Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery

Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, e...

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Published inNature communications Vol. 13; no. 1; pp. 1855 - 16
Main Authors Zhou, Tian, Zhu, Xinyi, Ye, Zhizhong, Wang, Yong-Fei, Yao, Chao, Xu, Ning, Zhou, Mi, Ma, Jianyang, Qin, Yuting, Shen, Yiwei, Tang, Yuanjia, Yin, Zhihua, Xu, Hong, Zhang, Yutong, Zang, Xiaoli, Ding, Huihua, Yang, Wanling, Guo, Ya, Harley, John B., Namjou, Bahram, Kaufman, Kenneth M., Kottyan, Leah C., Weirauch, Matthew T., Hou, Guojun, Shen, Nan
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 06.04.2022
Nature Publishing Group
Nature Portfolio
Subjects
38/15
49/39
49/47
49/91
631/208/176/1988
631/208/177
631/208/200
631/208/4041/3196
692/4023/1670/1613
Autoimmune diseases
Autoimmune Diseases - genetics
Chromatin
CRISPR
DNA methylation
DNA Methylation - genetics
Gene expression
Gene loci
Genetic diversity
Genetic variance
Humanities and Social Sciences
Humans
Immune system
Interferon Regulatory Factors - genetics
Interferon Regulatory Factors - metabolism
Lupus
Mixed Function Oxygenases - metabolism
Molecular modelling
multidisciplinary
Proto-Oncogene Proteins - metabolism
PU.1 protein
Regulatory Sequences, Nucleic Acid
Risk
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Science
Science (multidisciplinary)
Systemic lupus erythematosus
Transcription factors
Online AccessGet full text

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Abstract Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants. The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.
AbstractList Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants.Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants.
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants.
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants.
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants. The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.
Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing biological links between non-coding risk variants and the gene targets they regulate remains a considerable challenge. Here, we combine genetic, epigenomic, and CRISPR activation approaches to screen for functional variants that regulate IRF8 expression. We demonstrate that the locus containing rs2280381 is a cell-type-specific enhancer for IRF8 that spatially interacts with the IRF8 promoter. Further, rs2280381 mediates IRF8 expression through enhancer RNA AC092723.1, which recruits TET1 to the IRF8 promoter regulating IRF8 expression by affecting methylation levels. The alleles of rs2280381 modulate PU.1 binding and chromatin state to regulate AC092723.1 and IRF8 expression differentially. Our work illustrates an integrative strategy to define functional genetic variants that regulate the expression of critical genes in autoimmune diseases and decipher the mechanisms underlying the dysregulation of IRF8 expression mediated by lupus risk variants.The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the authors define an immune cell-type-specific enhancer and the molecular mechanisms underlying the dysregulation of IRF8 expression by lupus risk variants.
ArticleNumber 1855
Author Weirauch, Matthew T.
Zhou, Mi
Yao, Chao
Zhang, Yutong
Guo, Ya
Zhou, Tian
Namjou, Bahram
Shen, Yiwei
Kottyan, Leah C.
Shen, Nan
Hou, Guojun
Yang, Wanling
Ma, Jianyang
Harley, John B.
Ding, Huihua
Yin, Zhihua
Xu, Hong
Zhu, Xinyi
Ye, Zhizhong
Qin, Yuting
Xu, Ning
Kaufman, Kenneth M.
Tang, Yuanjia
Wang, Yong-Fei
Zang, Xiaoli
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/35388006$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1186/s12920-018-0468-1
10.1038/ng.2462
10.1038/ng.3786
10.1038/s41588-019-0538-0
10.1101/gr.216747.116
10.1093/nar/gkz020
10.1038/ng.2871
