Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution

The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses rev...

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Published inNature communications Vol. 12; no. 1; pp. 741 - 18
Main Authors Liu, Yang, He, Shuai, Wang, Xi-Liang, Peng, Wan, Chen, Qiu-Yan, Chi, Dong-Mei, Chen, Jie-Rong, Han, Bo-Wei, Lin, Guo-Wang, Li, Yi-Qi, Wang, Qian-Yu, Peng, Rou-Jun, Wei, Pan-Pan, Guo, Xiang, Li, Bo, Xia, Xiaojun, Mai, Hai-Qiang, Hu, Xue-Da, Zhang, Zemin, Zeng, Yi-Xin, Bei, Jin-Xin
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 02.02.2021
Nature Publishing Group
Nature Portfolio
Subjects
38/39
631/250/580
631/67/1536
631/67/2329
631/67/327
82/51
96/31
Cancer
CD8 antigen
CD8-Positive T-Lymphocytes - enzymology
CD8-Positive T-Lymphocytes - metabolism
Cell interactions
Cells, Cultured
CX3CR1 protein
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Epstein-Barr virus
Gene expression
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - metabolism
Heterogeneity
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Lymphocytes
Lymphocytes T
Male
Microenvironments
multidisciplinary
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - immunology
Nasopharyngeal Carcinoma - metabolism
Science
Science (multidisciplinary)
T cell receptors
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Throat cancer
Trajectory analysis
Transcriptomes
Tumor microenvironment
Tumor Microenvironment - immunology
Tumor Microenvironment - physiology
Tumors
Online AccessGet full text

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Abstract The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8 + T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8 + T and immune-suppressive TNFRSF4 + Treg cells in tumours might derive from peripheral CX3CR1 + CD8 + T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3 + DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3 + DCs, Treg, exhausted CD8 + T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC. Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.
AbstractList Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8 + T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8 + T and immune-suppressive TNFRSF4 + Treg cells in tumours might derive from peripheral CX3CR1 + CD8 + T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3 + DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3 + DCs, Treg, exhausted CD8 + T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC. Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8 T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8 T and immune-suppressive TNFRSF4 Treg cells in tumours might derive from peripheral CX3CR1 CD8 T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3 DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3 DCs, Treg, exhausted CD8 T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC.
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8+ T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8+ T and immune-suppressive TNFRSF4+ Treg cells in tumours might derive from peripheral CX3CR1+CD8+ T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3+ DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3+ DCs, Treg, exhausted CD8+ T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC.Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the tumour microenvironment in 10 nasopharyngeal carcinoma tumours and identify different cell types including immune-suppressive T regulatory, tolerogenic dendritic, and exhausted CD8 T cells.
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8+ T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8+ T and immune-suppressive TNFRSF4+ Treg cells in tumours might derive from peripheral CX3CR1+CD8+ T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3+ DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3+ DCs, Treg, exhausted CD8+ T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC.The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8+ T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8+ T and immune-suppressive TNFRSF4+ Treg cells in tumours might derive from peripheral CX3CR1+CD8+ T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3+ DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3+ DCs, Treg, exhausted CD8+ T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC.
The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we profile 176,447 cells from 10 NPC tumour-blood pairs, using single-cell transcriptome coupled with T cell receptor sequencing. Our analyses reveal 53 cell subtypes, including tumour-infiltrating CD8 + T, regulatory T (Treg), and dendritic cells (DCs), as well as malignant cells with different Epstein-Barr virus infection status. Trajectory analyses reveal exhausted CD8 + T and immune-suppressive TNFRSF4 + Treg cells in tumours might derive from peripheral CX3CR1 + CD8 + T and naïve Treg cells, respectively. Moreover, we identify immune-regulatory and tolerogenic LAMP3 + DCs. Noteworthily, we observe intensive inter-cell interactions among LAMP3 + DCs, Treg, exhausted CD8 + T, and malignant cells, suggesting potential cross-talks to foster an immune-suppressive niche for the TME. Collectively, our study uncovers the heterogeneity and interacting molecules of the TME in NPC at single-cell resolution, which provide insights into the mechanisms underlying NPC progression and the development of precise therapies for NPC.
