Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

• Published in: Nature communications Vol. 12; no. 1; pp. 741 - 18
• Main Authors: Liu, Yang, He, Shuai, Wang, Xi-Liang, Peng, Wan, Chen, Qiu-Yan, Chi, Dong-Mei, Chen, Jie-Rong, Han, Bo-Wei, Lin, Guo-Wang, Li, Yi-Qi, Wang, Qian-Yu, Peng, Rou-Jun, Wei, Pan-Pan, Guo, Xiang, Li, Bo, Xia, Xiaojun, Mai, Hai-Qiang, Hu, Xue-Da, Zhang, Zemin, Zeng, Yi-Xin, Bei, Jin-Xin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 38/39; 631/250/580; 631/67/1536; 631/67/2329; 631/67/327; 82/51; 96/31; Cancer; CD8 antigen; CD8-Positive T-Lymphocytes - enzymology; CD8-Positive T-Lymphocytes - metabolism; Cell interactions; Cells, Cultured; CX3CR1 protein; Dendritic cells; Dendritic Cells - immunology; Dendritic Cells - metabolism; Epstein-Barr virus; Gene expression; Head and Neck Neoplasms - immunology; Head and Neck Neoplasms - metabolism; Heterogeneity; High-Throughput Nucleotide Sequencing; Humanities and Social Sciences; Humans; Lymphocytes; Lymphocytes T; Male; Microenvironments; multidisciplinary; Nasopharyngeal carcinoma; Nasopharyngeal Carcinoma - immunology; Nasopharyngeal Carcinoma - metabolism; Science; Science (multidisciplinary); T cell receptors; T-Lymphocytes, Regulatory - immunology; T-Lymphocytes, Regulatory - metabolism; Throat cancer; Trajectory analysis; Transcriptomes; Tumor microenvironment; Tumor Microenvironment - immunology; Tumor Microenvironment - physiology; Tumors

The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses rev...