10.1073/pnas.1222798110
10.1172/JCI120288
10.1186/1471-2105-12-489
10.4049/jimmunol.1202341
10.1126/science.1192002
10.1038/s41467-020-20460-1
10.1038/s41580-020-00315-9
10.1038/s41588-019-0457-0
10.1038/ng.401
10.1101/gr.265249.120
10.1016/j.cell.2021.02.015
10.1016/j.cell.2021.03.056
10.1016/j.jaut.2019.102315
10.1038/s41467-019-10652-9
10.1073/pnas.1017214108
10.2741/3001
10.1016/j.molmed.2020.01.004
10.1038/ng.2770
10.1172/JCI125116
10.1016/j.cell.2017.06.049
10.1111/iji.12087
10.1038/nri.2017.52
10.1038/s41467-021-21854-5
10.1007/s00439-020-02154-2
10.1182/blood-2014-04-570879
10.1126/science.aaz1776
10.1016/j.immuni.2012.03.014
10.1074/jbc.M115.705467
10.1186/s13075-015-0602-9
10.4049/jimmunol.1301169
10.1056/NEJMoa2031054
10.1126/science.1165409
10.1016/j.tcb.2015.07.002
10.1038/s41590-021-00871-y
10.1038/s41586-021-03446-x
10.1016/j.cell.2018.01.029
10.1186/gb-2011-12-8-r83
10.1038/s41467-021-21049-y
10.1016/j.cell.2018.11.029
10.1038/gene.2013.42
10.1038/s41588-018-0102-3
10.1038/ng.3434
10.1126/science.aag2445
10.1038/s41467-021-23007-0
10.4172/jcsb.1000115
10.1016/j.cell.2018.03.016
10.1038/s41586-019-1711-4
10.1038/nmeth.3630
10.1002/art.40476
10.1371/journal.pgen.1002341
10.1038/s41576-020-00287-8
10.1038/s41588-018-0089-9
10.1371/journal.pgen.1002178
10.1016/j.cell.2016.09.005
10.1136/annrheumdis-2017-212794
10.1371/journal.pgen.1002097
10.1038/s41588-018-0046-7
10.1038/ng983
10.1016/j.cell.2011.01.024
10.1016/j.jneuroim.2015.03.015
10.1084/jem.20190185
10.1073/pnas.1005599107
10.1038/nature13835
10.1038/nature14136
10.1038/s41467-019-12760-y
10.1016/j.ajhg.2012.02.023
10.1038/nature23875
10.1136/annrheumdis-2020-219065
10.7554/eLife.65381
10.1038/s41568-019-0196-7
10.1210/clinem/dgz239
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References Frangoul (CR11) 2021; 384
Parry, Rulands, Reik (CR53) 2021; 22
Chrabot (CR26) 2013; 14
Bushweller (CR4) 2019; 19
Liu (CR44) 2011; 12
Gorlova (CR36) 2011; 7
CR35
Konermann (CR41) 2015; 517
Liu (CR10) 2018; 173
Oleksiak, Churchill, Crawford (CR6) 2002; 32
Takeuchi (CR30) 2017; 49
Bashinskaya (CR39) 2015; 282
Hughes (CR67) 2014; 46
Gupta (CR21) 2017; 170
Mohammadi, Castel, Brown, Lappalainen (CR8) 2017; 27
Petri (CR79) 2019; 12
Sun (CR18) 2017; 17
Savitsky, Yanai, Tamura, Taniguchi, Honda (CR2) 2010; 107
Salem, Salem, Gros (CR31) 2020; 139
Li, He, Zheng, Liu, Liu (CR27) 2014; 41
Pathak, Ma, Shukla, Lu (CR72) 2013; 191
Fulco (CR42) 2016; 354
Sjöstrand (CR33) 2013; 191
Hu (CR81) 2018; 70
Song (CR3) 2020; 130
Lambert (CR1) 2018; 172
Muppirala, Honavar, Dobbs (CR51) 2011; 12
Shin (CR64) 2018; 41
Karagianni, Tzioufas (CR13) 2019; 104
Muppirala, Lewis, Dobbs (CR52) 2013; 6
Farh (CR14) 2015; 518
Schmiedel (CR20) 2018; 175
Yu (CR50) 2021; 184
Gasperini (CR62) 2019; 176
Lu (CR78) 2021; 12
van der Wijst (CR19) 2018; 50
White, Kessler, Dickerman, Ozato, Sen (CR32) 2016; 291
Hou (CR66) 2021; 12
Chu, Quinn, Chang (CR48) 2012; 61
Panwar (CR82) 2021; 31
Chatterjee (CR75) 2016; 167
Kuriakose (CR74) 2019; 129
Jin, Li, Ren, Natarajan (CR56) 2011; 108
Wang (CR16) 2021; 12
CR15
Thakore (CR63) 2015; 12
Böhmdorfer, Wierzbicki (CR77) 2015; 25
Fulco (CR61) 2019; 51
Ota (CR70) 2021; 184
Statello, Guo, Chen, Huarte (CR76) 2021; 22
Chen, Koehler (CR5) 2020; 26
De Jager (CR23) 2009; 41
Bentham (CR38) 2015; 47
Peng (CR58) 2008; 13
Salem (CR46) 2014; 124
Sheng (CR28) 2015; 17
Alasoo (CR22) 2018; 50
Miguel-Escalada (CR59) 2019; 51
O’Shea, Plenge (CR17) 2012; 36
Hagberg (CR9) 2018; 77
Mohaghegh (CR45) 2019; 47
Tsai (CR49) 2010; 329
Consortium (CR7) 2020; 369
Cunninghame Graham (CR24) 2011; 7
Eyre (CR34) 2012; 44
Nasser (CR43) 2021; 593
CR29
Beecham (CR40) 2013; 45
Bell (CR65) 2019; 10
Marquis (CR47) 2011; 7
Abramov (CR57) 2021; 12
Simeonov (CR60) 2017; 549
CR68
Murakami (CR73) 2021; 22
López-Isac (CR37) 2019; 10
Harley (CR55) 2018; 50
Baccala (CR71) 2013; 110
