derubertis (CR41) 2010; 44 X Zeng (16924_CR14) 2018; 7 R Wang (16924_CR27) 2017; 8 NF Huang (16924_CR43) 2010; 30 H Zhang (16924_CR52) 2018; 18 J Li (16924_CR7) 2019; 48 C Qu (16924_CR13) 2019; 7 M Zhao (16924_CR28) 2019; 58 P Canhao (16924_CR45) 2005; 36 S-Y Liu (16924_CR49) 2018; 97 S Zhu (16924_CR36) 2018; 30 B Furie (16924_CR47) 2008; 359 J Lin (16924_CR12) 2019; 10 S Nordstrom (16924_CR44) 1965; 206 G Pasterkamp (16924_CR2) 2017; 14 B Ding (16924_CR10) 2018; 62 HS Choi (16924_CR31) 2007; 25 K Hynynen (16924_CR53) 2001; 220 AL Antaris (16924_CR35) 2016; 15 JL Parker-Duffen (16924_CR42) 2014; 289 B Guo (16924_CR6) 2019; 31 Y Zhang (16924_CR20) 2012; 6 Z Lei (16924_CR34) 2019; 58 JA Carr (16924_CR37) 2018; 115 BP Dickinson (16924_CR41) 2010; 44 S Diao (16924_CR19) 2015; 54 M Zhao (16924_CR16) 2018; 30 M Zhao (16924_CR9) 2019; 8 S Wang (16924_CR29) 2019; 10 L Shi (16924_CR54) 2016; 9 RH Wilson (16924_CR55) 2015; 20 A Armulik (16924_CR51) 2010; 468 Y Sun (16924_CR15) 2017; 8 OT Bruns (16924_CR11) 2017; 1 DJ Naczynski (16924_CR22) 2013; 4 G Hong (16924_CR3) 2012; 18 G Hong (16924_CR5) 2017; 1 P Wang (16924_CR8) 2018; 9 S-T Yang (16924_CR30) 2008; 181 Y Fan (16924_CR24) 2018; 13 Z Ma (16924_CR21) 2018; 28 C-H Lin (16924_CR48) 2018; 15 R Wang (16924_CR25) 2014; 53 Z Starosolski (16924_CR38) 2017; 12 16924_CR56 JB Pawley (16924_CR40) 2006 X Dang (16924_CR23) 2016; 113 AL Antaris (16924_CR33) 2017; 8 Y Tsukasaki (16924_CR4) 2014; 50 AF Stein-Merlob (16924_CR46) 2015; 5 H Zhang (16924_CR26) 2019; 58 B Li (16924_CR32) 2018; 57 C Sun (16924_CR17) 2019; 141 G Hong (16924_CR18) 2014; 8 PM Ridker (16924_CR1) 2013; 382 J Qi (16924_CR39) 2018; 30 T Bonnard (16924_CR50) 2015; 100
References_xml	– volume: 4 year: 2013 ident: CR22 article-title: Rare-earth-doped biological composites as in vivo shortwave infrared reporters publication-title: Nat. Commun. doi: 10.1038/ncomms3199 – volume: 382 start-page: 1762 year: 2013 end-page: 1765 ident: CR1 article-title: Statins: new American guidelines for prevention of cardiovascular disease publication-title: Lancet doi: 10.1016/S0140-6736(13)62388-0 – volume: 220 start-page: 640 year: 2001 end-page: 646 ident: CR53 article-title: imaging-guided focal opening of the blood-brain barrier in rabbits publication-title: Radiology doi: 10.1148/radiol.2202001804 – volume: 31 start-page: 1808355 year: 2019 ident: CR6 article-title: High-resolution 3D NIR-II photoacoustic imaging of cerebral and tumor vasculatures using conjugated polymer nanoparticles as contrast agent publication-title: Adv. Mater. doi: 10.1002/adma.201808355 – volume: 181 start-page: 182 year: 2008 end-page: 189 ident: CR30 article-title: Long-term accumulation and low toxicity of single-walled carbon nanotubes in intravenously exposed mice publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2008.07.020 – volume: 58 start-page: 2050 year: 2019 end-page: 2054 ident: CR28 article-title: Precise in vivo inflammation imaging using in situ responsive cross-linking of glutathione-modified ultra-small NIR-II lanthanide nanoparticles publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201812878 – volume: 12 start-page: e0187563 year: 2017 ident: CR38 article-title: Indocyanine green fluorescence in second near-infrared (NIR-II) window publication-title: PLoS ONE doi: 10.1371/journal.pone.0187563 – volume: 30 start-page: 1706856 year: 2018 ident: CR39 article-title: Real-time and high-resolution bioimaging with bright aggregation-induced emission dots in short-wave infrared region publication-title: Adv. Mater. doi: 10.1002/adma.201706856 – volume: 8 start-page: 1801650 year: 2019 ident: CR9 article-title: In vivo assembly and disassembly of probes to improve