Self-implantable double-layered micro-drug-reservoirs for efficient and controlled ocular drug delivery

• Published in: Nature communications Vol. 9; no. 1; pp. 4433 - 12
• Main Authors: Than, Aung, Liu, Chenghao, Chang, Hao, Duong, Phan Khanh, Cheung, Chui Ming Gemmy, Xu, Chenjie, Wang, Xiaomeng, Chen, Peng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 06.11.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 631/154/152; 631/61/54/990; Angiogenesis; Animals; Controlled release; Cornea; Delayed-Action Preparations; Diclofenac; Drug delivery; Drug Delivery Systems; Eye; Eye - drug effects; Eye diseases; Eye injuries; Humanities and Social Sciences; Inflammation; Inflammation - pathology; Mice; Monoclonal antibodies; multidisciplinary; Needles; Pharmaceutical Preparations - administration & dosage; Prostheses and Implants; Science; Science (multidisciplinary); Sus scrofa; Sustained release; Transdermal medication; Vascular Endothelial Growth Factor A - antagonists & inhibitors; Vascular Endothelial Growth Factor A - metabolism; Vascularization

Eye diseases and injuries impose a significant clinical problem worldwide. Safe and effective ocular drug delivery is, however, challenging due to the presence of ocular barriers. Here we report a strategy using an eye patch equipped with an array of detachable microneedles. These microneedles can p...