ArticleNumber 741
Author Wei, Pan-Pan
Zhang, Zemin
Zeng, Yi-Xin
Peng, Wan
Chen, Qiu-Yan
Bei, Jin-Xin
Liu, Yang
Chi, Dong-Mei
Guo, Xiang
Wang, Qian-Yu
Hu, Xue-Da
Chen, Jie-Rong
He, Shuai
Li, Bo
Wang, Xi-Liang
Li, Yi-Qi
Xia, Xiaojun
Mai, Hai-Qiang
Lin, Guo-Wang
Peng, Rou-Jun
Han, Bo-Wei
Author_xml – sequence: 1
  givenname: Yang
  surname: Liu
  fullname: Liu, Yang
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
– sequence: 2
  givenname: Shuai
  orcidid: 0000-0001-6619-1039
  surname: He
  fullname: He, Shuai
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, The Eighth Affiliated Hospital, Sun Yat-sen University, Center for Precision Medicine, Sun Yat-sen University
– sequence: 3
  givenname: Xi-Liang
  surname: Wang
  fullname: Wang, Xi-Liang
  organization: BIOPIC, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University
– sequence: 4
  givenname: Wan
  surname: Peng
  fullname: Peng, Wan
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
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  givenname: Qiu-Yan
  surname: Chen
  fullname: Chen, Qiu-Yan
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
– sequence: 6
  givenname: Dong-Mei
  surname: Chi
  fullname: Chi, Dong-Mei
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Anesthesiology, Sun Yat-sen University Cancer Center
– sequence: 7
  givenname: Jie-Rong
  surname: Chen
  fullname: Chen, Jie-Rong
  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangdong General Hospital, Guangdong Academy of Medical Sciences
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  fullname: Lin, Guo-Wang
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  givenname: Yi-Qi
  surname: Li
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  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
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  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
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  orcidid: 0000-0002-7979-8339
  surname: Li
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  organization: Department of Biochemistry and Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, RNA Biomedical Institute, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
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  givenname: Xiaojun
  orcidid: 0000-0003-4444-7472
  surname: Xia
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  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy
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  organization: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, The Eighth Affiliated Hospital, Sun Yat-sen University, Center for Precision Medicine, Sun Yat-sen University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33531485$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1038/cmi.2014.52
10.1016/j.cell.2018.11.043
10.1016/j.semcancer.2012.01.002
10.1016/j.celrep.2017.06.062
10.1186/s40880-016-0103-5
10.1038/s41588-020-0636-z
10.1186/1471-2105-7-S1-S7
10.1016/j.immuni.2019.10.009
10.1200/JCO.2017.77.0388
10.1111/cas.14069
10.7150/jca.27611
10.1093/nar/gkz874
10.1007/978-3-030-35582-1_8
10.1016/j.cell.2020.03.048