near-infrared optical bioimaging publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201801650 – volume: 62 start-page: 2049 year: 2018 end-page: 2059 ident: CR10 article-title: Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared subwindow publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.8b01682 – volume: 18 start-page: 1841 year: 2012 end-page: 1846 ident: CR3 article-title: Multifunctional in vivo vascular imaging using near-infrared II fluorescence publication-title: Nat. Med. doi: 10.1038/nm.2995 – volume: 1 start-page: 0056 year: 2017 ident: CR11 article-title: Next-generation in vivo optical imaging with short-wave infrared quantum dots publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-017-0056 – volume: 289 start-page: 16200 year: 2014 end-page: 16213 ident: CR42 article-title: Divergent roles for adiponectin receptor 1 (AdipoR1) and AdipoR2 in mediating revascularization and metabolic dysfunction in vivo publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.548115 – volume: 6 start-page: 3695 year: 2012 end-page: 3702 ident: CR20 article-title: Ag S quantum dot: a bright and biocompatible fluorescent nanoprobe in the second near-infrared window publication-title: ACS Nano doi: 10.1021/nn301218z – volume: 206 start-page: 632 year: 1965 end-page: 633 ident: CR44 article-title: Thromboplastin-induced hypercoagulability and its prevention publication-title: Nature doi: 10.1038/206632b0 – volume: 7 start-page: 1800589 year: 2018 ident: CR14 article-title: Near-infrared II dye-protein complex for biomedical imaging and imaging-guided photothermal therapy publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201800589 – volume: 359 start-page: 938 year: 2008 end-page: 949 ident: CR47 article-title: Mechanisms of thrombus formation publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0801082 – volume: 14 start-page: 21 year: 2017 end-page: 29 ident: CR2 article-title: Temporal shifts in clinical presentation and underlying mechanisms of atherosclerotic disease publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2016.166 – volume: 8 start-page: 3489 year: 2017 end-page: 3493 ident: CR15 article-title: Novel bright-emission small-molecule NIR-II fluorophores for in vivo tumor imaging and image-guided surgery publication-title: Chem. Sci. doi: 10.1039/C7SC00251C – volume: 8 year: 2017 ident: CR27 article-title: In vivo gastrointestinal drug-release monitoring through second near-infrared window fluorescent bioimaging with orally delivered microcarriers publication-title: Nat. Commun. doi: 10.1038/ncomms14702 – volume: 58 start-page: 8166 year: 2019 end-page: 8171 ident: CR34 article-title: Stable, wavelength-tunable fluorescent dyes in the NIR-II region for in vivo high-contrast bioimaging and multiplexed biosensing publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201904182 – volume: 58 start-page: 10153 year: 2019 end-page: 10157 ident: CR26 article-title: Tm -sensitized NIR-II fluorescent nanocrystals for in vivo information storage and decoding publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201903536 – volume: 57 start-page: 7483 year: 2018 end-page: 7487 ident: CR32 article-title: An efficient 1064 nm NIR-II excitation fluorescent molecular dye for deep-tissue high-resolution dynamic bioimaging publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201801226 – volume: 10 year: 2019 ident: CR29 article-title: Anti-quenching NIR-II molecular fluorophores for in vivo high-contrast imaging and pH sensing publication-title: Nat. Commun. doi: 10.1038/s41467-019-09043-x – volume: 36 start-page: 1720 year: 2005 end-page: 1725 ident: CR45 article-title: Causes and predictors of death in cerebral venous