Lessard, Christopher (CR25) 2012; 90
Bulger, Groudine (CR69) 2011; 144
Sankaran (CR12) 2008; 322
Anzalone (CR54) 2019; 576
Hong (CR80) 2019; 216
P Mohammadi (29514_CR8) 2017; 27
B Panwar (29514_CR82) 2021; 31
F Jin (29514_CR56) 2011; 108
VG Sankaran (29514_CR12) 2008; 322
RM Gupta (29514_CR21) 2017; 170
T Liu (29514_CR44) 2011; 12
X Lu (29514_CR78) 2021; 12
S Hong (29514_CR80) 2019; 216
M Sjöstrand (29514_CR33) 2013; 191
JJ O’Shea (29514_CR17) 2012; 36
DA Savitsky (29514_CR2) 2010; 107
H Frangoul (29514_CR11) 2021; 384
K Alasoo (29514_CR22) 2018; 50
MGP van der Wijst (29514_CR19) 2018; 50
S Eyre (29514_CR34) 2012; 44
AH Beecham (29514_CR40) 2013; 45
S Salem (29514_CR31) 2020; 139
R Baccala (29514_CR71) 2013; 110
KK-H Farh (29514_CR14) 2015; 518
N Mohaghegh (29514_CR45) 2019; 47
PI Thakore (29514_CR63) 2015; 12
A Chen (29514_CR5) 2020; 26
M Bulger (29514_CR69) 2011; 144
DR Simeonov (29514_CR60) 2017; 549
SL Peng (29514_CR58) 2008; 13
J Lessard, Christopher (29514_CR25) 2012; 90
JR Hughes (29514_CR67) 2014; 46
BS Chrabot (29514_CR26) 2013; 14
UK Muppirala (29514_CR52) 2013; 6
M Gasperini (29514_CR62) 2019; 176
29514_CR68
JB Harley (29514_CR55) 2018; 50
J Bentham (29514_CR38) 2015; 47
VV Bashinskaya (29514_CR39) 2015; 282
AV Anzalone (29514_CR54) 2019; 576
DS Cunninghame Graham (29514_CR24) 2011; 7
JF Marquis (29514_CR47) 2011; 7
YJ Sheng (29514_CR28) 2015; 17
M Petri (29514_CR79) 2019; 12
MC Tsai (29514_CR49) 2010; 329
UK Muppirala (29514_CR51) 2011; 12
S Konermann (29514_CR41) 2015; 517
G Consortium (29514_CR7) 2020; 369
G Böhmdorfer (29514_CR77) 2015; 25
P Karagianni (29514_CR13) 2019; 104
A Parry (29514_CR53) 2021; 22
MF Oleksiak (29514_CR6) 2002; 32
29514_CR15
K Murakami (29514_CR73) 2021; 22
SA Lambert (29514_CR1) 2018; 172
BJ Schmiedel (29514_CR20) 2018; 175
N Liu (29514_CR10) 2018; 173
29514_CR35
G Hou (29514_CR66) 2021; 12
O Gorlova (29514_CR36) 2011; 7
CC Bell (29514_CR65) 2019; 10
J Nasser (29514_CR43) 2021; 593
S Song (29514_CR3) 2020; 130
SW Li (29514_CR27) 2014; 41
YF Wang (29514_CR16) 2021; 12
M Ota (29514_CR70) 2021; 184
M Takeuchi (29514_CR30) 2017; 49
29514_CR29
CP Fulco (29514_CR42) 2016; 354
C Chu (29514_CR48) 2012; 61
S Abramov (29514_CR57) 2021; 12
Y Hu (29514_CR81) 2018; 70
SC Sun (29514_CR18) 2017; 17
L Statello (29514_CR76) 2021; 22
N Hagberg (29514_CR9) 2018; 77
B Yu (29514_CR50) 2021; 184
S Chatterjee (29514_CR75) 2016; 167
CP Fulco (29514_CR61) 2019; 51
S Pathak (29514_CR72) 2013; 191
S Salem (29514_CR46) 2014; 124
HY Shin (29514_CR64) 2018; 41
JH Bushweller (29514_CR4) 2019; 19
CL White (29514_CR32) 2016; 291
E López-Isac (29514_CR37) 2019; 10
I Miguel-Escalada (29514_CR59) 2019; 51
J Kuriakose (29514_CR74) 2019; 129
PL De Jager (29514_CR23) 2009; 41
35538211 - Nat Rev Rheumatol. 2022 Jun;18(6):306
References_xml – volume: 12
  year: 2019
  ident: CR79
  article-title: Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus
  publication-title: BMC Med Genomics
  doi: 10.1186/s12920-018-0468-1
– volume: 44
  start-page: 1336
  year: 2012
  end-page: 1340
  ident: CR34
  article-title: High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2462
– volume: 49
  start-page: 438
  year: 2017
  end-page: 443
  ident: CR30
  article-title: Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet’s disease susceptibility
  publication-title: Nat. Genet
  doi: 10.1038/ng.3786
– ident: CR68
– volume: 51
  start-page: 1664
  year: 2019
  end-page: 1669
  ident: CR61
  article-title: Activity-by-contact model of enhancer–promoter regulation from thousands of CRISPR perturbations
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0538-0
– volume: 27
  start-page: 1872
  year: 2017
  end-page: 1884
  ident: CR8
  article-title: Quantifying the regulatory effect size of cis-acting genetic variation using allelic fold change
  publication-title: Genome Res.
