Contribution of the Gut Microbiome to Drug Disposition, Pharmacokinetic and Pharmacodynamic Variability

• Published in: Clinical pharmacokinetics Vol. 60; no. 8; pp. 971 - 984
• Main Authors: Tsunoda, Shirley M., Gonzales, Christopher, Jarmusch, Alan K., Momper, Jeremiah D., Ma, Joseph D.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.08.2021; Springer Nature B.V
• Subjects: Anti-inflammatory agents; Antibiotics; Bacteria; Bile; Bioavailability; Chemotherapy; Digestive system; Drugs; Enzymes; Gene expression; Gut microbiota; Internal Medicine; Liver; Medicine; Medicine & Public Health; Metabolism; Metabolites; Microbiota; Pharmacodynamics; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Precision medicine; Review; Review Article; Toxicity; Transplants & implants

The trillions of microbes that make up the gut microbiome are an important contributor to health and disease. With respect to xenobiotics, particularly orally administered compounds, the gut microbiome interacts directly with drugs to break them down into metabolic products. In addition, microbial p...