thrombosis publication-title: Stroke doi: 10.1161/01.STR.0000173152.84438.1c – volume: 15 start-page: 204 year: 2018 end-page: 210 ident: CR48 article-title: Recombinant tissue plasminogen activator in acute ischemic stroke patients receiving thrombectomy: standard or low dose therapy? publication-title: Curr. Neurovasc. Res. doi: 10.2174/1567202615666180717113526 – volume: 9 year: 2018 ident: CR8 article-title: NIR-II nanoprobes in-vivo assembly to improve image-guided surgery for metastatic ovarian cancer publication-title: Nat. Commun. doi: 10.1038/s41467-018-05113-8 – volume: 50 start-page: 14356 year: 2014 end-page: 14359 ident: CR4 article-title: A short-wavelength infrared emitting multimodal probe for non-invasive visualization of phagocyte cell migration in living mice publication-title: Chem. Commun. doi: 10.1039/C4CC06542E – volume: 15 start-page: 235 year: 2016 end-page: 242 ident: CR35 article-title: A small-molecule dye for NIR-II imaging publication-title: Nat. Mater. doi: 10.1038/nmat4476 – volume: 25 start-page: 1165 year: 2007 end-page: 1170 ident: CR31 article-title: Renal clearance of quantum dots publication-title: Nat. Biotechnol. doi: 10.1038/nbt1340 – volume: 97 start-page: e13216 year: 2018 ident: CR49 article-title: Effect of glycated hemoglobin index and mean arterial pressure on acute ischemic stroke prognosis after intravenous thrombolysis with recombinant tissue plasminogen activator publication-title: Medicine doi: 10.1097/MD.0000000000013216 – volume: 115 start-page: 4465 year: 2018 end-page: 4470 ident: CR37 article-title: Shortwave infrared fluorescence imaging with the clinically approved near-infrared dye indocyanine green publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1718917115 – volume: 113 start-page: 5179 year: 2016 end-page: 5184 ident: CR23 article-title: Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1521175113 – volume: 28 start-page: 1803417 year: 2018 ident: CR21 article-title: Near-infrared IIb fluorescence imaging of vascular regeneration with dynamic tissue perfusion measurement and high spatial resolution publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201803417 – volume: 18 start-page: 4985 year: 2018 end-page: 4992 ident: CR52 article-title: Monitoring the opening and recovery of the blood-brain barrier with noninvasive molecular imaging by biodegradable ultrasmall Cu Se nanoparticles publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b01818 – volume: 30 start-page: 984 year: 2010 end-page: 991 ident: CR43 article-title: Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion publication-title: Arterioscler Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.110.202796 – volume: 141 start-page: 19221 year: 2019 end-page: 19225 ident: CR17 article-title: J-Aggregates of cyanine dye for NIR-II in vivo dynamic vascular imaging beyond 1500 nm publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b10043 – year: 2006 ident: CR40 publication-title: Handbook of Biological Confocal Microscopy doi: 10.1007/978-0-387-45524-2 – volume: 54 start-page: 14758 year: 2015 end-page: 14762 ident: CR19 article-title: Fluorescence imaging in vivo at wavelengths beyond 1500 nm publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201507473 – volume: 20 start-page: 030901 year: 2015 ident: CR55 article-title: Review of short-wave infrared spectroscopy and imaging methods for biological tissue characterization publication-title: J. Biomed. Opt. doi: 10.1117/1.JBO.20.3.030901 – volume: 30 start-page: 1802546 year: 2018 ident: CR36 article-title: Repurposing cyanine NIR-I dyes accelerates clinical translation of near-infrared-II (NIR-II) bioimaging publication-title: Adv. Mater. doi: 