  doi: 10.1101/gr.216747.116
– volume: 47
  start-page: e31
  year: 2019
  ident: CR45
  article-title: NextPBM: a platform to study cell-specific transcription factor binding and cooperativity
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz020
– volume: 46
  start-page: 205
  year: 2014
  end-page: 212
  ident: CR67
  article-title: Analysis of hundreds of cis-regulatory landscapes at high resolution in a single, high-throughput experiment
  publication-title: Nat. Genet
  doi: 10.1038/ng.2871
– volume: 110
  start-page: 2940
  year: 2013
  end-page: 2945
  ident: CR71
  article-title: Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1222798110
– volume: 130
  start-page: 6700
  year: 2020
  end-page: 6717
  ident: CR3
  article-title: Inhibition of IRF5 hyperactivation protects from lupus onset and severity
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI120288
– volume: 12
  year: 2011
  ident: CR51
  article-title: Predicting RNA-protein interactions using only sequence information
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-12-489
– volume: 191
  start-page: 3753
  year: 2013
  end-page: 3763
  ident: CR33
  article-title: Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1202341
– volume: 329
  start-page: 689
  year: 2010
  end-page: 693
  ident: CR49
  article-title: Long noncoding RNA as modular scaffold of histone modification complexes
  publication-title: Science
  doi: 10.1126/science.1192002
– volume: 12
  year: 2021
  ident: CR66
  article-title: SLE non-coding genetic risk variant determines the epigenetic dysfunction of an immune cell specific enhancer that controls disease-critical microRNA expression
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-20460-1
– ident: CR35
– ident: CR29
– volume: 22
  start-page: 96
  year: 2021
  end-page: 118
  ident: CR76
  article-title: Gene regulation by long non-coding RNAs and its biological functions
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-00315-9
– volume: 51
  start-page: 1137
  year: 2019
  end-page: 1148
  ident: CR59
  article-title: Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0457-0
– volume: 41
  start-page: 506
  year: 2018
  end-page: 514
  ident: CR64
  article-title: Targeting super-enhancers for disease treatment and diagnosis
  publication-title: Mol. Cells
– volume: 41
  start-page: 776
  year: 2009
  end-page: 782
  ident: CR23
  article-title: Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci
  publication-title: Nat. Genet.
  doi: 10.1038/ng.401
– volume: 31
  start-page: 659
  year: 2021
  end-page: 676
  ident: CR82
  article-title: Multi-cell type gene coexpression network analysis reveals coordinated interferon response and cross-cell type correlations in systemic lupus erythematosus
  publication-title: Genome Res.
  doi: 10.1101/gr.265249.120
– volume: 61
  year: 2012
  ident: CR48
  article-title: Chromatin isolation by RNA purification (ChIRP)
  publication-title: J. Vis. Exp.
– volume: 184
  start-page: 1790
  year: 2021
  end-page: 1803.e17
  ident: CR50
  article-title: B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells
  publication-title: Cell
  doi: 10.1016/j.cell.2021.02.015
– volume: 184
  start-page: 3006
  year: 2021
  end-page: 3021.e17
  ident: CR70
  article-title: Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.056
– volume: 104
  start-page: 102315
  year: 2019
  ident: CR13
  article-title: Epigenetic perspectives on systemic autoimmune disease
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2019.102315
– volume: 10
  year: 2019
  ident: CR65
  article-title: Targeting enhancer switching overcomes non-genetic drug resistance in acute myeloid leukaemia
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10652-9
– volume: 108
  start-page: 5290
  year: 2011
  end-page: 5295
  ident: CR56
  article-title: PU.1 and C/EBPα synergistically program distinct response to NF-κB activation through establishing monocyte specific enhancers
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1017214108
– volume: 13
  start-page: 4218
  year: 2008
  end-page: 4240
  ident: CR58
  article-title: Transcription factors in autoimmune diseases
  publication-title: Front. Biosci.
  doi: 10.2741/3001
– volume: 26
  start-page: 508
  year: 2020
  end-page: 518
  ident: CR5
  article-title: Transcription factor inhibition: lessons learned and emerging targets
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2020.01.004
– volume: 45
  start-page: 1353
  year: 2013
  end-page: 1360
  ident: CR40
  article-title: Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2770
– ident: CR15
– volume: 129
  start-page: 2251
  year: 2019
  end-page: 2265
  ident: CR74
  article-title: Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI125116
– volume: 170
  start-page: 522
  year: 2017
  end-page: 533.e15
  ident: CR21
  article-title: A genetic variant associated with five vascular diseases is a distal regulator of endothelin-1 gene expression
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.049
– volume: 41
  start-page: 112
  year: 2014
  end-page: 118
  ident: CR27
  article-title: Single-nucleotide polymorphisms of IRF8 gene are associated with systemic lupus erythematosus in Chinese Han population
  publication-title: Int J. Immunogenet.
  doi: 10.1111/iji.12087
– volume: 17
  start-page: 545
  year: 2017
  end-page: 558
  ident: CR18
  article-title: The non-canonical NF-κB pathway in immunity and inflammation
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.52
– volume: 12
  year: 2021
  ident: CR78
  article-title: Global discovery of lupus genetic risk variant allelic enhancer activity
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21854-5
– volume: 139
  start-page: 707
  year: 2020
  end-page: 721
  ident: CR31
  article-title: Role of IRF8 in immune cells functions, protection against infections, and susceptibility to inflammatory diseases
  publication-title: Hum. Genet
  doi: 10.1007/s00439-020-02154-2
– volume: 124
  start-page: 1894
  year: 2014
  end-page: 1904
  ident: CR46
  article-title: Functional characterization of the human dendritic cell immunodeficiency associated with the IRF8(K108E) mutation
  publication-title: Blood
  doi: 10.1182/blood-2014-04-570879
– volume: 369
  start-page: 1318
  year: 2020
  end-page: 1330
  ident: CR7
  article-title: The GTEx Consortium atlas of genetic regulatory effects across human tissues
  publication-title: Science
  doi: 10.1126/science.aaz1776
– volume: 36
  start-page: 542
  year: 2012
  end-page: 550
  ident: CR17
  article-title: JAK and STAT signaling molecules in immunoregulation and immune-mediated disease
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.03.014
– volume: 291
  start-page: 13535
  year: 2016
  end-page: 13545
  ident: CR32
  article-title: Interferon regulatory factor 8 (IRF8) impairs induction of interferon induced with tetratricopeptide repeat motif (IFIT) gene family members
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.705467
– volume: 17
  start-page: 85
  year: 2015
  ident: CR28
  article-title: Association analyses confirm five susceptibility loci for systemic lupus erythematosus in the Han Chinese population
  publication-title: Arthritis Res Ther.