10.1200/JCO.2005.02.147
10.2217/fmb.12.95
10.1002/ijc.31279
10.1097/CJI.0b013e318241d9de
10.1016/S1470-2045(16)30410-7
10.1038/s41586-018-0698-6
10.1038/s43018-020-0075-x
10.1158/0008-5472.CAN-05-2018
10.1016/S0065-230X(10)07003-X
10.1007/978-981-10-5765-6_6
10.2174/1872214811307020006
10.1097/CJI.0b013e31828bd87b
10.1016/j.cell.2018.05.060
10.1002/ijc.32099
10.1038/s41586-018-0694-x
10.1016/S1470-2045(19)30799-5
10.1038/s41591-018-0045-3
10.1158/1541-7786.MCR-17-0134
10.1016/j.canlet.2020.02.010
10.1038/cr.2016.151
10.5281/zenodo.4287763
10.1126/science.aad0501
10.1016/j.cell.2011.02.013
10.1080/2162402X.2014.998538
10.1038/nmeth.1923
10.1038/s41586-020-2134-y
10.1038/nmeth.3317
10.1093/bioinformatics/btu638
10.1158/0008-5472.CAN-11-3687
10.1016/j.immuni.2019.03.009
10.1038/s41564-017-0080-8
10.1016/j.imbio.2016.09.012
10.1093/annonc/mdx237
10.1016/j.tim.2010.04.001
10.1038/sj.bjc.6603580
10.1038/s41422-020-0374-x
10.1186/s40425-016-0125-1
10.1038/ncomms14121
10.1242/dev.177428
10.1038/ng.3006
10.1146/annurev-immunol-032713-120145
10.1038/s41591-018-0096-5
10.1016/S0167-5699(98)01307-3
10.1038/nbt.3192
10.1038/ni.2370
10.1038/s41422-019-0195-y
10.1002/path.4239
10.1186/1476-4598-9-4
10.1073/pnas.1621280114
10.3390/vaccines4030028
10.1016/j.cels.2015.12.004
10.1007/978-1-4939-6655-4_7
10.3390/cancers10080247
10.1200/JCO.2017.73.3675
10.3892/or.2012.1830
10.1002/ijc.23392
10.1016/S0140-6736(19)30956-0
10.1038/ni.3540
10.1016/j.immuni.2016.10.021
10.1002/kjm2.12087
10.5732/cjc.014.10208
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References Jang (CR62) 2017; 20
Chung (CR1) 2013; 231
Anders, Pyl, Huber (CR75) 2015; 31
Peng (CR67) 2019; 29
Velapasamy, Dawson, Young, Paterson, Yap (CR39) 2018; 10
Zhang (CR71) 2017; 15
Zhang (CR24) 2018; 564
Sun (CR3) 2016; 17
Lin (CR72) 2020; 21
Siddiqui, Erreni, van Brakel, Debets, Allavena (CR45) 2016; 4
Liberzon (CR70) 2015; 1
Zander (CR44) 2019; 51
Ruiz Garcia (CR32) 2019; 146
Hanahan, Weinberg (CR10) 2011; 144
Yu (CR41) 2012; 28
Zhang (CR68) 2020; 181
Mougiakakos, Choudhury, Lladser, Kiessling, Johansson (CR46) 2010; 107
Collins, Berry, Hyde, Stower, Maitland (CR49) 2005; 65
Mizukami (CR59) 2008; 122
Lau (CR14) 2007; 96
Zhao (CR17) 2020; 477
Facciabene, Motz, Coukos (CR47) 2012; 72
Miller (CR31) 2012; 13
Ma (CR6) 2018; 36
De Simone (CR48) 2016; 45
Chinen (CR25) 2016; 17
Maier (CR51) 2020; 580
Vento-Tormo (CR35) 2018; 563
Li (CR4) 2019; 145
Zhang (CR34) 2018; 3
Sanchez-Paulete (CR63) 2017; 28
Lee (CR66) 2020; 52
Hsu (CR7) 2017; 35
Ohue, Nishikawa (CR36) 2019; 110
Young, Dawson (CR33) 2014; 33
Wu, Gong, Liu (CR60) 2018; 17
Cheng, Pekkonen, Ojala (CR54) 2012; 7
Margolin (CR76) 2006; 7
de Oliveira, Ballon, Cesarman (CR53) 2010; 18
Zhang, Jia, Tsang, Tsao (CR58) 2017; 1018
Peng (CR64) 2018; 9
Wang (CR13) 2016; 35
O’Grady, Baddoo, Flemington (CR65) 2017; 1532
Xu (CR21) 2017; 222
Kim, Langmead, Salzberg (CR74) 2015; 12
Lin (CR8) 2014; 46
Zhang (CR15) 2010; 9
Li (CR57) 2012; 35
Perry, Whyte (CR20) 1998; 19
Apetoh (CR42) 2015; 4
Lambrechts (CR12) 2018; 24
Li (CR56) 2013; 36
Li (CR9) 2017; 8
Guo (CR11) 2018; 24
Liu (CR37) 2020; 1223
Oh (CR52) 2020; 1
Chaudhary, Elkord (CR27) 2016; 4