10.1002/adma.201802546 – volume: 8 start-page: 723 year: 2014 end-page: 730 ident: CR18 article-title: Through-skull fluorescence imaging of the brain in a new near-infrared window publication-title: Nat. Photonics doi: 10.1038/nphoton.2014.166 – volume: 44 start-page: 315 year: 2010 end-page: 318 ident: CR41 article-title: Functional limb salvage following muscle rigor in a pediatric patient publication-title: Vasc. Endovasc. Surg. doi: 10.1177/1538574410363747 – volume: 5 start-page: 1317 year: 2015 end-page: 1327 ident: CR46 article-title: Blood accessibility to fibrin in venous thrombosis is thrombus age-dependent and predicts fibrinolytic efficacy: an in vivo fibrin molecular imaging study publication-title: Theranostics doi: 10.7150/thno.12494 – volume: 8 year: 2017 ident: CR33 article-title: A high quantum yield molecule-protein complex fluorophore for near-infrared II imaging publication-title: Nat. Commun. doi: 10.1038/ncomms15269 – ident: CR56 – volume: 48 start-page: 38 year: 2019 end-page: 71 ident: CR7 article-title: Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation publication-title: Chem. Soc. Rev. doi: 10.1039/C8CS00001H – volume: 53 start-page: 12086 year: 2014 end-page: 12090 ident: CR25 article-title: Epitaxial seeded growth of rare-earth nanocrystals with efficient 800 nm near-infrared to 1525 nm short-wavelength infrared downconversion photoluminescence for in vivo bioimaging publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201407420 – volume: 7 start-page: 1900229 year: 2019 ident: CR13 article-title: Quaternary ammonium salt based NIR-II probes for in vivo imaging publication-title: Adv. Optical Mater. doi: 10.1002/adom.201900229 – volume: 30 start-page: 1804982 year: 2018 ident: CR16 article-title: Supramolecularly engineered NIR-II and upconversion nanoparticles in vivo assembly and disassembly to improve bioimaging publication-title: Adv. Mater. doi: 10.1002/adma.201804982 – volume: 13 start-page: 941 year: 2018 end-page: 946 ident: CR24 article-title: Lifetime-engineered NIR-II nanoparticles unlock multiplexed in vivo imaging publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-018-0221-0 – volume: 100 start-page: 52838 year: 2015 ident: CR50 article-title: Ferric chloride-induced thrombosis mouse model on carotid artery and mesentery vessel publication-title: J. Vis. Exp. – volume: 468 start-page: 557 year: 2010 end-page: 561 ident: CR51 article-title: Pericytes regulate the blood-brain barrier publication-title: Nature doi: 10.1038/nature09522 – volume: 1 start-page: 0010 year: 2017 ident: CR5 article-title: Near-infrared fluorophores for biomedical imaging publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-016-0010 – volume: 9 start-page: 38 year: 2016 end-page: 43 ident: CR54 article-title: Transmission in near-infrared optical windows for deep brain imaging publication-title: J. Biophotonics doi: 10.1002/jbio.201500192 – volume: 10 start-page: 1219 year: 2019 end-page: 1226 ident: CR12 article-title: Novel near-infrared II aggregation-induced emission dots for in vivo bioimaging publication-title: Chem. Sci. doi: 10.1039/C8SC04363A – volume: 50 start-page: 14356 year: 2014 ident: 16924_CR4 publication-title: Chem. Commun. doi: 10.1039/C4CC06542E – volume: 53 start-page: 12086 year: 2014 ident: 16924_CR25 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201407420 – volume: 25 start-page: 1165 year: 2007 ident: 16924_CR31 publication-title: Nat. Biotechnol. doi: 10.1038/nbt1340 – volume: 30 start-page: 1802546 year: 2018 ident: 16924_CR36 publication-title: Adv. Mater. doi: 10.1002/adma.201802546 – volume: 12 start-page: e0187563 year: 2017 ident: 16924_CR38 publication-title: PLoS ONE doi: 