  doi: 10.1186/s13075-015-0602-9
– volume: 191
  start-page: 6222
  year: 2013
  end-page: 6230
  ident: CR72
  article-title: A role for IRF8 in B cell anergy
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1301169
– volume: 384
  start-page: 252
  year: 2021
  end-page: 260
  ident: CR11
  article-title: CRISPR-Cas9 gene editing for sickle cell disease and β-thalassemia
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031054
– volume: 322
  start-page: 1839
  year: 2008
  end-page: 1842
  ident: CR12
  article-title: Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A
  publication-title: Science
  doi: 10.1126/science.1165409
– volume: 25
  start-page: 623
  year: 2015
  end-page: 632
  ident: CR77
  article-title: Control of chromatin structure by long noncoding RNA
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2015.07.002
– volume: 175
  start-page: 1701
  year: 2018
  end-page: 1715.e16
  ident: CR20
  article-title: Impact of genetic polymorphisms on human immune
  publication-title: Cell Gene Expr. Cell
– volume: 22
  start-page: 301
  year: 2021
  end-page: 311
  ident: CR73
  article-title: A RUNX-CBFβ-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-00871-y
– volume: 593
  start-page: 238
  year: 2021
  end-page: 243
  ident: CR43
  article-title: Genome-wide enhancer maps link risk variants to disease genes
  publication-title: Nature
  doi: 10.1038/s41586-021-03446-x
– volume: 172
  start-page: 650
  year: 2018
  end-page: 665
  ident: CR1
  article-title: The human transcription factors
  publication-title: Cell
  doi: 10.1016/j.cell.2018.01.029
– volume: 12
  year: 2011
  ident: CR44
  article-title: Cistrome: an integrative platform for transcriptional regulation studies
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-8-r83
– volume: 12
  year: 2021
  ident: CR16
  article-title: Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21049-y
– volume: 176
  start-page: 377
  year: 2019
  end-page: 390.e19
  ident: CR62
  article-title: A genome-wide framework for mapping gene regulation via cellular genetic screens
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.029
– volume: 14
  start-page: 471
  year: 2013
  end-page: 478
  ident: CR26
  article-title: Genetic variation near IRF8 is associated with serologic and cytokine profiles in systemic lupus erythematosus and multiple sclerosis
  publication-title: Genes Immun.
  doi: 10.1038/gene.2013.42
– volume: 50
  start-page: 699
  year: 2018
  end-page: 707
  ident: CR55
  article-title: Transcription factors operate across disease loci, with EBNA2 implicated in autoimmunity
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0102-3
– volume: 47
  start-page: 1457
  year: 2015
  end-page: 1464
  ident: CR38
  article-title: Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3434
– volume: 354
  start-page: 769
  year: 2016
  end-page: 773
  ident: CR42
  article-title: Systematic mapping of functional enhancer-promoter connections with CRISPR interference
  publication-title: Science
  doi: 10.1126/science.aag2445
– volume: 12
  year: 2021
  ident: CR57
  article-title: Landscape of allele-specific transcription factor binding in the human genome
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-23007-0
– volume: 6
  start-page: 182
  year: 2013
  end-page: 187
  ident: CR52
  article-title: Computational tools for investigating RNA-protein interaction partners
  publication-title: J. Comput. Sci. Syst. Biol.
  doi: 10.4172/jcsb.1000115
– volume: 173
  start-page: 430
  year: 2018
  end-page: 442.e17
  ident: CR10
  article-title: Direct promoter repression by BCL11A controls the fetal to adult hemoglobin switch
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.016
– volume: 576
  start-page: 149
  year: 2019
  end-page: 157
  ident: CR54
  article-title: Search-and-replace genome editing without double-strand breaks or donor DNA
  publication-title: Nature
  doi: 10.1038/s41586-019-1711-4
– volume: 12
  start-page: 1143
  year: 2015
  end-page: 1149
  ident: CR63
  article-title: Highly specific epigenome editing by CRISPR-Cas9 repressors for silencing of distal regulatory elements
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3630
– volume: 70
  start-page: 1331
  year: 2018
  end-page: 1342
  ident: CR81
  article-title: Development of a molecular signature to monitor pharmacodynamic responses mediated by in vivo administration of glucocorticoids
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.40476
– volume: 7
  start-page: e1002341
  year: 2011
  ident: CR24
  article-title: Association of NCF2, IKZF1, IRF8, IFIH1, and TYK2 with systemic lupus erythematosus
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002341
– volume: 22
  start-page: 59
  year: 2021
  end-page: 66
  ident: CR53
  article-title: Active turnover of DNA methylation during cell fate decisions
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-020-00287-8
– volume: 50
  start-page: 493
  year: 2018
  end-page: 497
  ident: CR19
  article-title: Single-cell RNA sequencing identifies celltype-specific cis-eQTLs and co-expression QTLs
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0089-9
– volume: 7
  start-page: e1002178
  year: 2011
  ident: CR36
  article-title: Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002178
– volume: 167
  start-page: 355
  year: 2016
  end-page: 368.e10
  ident: CR75
  article-title: Enhancer variants synergistically drive dysfunction of a gene regulatory network in hirschsprung disease
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.005
– volume: 77
  start-page: 1070
  year: 2018
  end-page: 1077
  ident: CR9
  article-title: The STAT4 SLE risk allele rs7574865[T] is associated with increased IL-12-induced IFN-γ production in T cells from patients with SLE
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2017-212794
– volume: 7
  start-page: e1002097
  year: 2011
  ident: CR47
  article-title: Interferon regulatory factor 8 regulates pathways for antigen presentation in myeloid cells and during tuberculosis
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002097
– volume: 50
  start-page: 424
  year: 2018
  end-page: 431
  ident: CR22
  article-title: Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0046-7
– volume: 32
  start-page: 261
  year: 2002
  end-page: 266
  ident: CR6
  article-title: Variation in gene expression within and among natural populations
  publication-title: Nat. Genet.
