Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery - Zhou, Tian; Zhu, Xinyi; Ye, Zhizhong; Wang, Yong-Fei; Yao, Chao; Xu, Ning; Zhou, Mi; Ma, Jianyang; Qin, Yuting; Shen, Yiwei; Tang, Yuanjia; Yin, Zhihua; et al. (Nature communications, 2022)
Keywords: 38/15; 49/39; 49/47; 49/91; 631/208/176/1988; 631/208/177; 631/208/200; 631/208/4041/3196; 692/4023/1670/1613; Autoimmune diseases; Autoimmune Diseases - genetics; Chromatin; CRISPR; DNA methylation; DNA Methylation - genetics; Gene expression; Gene loci; Genetic diversity; Genetic variance; Humanities and Social Sciences; Humans; Immune system; Interferon Regulatory Factors - genetics; Interferon Regulatory Factors - metabolism; Lupus; Mixed Function Oxygenases - metabolism; Molecular modelling; multidisciplinary; Proto-Oncogene Proteins - metabolism; PU.1 protein; Regulatory Sequences, Nucleic Acid; Risk; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Science; Science (multidisciplinary); Systemic lupus erythematosus; Transcription factors