10.1371/journal.pone.0187563 – ident: 16924_CR56 – volume: 15 start-page: 204 year: 2018 ident: 16924_CR48 publication-title: Curr. Neurovasc. Res. doi: 10.2174/1567202615666180717113526 – volume: 468 start-page: 557 year: 2010 ident: 16924_CR51 publication-title: Nature doi: 10.1038/nature09522 – volume: 181 start-page: 182 year: 2008 ident: 16924_CR30 publication-title: Toxicol. Lett. doi: 10.1016/j.toxlet.2008.07.020 – volume: 15 start-page: 235 year: 2016 ident: 16924_CR35 publication-title: Nat. Mater. doi: 10.1038/nmat4476 – volume: 20 start-page: 030901 year: 2015 ident: 16924_CR55 publication-title: J. Biomed. Opt. doi: 10.1117/1.JBO.20.3.030901 – volume: 7 start-page: 1800589 year: 2018 ident: 16924_CR14 publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201800589 – volume: 141 start-page: 19221 year: 2019 ident: 16924_CR17 publication-title: J. Am. Chem. Soc. doi: 10.1021/jacs.9b10043 – volume: 8 start-page: 3489 year: 2017 ident: 16924_CR15 publication-title: Chem. Sci. doi: 10.1039/C7SC00251C – volume: 7 start-page: 1900229 year: 2019 ident: 16924_CR13 publication-title: Adv. Optical Mater. doi: 10.1002/adom.201900229 – volume: 44 start-page: 315 year: 2010 ident: 16924_CR41 publication-title: Vasc. Endovasc. Surg. doi: 10.1177/1538574410363747 – volume: 13 start-page: 941 year: 2018 ident: 16924_CR24 publication-title: Nat. Nanotechnol. doi: 10.1038/s41565-018-0221-0 – volume: 382 start-page: 1762 year: 2013 ident: 16924_CR1 publication-title: Lancet doi: 10.1016/S0140-6736(13)62388-0 – volume: 58 start-page: 10153 year: 2019 ident: 16924_CR26 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201903536 – volume: 8 start-page: 723 year: 2014 ident: 16924_CR18 publication-title: Nat. Photonics doi: 10.1038/nphoton.2014.166 – volume: 100 start-page: 52838 year: 2015 ident: 16924_CR50 publication-title: J. Vis. Exp. – volume: 30 start-page: 1804982 year: 2018 ident: 16924_CR16 publication-title: Adv. Mater. doi: 10.1002/adma.201804982 – volume: 8 year: 2017 ident: 16924_CR33 publication-title: Nat. Commun. doi: 10.1038/ncomms15269 – volume: 10 year: 2019 ident: 16924_CR29 publication-title: Nat. Commun. doi: 10.1038/s41467-019-09043-x – volume: 1 start-page: 0010 year: 2017 ident: 16924_CR5 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-016-0010 – volume: 57 start-page: 7483 year: 2018 ident: 16924_CR32 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201801226 – volume: 14 start-page: 21 year: 2017 ident: 16924_CR2 publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2016.166 – volume: 30 start-page: 1706856 year: 2018 ident: 16924_CR39 publication-title: Adv. Mater. doi: 10.1002/adma.201706856 – volume: 6 start-page: 3695 year: 2012 ident: 16924_CR20 publication-title: ACS Nano doi: 10.1021/nn301218z – volume: 9 year: 2018 ident: 16924_CR8 publication-title: Nat. Commun. doi: 10.1038/s41467-018-05113-8 – volume: 30 start-page: 984 year: 2010 ident: 16924_CR43 publication-title: Arterioscler Thromb. Vasc. Biol. doi: 10.1161/ATVBAHA.110.202796 – volume: 8 start-page: 1801650 year: 2019 ident: 16924_CR9 publication-title: Adv. Healthc. Mater. doi: 10.1002/adhm.201801650 – volume: 359 start-page: 938 year: 2008 ident: 16924_CR47 publication-title: N. Engl. J. Med. doi: 10.1056/NEJMra0801082 – volume: 1 start-page: 0056 year: 2017 ident: 16924_CR11 publication-title: Nat. Biomed. Eng. doi: 10.1038/s41551-017-0056 – volume-title: Handbook of Biological Confocal Microscopy year: 2006 ident: 16924_CR40 doi: 10.1007/978-0-387-45524-2 – volume: 28 start-page: 1803417 year: 2018 ident: 16924_CR21 publication-title: Adv. Funct. Mater. doi: 10.1002/adfm.201803417 – volume: 36 start-page: 1720 year: 2005 ident: 16924_CR45 publication-title: Stroke