  doi: 10.1038/ng983
– volume: 144
  start-page: 327
  year: 2011
  end-page: 339
  ident: CR69
  article-title: Functional and mechanistic diversity of distal transcription enhancers
  publication-title: Cell
  doi: 10.1016/j.cell.2011.01.024
– volume: 282
  start-page: 85
  year: 2015
  end-page: 91
  ident: CR39
  article-title: GWAS-identified multiple sclerosis risk loci involved in immune response: validation in Russians
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2015.03.015
– volume: 19
  start-page: 611
  year: 2019
  end-page: 624
  ident: CR4
  article-title: Targeting transcription factors in cancer—from undruggable to reality
  publication-title: Nat. Rev. Cancer
– volume: 216
  start-page: 1154
  year: 2019
  end-page: 1169
  ident: CR80
  article-title: Longitudinal profiling of human blood transcriptome in healthy and lupus pregnancy
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20190185
– volume: 107
  start-page: 10154
  year: 2010
  end-page: 10159
  ident: CR2
  article-title: Contribution of IRF5 in B cells to the development of murine SLE-like disease through its transcriptional control of the IgG2a locus
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1005599107
– volume: 518
  start-page: 337
  year: 2015
  end-page: 343
  ident: CR14
  article-title: Genetic and epigenetic fine mapping of causal autoimmune disease variants
  publication-title: Nature
  doi: 10.1038/nature13835
– volume: 517
  start-page: 583
  year: 2015
  end-page: 588
  ident: CR41
  article-title: Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
  publication-title: Nature
  doi: 10.1038/nature14136
– volume: 10
  year: 2019
  ident: CR37
  article-title: GWAS for systemic sclerosis identifies multiple risk loci and highlights fibrotic and vasculopathy pathways
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12760-y
– volume: 90
  start-page: 648
  year: 2012
  end-page: 660
  ident: CR25
  article-title: Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2012.02.023
– volume: 549
  start-page: 111
  year: 2017
  end-page: 115
  ident: CR60
  article-title: Discovery of stimulation-responsive immune enhancers with CRISPR activation
  publication-title: Nature
  doi: 10.1038/nature23875
– volume: 107
  start-page: 10154
  year: 2010
  ident: 29514_CR2
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1005599107
– volume: 384
  start-page: 252
  year: 2021
  ident: 29514_CR11
  publication-title: N. Engl. J. Med.
  doi: 10.1056/NEJMoa2031054
– volume: 322
  start-page: 1839
  year: 2008
  ident: 29514_CR12
  publication-title: Science
  doi: 10.1126/science.1165409
– volume: 12
  start-page: 1143
  year: 2015
  ident: 29514_CR63
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3630
– volume: 50
  start-page: 424
  year: 2018
  ident: 29514_CR22
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0046-7
– volume: 170
  start-page: 522
  year: 2017
  ident: 29514_CR21
  publication-title: Cell
  doi: 10.1016/j.cell.2017.06.049
– volume: 12
  year: 2021
  ident: 29514_CR57
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-23007-0
– volume: 45
  start-page: 1353
  year: 2013
  ident: 29514_CR40
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2770
– volume: 176
  start-page: 377
  year: 2019
  ident: 29514_CR62
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.029
– volume: 184
  start-page: 1790
  year: 2021
  ident: 29514_CR50
  publication-title: Cell
  doi: 10.1016/j.cell.2021.02.015
– ident: 29514_CR35
  doi: 10.1136/annrheumdis-2020-219065
– volume: 25
  start-page: 623
  year: 2015
  ident: 29514_CR77
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2015.07.002
– volume: 51
  start-page: 1664
  year: 2019
  ident: 29514_CR61
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0538-0
– volume: 31
  start-page: 659
  year: 2021
  ident: 29514_CR82
  publication-title: Genome Res.
  doi: 10.1101/gr.265249.120
– volume: 139
  start-page: 707
  year: 2020
  ident: 29514_CR31
  publication-title: Hum. Genet
  doi: 10.1007/s00439-020-02154-2
– volume: 191
  start-page: 6222
  year: 2013
  ident: 29514_CR72
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1301169
– volume: 12
  year: 2011
  ident: 29514_CR51
  publication-title: BMC Bioinforma.