Azizi (CR50) 2018; 174
Bagaev (CR22) 2020; 48
Chen (CR2) 2019; 394
Tirosh (CR69) 2016; 352
Langmead, Salzberg (CR73) 2012; 9
Chan (CR5) 2005; 23
Li (CR43) 2019; 176
Barsheshet (CR26) 2017; 114
Griffith, Sokol, Luster (CR23) 2014; 32
Tanaka, Sakaguchi (CR61) 2017; 27
Satija, Farrell, Gennert, Schier, Regev (CR19) 2015; 33
Zhang (CR28) 2019; 179
Fujihara (CR38) 2013; 7
Yang Liu (CR77) 2020
Chen (CR18) 2020; 30
Shen, Zeng (CR40) 2019; 35
Wang (CR16) 2018; 142
Zilionis (CR29) 2019; 50
Li, Shi (CR30) 2015; 12
Gourzones, Barjon, Busson (CR55) 2012; 22
J Zhang (21043_CR58) 2017; 1018
C Hsu (21043_CR7) 2017; 35
F Cheng (21043_CR54) 2012; 7
AA Margolin (21043_CR76) 2006; 7
B Chaudhary (21043_CR27) 2016; 4
A Facciabene (21043_CR47) 2012; 72
JE Jang (21043_CR62) 2017; 20
B Maier (21043_CR51) 2020; 580
X Xu (21043_CR21) 2017; 222
S Velapasamy (21043_CR39) 2018; 10
C Gourzones (21043_CR55) 2012; 22
I Tirosh (21043_CR69) 2016; 352
YP Chen (21043_CR18) 2020; 30
H Wu (21043_CR60) 2018; 17
JC Miller (21043_CR31) 2012; 13
L Zhang (21043_CR71) 2017; 15
AT Chan (21043_CR5) 2005; 23
L Apetoh (21043_CR42) 2015; 4
H Zhang (21043_CR34) 2018; 3
HY Wang (21043_CR13) 2016; 35
KM Lau (21043_CR14) 2007; 96
H Li (21043_CR43) 2019; 176
DV Bagaev (21043_CR22) 2020; 48
JW Griffith (21043_CR23) 2014; 32
E Azizi (21043_CR50) 2018; 174
YL Zhang (21043_CR15) 2010; 9
YY Li (21043_CR9) 2017; 8
Y Mizukami (21043_CR59) 2008; 122
SH Yang Liu (21043_CR77) 2020
WF Li (21043_CR4) 2019; 145
T Chinen (21043_CR25) 2016; 17
R Zilionis (21043_CR29) 2019; 50
J Peng (21043_CR67) 2019; 29
Y Sun (21043_CR3) 2016; 17
S Ruiz Garcia (21043_CR32) 2019; 146
DC Lin (21043_CR8) 2014; 46
J Zhao (21043_CR17) 2020; 477
LS Young (21043_CR33) 2014; 33
Y Barsheshet (21043_CR26) 2017; 114
S Fujihara (21043_CR38) 2013; 7
F Li (21043_CR56) 2013; 36
M Perry (21043_CR20) 1998; 19
ED Shen (21043_CR40) 2019; 35
I Siddiqui (21043_CR45) 2016; 4
R Satija (21043_CR19) 2015; 33
L Zhang (21043_CR24) 2018; 564
D Kim (21043_CR74) 2015; 12
D Mougiakakos (21043_CR46) 2010; 107
BBY Ma (21043_CR6) 2018; 36
R Zander (21043_CR44) 2019; 51
Q Zhang (21043_CR28) 2019; 179
R Vento-Tormo (21043_CR35) 2018; 563
S Yu (21043_CR41) 2012; 28
X Guo (21043_CR11) 2018; 24
AT Collins (21043_CR49) 2005; 65
JJ Li (21043_CR57) 2012; 35
HO Lee (21043_CR66) 2020; 52
YP Chen (21043_CR2) 2019; 394
D Hanahan (21043_CR10) 2011; 144
B Langmead (21043_CR73) 2012; 9
D Lambrechts (21043_CR12) 2018; 24
S Anders (21043_CR75) 2015; 31
M De Simone (21043_CR48) 2016; 45
T O’Grady (21043_CR65) 2017; 1532
Y Ohue (21043_CR36) 2019; 110
JQ Liu (21043_CR37) 2020; 1223
GT Chung (21043_CR1) 2013; 231
A Tanaka (21043_CR61) 2017; 27
A Liberzon (21043_CR70) 2015; 1
GW Lin (21043_CR72) 2020; 21
DE de Oliveira (21043_CR53) 2010; 18
YQ Wang (21043_CR16) 2018; 142
SA Oh (21043_CR52) 2020; 1
L Peng (21043_CR64) 2018; 9
AR Sanchez-Paulete (21043_CR63) 2017; 28
L Zhang (21043_CR68) 2020; 181
H Li (21043_CR30) 2015; 12
References_xml – volume: 12
  start-page: 24
  year: 2015
  end-page: 30
  ident: CR30
  article-title: Tolerogenic dendritic cells and their applications in transplantation
  publication-title: Cell Mol. Immunol.