doi: 10.1161/01.STR.0000173152.84438.1c – volume: 62 start-page: 2049 year: 2018 ident: 16924_CR10 publication-title: J. Med. Chem. doi: 10.1021/acs.jmedchem.8b01682 – volume: 9 start-page: 38 year: 2016 ident: 16924_CR54 publication-title: J. Biophotonics doi: 10.1002/jbio.201500192 – volume: 58 start-page: 2050 year: 2019 ident: 16924_CR28 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201812878 – volume: 113 start-page: 5179 year: 2016 ident: 16924_CR23 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1521175113 – volume: 48 start-page: 38 year: 2019 ident: 16924_CR7 publication-title: Chem. Soc. Rev. doi: 10.1039/C8CS00001H – volume: 31 start-page: 1808355 year: 2019 ident: 16924_CR6 publication-title: Adv. Mater. doi: 10.1002/adma.201808355 – volume: 220 start-page: 640 year: 2001 ident: 16924_CR53 publication-title: Radiology doi: 10.1148/radiol.2202001804 – volume: 206 start-page: 632 year: 1965 ident: 16924_CR44 publication-title: Nature doi: 10.1038/206632b0 – volume: 5 start-page: 1317 year: 2015 ident: 16924_CR46 publication-title: Theranostics doi: 10.7150/thno.12494 – volume: 10 start-page: 1219 year: 2019 ident: 16924_CR12 publication-title: Chem. Sci. doi: 10.1039/C8SC04363A – volume: 97 start-page: e13216 year: 2018 ident: 16924_CR49 publication-title: Medicine doi: 10.1097/MD.0000000000013216 – volume: 54 start-page: 14758 year: 2015 ident: 16924_CR19 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201507473 – volume: 4 year: 2013 ident: 16924_CR22 publication-title: Nat. Commun. doi: 10.1038/ncomms3199 – volume: 18 start-page: 4985 year: 2018 ident: 16924_CR52 publication-title: Nano Lett. doi: 10.1021/acs.nanolett.8b01818 – volume: 115 start-page: 4465 year: 2018 ident: 16924_CR37 publication-title: Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.1718917115 – volume: 289 start-page: 16200 year: 2014 ident: 16924_CR42 publication-title: J. Biol. Chem. doi: 10.1074/jbc.M114.548115 – volume: 8 year: 2017 ident: 16924_CR27 publication-title: Nat. Commun. doi: 10.1038/ncomms14702 – volume: 58 start-page: 8166 year: 2019 ident: 16924_CR34 publication-title: Angew. Chem. Int. Ed. doi: 10.1002/anie.201904182 – volume: 18 start-page: 1841 year: 2012 ident: 16924_CR3 publication-title: Nat. Med. doi: 10.1038/nm.2995
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Snippet	Real-time monitoring of vessel dysfunction is of great significance in preclinical research. Optical bioimaging in the second near-infrared (NIR-II) window... Optical bioimaging in the second near-infrared (NIR-II, 1000–1700 nm) window exhibits abundant advantages. Here the authors report an organic NIR-II molecule...
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SubjectTerms	59 639/638/11/874 639/638/11/942 692/699/75/593 Absorption Animals Blood circulation Blood vessels Blood-brain barrier Carotid Arteries - diagnostic imaging Carotid artery Contrast agents Emission analysis Emissions Female Fluorescent Dyes Half-life Hindlimb - diagnostic imaging Human Umbilical Vein Endothelial Cells Humanities and Social Sciences Humans I.R. radiation Ischemia Laboratories Lymphatic system Medical imaging Mice, Nude Monitoring multidisciplinary Near infrared radiation Neuroimaging Optical properties Pharmacokinetics Real time Reperfusion Reperfusion Injury - diagnostic imaging Science Science (multidisciplinary) Thrombolysis Thrombolytic drugs Thrombosis - diagnostic imaging Ultrasonic imaging Vascular Diseases - diagnostic imaging Veins & arteries Wavelength
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Title	Organic NIR-II molecule with long blood half-life for in vivo dynamic vascular imaging
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