  doi: 10.1186/1471-2105-12-489
– volume: 32
  start-page: 261
  year: 2002
  ident: 29514_CR6
  publication-title: Nat. Genet.
  doi: 10.1038/ng983
– volume: 7
  start-page: e1002341
  year: 2011
  ident: 29514_CR24
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002341
– volume: 26
  start-page: 508
  year: 2020
  ident: 29514_CR5
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2020.01.004
– volume: 49
  start-page: 438
  year: 2017
  ident: 29514_CR30
  publication-title: Nat. Genet
  doi: 10.1038/ng.3786
– volume: 130
  start-page: 6700
  year: 2020
  ident: 29514_CR3
  publication-title: J. Clin. Invest
  doi: 10.1172/JCI120288
– volume: 41
  start-page: 112
  year: 2014
  ident: 29514_CR27
  publication-title: Int J. Immunogenet.
  doi: 10.1111/iji.12087
– volume: 184
  start-page: 3006
  year: 2021
  ident: 29514_CR70
  publication-title: Cell
  doi: 10.1016/j.cell.2021.03.056
– volume: 22
  start-page: 96
  year: 2021
  ident: 29514_CR76
  publication-title: Nat. Rev. Mol. Cell Biol.
  doi: 10.1038/s41580-020-00315-9
– volume: 12
  year: 2021
  ident: 29514_CR78
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21854-5
– volume: 61
  year: 2012
  ident: 29514_CR48
  publication-title: J. Vis. Exp.
– volume: 10
  year: 2019
  ident: 29514_CR65
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-10652-9
– volume: 12
  year: 2021
  ident: 29514_CR66
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-020-20460-1
– ident: 29514_CR68
  doi: 10.7554/eLife.65381
– volume: 576
  start-page: 149
  year: 2019
  ident: 29514_CR54
  publication-title: Nature
  doi: 10.1038/s41586-019-1711-4
– volume: 593
  start-page: 238
  year: 2021
  ident: 29514_CR43
  publication-title: Nature
  doi: 10.1038/s41586-021-03446-x
– volume: 549
  start-page: 111
  year: 2017
  ident: 29514_CR60
  publication-title: Nature
  doi: 10.1038/nature23875
– volume: 19
  start-page: 611
  year: 2019
  ident: 29514_CR4
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/s41568-019-0196-7
– volume: 70
  start-page: 1331
  year: 2018
  ident: 29514_CR81
  publication-title: Arthritis Rheumatol.
  doi: 10.1002/art.40476
– ident: 29514_CR15
– volume: 12
  year: 2019
  ident: 29514_CR79
  publication-title: BMC Med Genomics
  doi: 10.1186/s12920-018-0468-1
– volume: 167
  start-page: 355
  year: 2016
  ident: 29514_CR75
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.005
– volume: 172
  start-page: 650
  year: 2018
  ident: 29514_CR1
  publication-title: Cell
  doi: 10.1016/j.cell.2018.01.029
– volume: 124
  start-page: 1894
  year: 2014
  ident: 29514_CR46
  publication-title: Blood
  doi: 10.1182/blood-2014-04-570879
– volume: 36
  start-page: 542
  year: 2012
  ident: 29514_CR17
  publication-title: Immunity
  doi: 10.1016/j.immuni.2012.03.014
– volume: 369
  start-page: 1318
  year: 2020
  ident: 29514_CR7
  publication-title: Science
  doi: 10.1126/science.aaz1776
– volume: 41
  start-page: 776
  year: 2009
  ident: 29514_CR23
  publication-title: Nat. Genet.
  doi: 10.1038/ng.401
– volume: 22
  start-page: 301
  year: 2021
  ident: 29514_CR73
  publication-title: Nat. Immunol.
  doi: 10.1038/s41590-021-00871-y
– volume: 129
  start-page: 2251
  year: 2019
  ident: 29514_CR74
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI125116
– volume: 14
  start-page: 471
  year: 2013
  ident: 29514_CR26
  publication-title: Genes Immun.
  doi: 10.1038/gene.2013.42
– volume: 90
  start-page: 648
  year: 2012
  ident: 29514_CR25
  publication-title: Am. J. Hum. Genet.
  doi: 10.1016/j.ajhg.2012.02.023
– volume: 329
  start-page: 689
  year: 2010
  ident: 29514_CR49
  publication-title: Science
  doi: 10.1126/science.1192002
– volume: 12
  year: 2021
  ident: 29514_CR16
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-021-21049-y
– volume: 50
  start-page: 699
  year: 2018
  ident: 29514_CR55
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0102-3
– volume: 46
  start-page: 205
  year: 2014
  ident: 29514_CR67
  publication-title: Nat. Genet
  doi: 10.1038/ng.2871
– volume: 291
  start-page: 13535
  year: 2016
  ident: 29514_CR32
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M115.705467
– volume: 22
  start-page: 59
  year: 2021
  ident: 29514_CR53
  publication-title: Nat. Rev. Genet.
  doi: 10.1038/s41576-020-00287-8
– volume: 191
  start-page: 3753
  year: 2013
  ident: 29514_CR33
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1202341
– volume: 13
  start-page: 4218
  year: 2008
  ident: 29514_CR58
  publication-title: Front. Biosci.
  doi: 10.2741/3001
– volume: 175
  start-page: 1701
  year: 2018
  ident: 29514_CR20
  publication-title: Cell Gene Expr. Cell
– volume: 27
  start-page: 1872
  year: 2017
  ident: 29514_CR8
  publication-title: Genome Res.
  doi: 10.1101/gr.216747.116
– volume: 354
  start-page: 769
  year: 2016
  ident: 29514_CR42
  publication-title: Science
  doi: 10.1126/science.aag2445
– volume: 12
  year: 2011
  ident: 29514_CR44
  publication-title: Genome Biol.
  doi: 10.1186/gb-2011-12-8-r83
– volume: 44
  start-page: 1336
  year: 2012
  ident: 29514_CR34
  publication-title: Nat. Genet.
  doi: 10.1038/ng.2462
– volume: 7
  start-page: e1002178
  year: 2011
  ident: 29514_CR36
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002178
– volume: 517
  start-page: 583
  year: 2015
  ident: 29514_CR41
  publication-title: Nature
  doi: 10.1038/nature14136
– volume: 51
  start-page: 1137
  year: 2019
  ident: 29514_CR59
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-019-0457-0
– volume: 17
  start-page: 545
  year: 2017
  ident: 29514_CR18
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2017.52
– volume: 108
  start-page: 5290
  year: 2011
  ident: 29514_CR56
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1017214108
– volume: 10
  year: 2019
  ident: 29514_CR37
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-019-12760-y
– volume: 110
  start-page: 2940
  year: 2013
  ident: 29514_CR71
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1222798110
– volume: 216
  start-page: 1154
  year: 2019
  ident: 29514_CR80
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20190185
– volume: 518
  start-page: 337
  year: 2015
  ident: 29514_CR14
  publication-title: Nature
  doi: 10.1038/nature13835
– volume: 173
  start-page: 430
  year: 2018
  ident: 29514_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2018.03.016
– ident: 29514_CR29
  doi: 10.1210/clinem/dgz239
– volume: 47
  start-page: e31
  year: 2019
  ident: 29514_CR45
  publication-title: Nucleic Acids Res.
  doi: 10.1093/nar/gkz020
– volume: 144
  start-page: 327
  year: 2011
  ident: 29514_CR69
  publication-title: Cell
  doi: 10.1016/j.cell.2011.01.024
– volume: 7
  start-page: e1002097
  year: 2011
  ident: 29514_CR47
  publication-title: PLoS Genet.
  doi: 10.1371/journal.pgen.1002097
– volume: 41
  start-page: 506
  year: 2018
  ident: 29514_CR64
  publication-title: Mol. Cells
– volume: 282
  start-page: 85
  year: 2015
  ident: 29514_CR39
  publication-title: J. Neuroimmunol.
  doi: 10.1016/j.jneuroim.2015.03.015
– volume: 77
  start-page: 1070
  year: 2018
  ident: 29514_CR9
  publication-title: Ann. Rheum. Dis.
  doi: 10.1136/annrheumdis-2017-212794
– volume: 50
  start-page: 493
  year: 2018
  ident: 29514_CR19
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-018-0089-9
– volume: 104
  start-page: 102315
  year: 2019
  ident: 29514_CR13
  publication-title: J. Autoimmun.
  doi: 10.1016/j.jaut.2019.102315
– volume: 47
  start-page: 1457
  year: 2015
  ident: 29514_CR38
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3434
– volume: 17
  start-page: 85
  year: 2015
  ident: 29514_CR28
  publication-title: Arthritis Res Ther.
  doi: 10.1186/s13075-015-0602-9
– volume: 6
  start-page: 182
  year: 2013
  ident: 29514_CR52
  publication-title: J. Comput. Sci. Syst. Biol.
  doi: 10.4172/jcsb.1000115
– reference: 35538211 - Nat Rev Rheumatol. 2022 Jun;18(6):306
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Snippet Despite strong evidence that human genetic variants affect the expression of many key transcription factors involved in autoimmune diseases, establishing...
The functional effects of genetic loci associated with autoimmune disease are not well understood. By dissecting an autoimmune disease genetic locus, the...
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Autoimmune diseases
Autoimmune Diseases - genetics
Chromatin
CRISPR
DNA methylation
DNA Methylation - genetics
Gene expression
Gene loci
Genetic diversity
Genetic variance
Humanities and Social Sciences
Humans
Immune system
Interferon Regulatory Factors - genetics
Interferon Regulatory Factors - metabolism
Lupus
Mixed Function Oxygenases - metabolism
Molecular modelling
multidisciplinary
Proto-Oncogene Proteins - metabolism
PU.1 protein
Regulatory Sequences, Nucleic Acid
Risk
RNA, Long Noncoding - genetics
RNA, Long Noncoding - metabolism
Science
Science (multidisciplinary)
Systemic lupus erythematosus
Transcription factors
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Title Lupus enhancer risk variant causes dysregulation of IRF8 through cooperative lncRNA and DNA methylation machinery
URI https://link.springer.com/article/10.1038/s41467-022-29514-y
https://www.ncbi.nlm.nih.gov/pubmed/35388006
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https://www.proquest.com/docview/2648065457
https://pubmed.ncbi.nlm.nih.gov/PMC8987079
https://doaj.org/article/b834bed781e544609a560d62e4f3795e
Volume 13
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