  doi: 10.1038/cmi.2014.52
– volume: 176
  start-page: 775
  year: 2019
  end-page: 789 e718
  ident: CR43
  article-title: Dysfunctional CD8 T cells form a proliferative, dynamically regulated compartment within human melanoma
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.043
– volume: 22
  start-page: 127
  year: 2012
  end-page: 136
  ident: CR55
  article-title: Host-tumor interactions in nasopharyngeal carcinomas
  publication-title: Semin Cancer Biol.
  doi: 10.1016/j.semcancer.2012.01.002
– volume: 20
  start-page: 558
  year: 2017
  end-page: 571
  ident: CR62
  article-title: Crosstalk between regulatory T cells and Tumor-associated dendritic cells negates anti-tumor immunity in pancreatic cancer
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.06.062
– volume: 35
  year: 2016
  ident: CR13
  article-title: A new prognostic histopathologic classification of nasopharyngeal carcinoma
  publication-title: Chin. J. Cancer
  doi: 10.1186/s40880-016-0103-5
– volume: 52
  start-page: 594
  year: 2020
  end-page: 603
  ident: CR66
  article-title: Lineage-dependent gene expression programs influence the immune landscape of colorectal cancer
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-020-0636-z
– volume: 7
  issue: Suppl 1
  year: 2006
  ident: CR76
  article-title: ARACNE: an algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-7-S1-S7
– volume: 51
  start-page: 1028
  year: 2019
  end-page: 1042 e1024
  ident: CR44
  article-title: CD4(+) T cell help is required for the formation of a cytolytic CD8(+) T cell subset that protects against chronic infection and cancer
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.10.009
– volume: 36
  start-page: 1412
  year: 2018
  end-page: 1418
  ident: CR6
  article-title: Antitumor activity of nivolumab in recurrent and metastatic nasopharyngeal carcinoma: an International, Multicenter Study of the Mayo Clinic Phase 2 Consortium (NCI-9742)
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.77.0388
– volume: 110
  start-page: 2080
  year: 2019
  end-page: 2089
  ident: CR36
  article-title: Regulatory T (Treg) cells in cancer: can Treg cells be a new therapeutic target?
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14069
– volume: 9
  start-page: 4510
  year: 2018
  end-page: 4520
  ident: CR64
  article-title: The efficacy and safety of anti-epidermal growth factor receptor monoclonal antibodies in nasopharyngeal carcinoma: literature-based meta-analyses
  publication-title: J. Cancer
  doi: 10.7150/jca.27611
– volume: 48
  start-page: D1057
  year: 2020
  end-page: D1062
  ident: CR22
  article-title: VDJdb in 2019: database extension, new analysis infrastructure and a T-cell receptor motif compendium
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz874
– volume: 17
  start-page: 4867
  year: 2018
  end-page: 4873
  ident: CR60
  article-title: Indoleamine 2, 3-dioxygenase regulation of immune response (Review)
  publication-title: Mol. Med. Rep.
– volume: 1223
  start-page: 155
  year: 2020
  end-page: 165
  ident: CR37
  article-title: CD200-CD200R Pathway in the Regulation of Tumor Immune Microenvironment and Immunotherapy
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-030-35582-1_8
– volume: 181
  start-page: 442
  year: 2020
  end-page: 459 e429
  ident: CR68
  article-title: Single-cell analyses inform mechanisms of myeloid-targeted therapies in colon cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.048
– volume: 23
  start-page: 3568
  year: 2005
  end-page: 3576
  ident: CR5
  article-title: Multicenter, phase II study of cetuximab in combination with carboplatin in patients with recurrent or metastatic nasopharyngeal carcinoma
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2005.02.147
– volume: 35
  start-page: 474
  year: 2019
  end-page: 485
  ident: CR40
  article-title: Inhibition of the Numb/Notch signaling pathway increases radiation sensitivity in human nasopharyngeal carcinoma cells
  publication-title: Kaohsiung J. Med. Sci.
– volume: 7
  start-page: 1191
  year: 2012
  end-page: 1205
  ident: CR54
  article-title: Instigation of Notch signaling in the pathogenesis of Kaposi’s sarcoma-associated herpesvirus and other human tumor viruses
  publication-title: Future Microbiol
  doi: 10.2217/fmb.12.95
– volume: 142
  start-page: 2558
  year: 2018
  end-page: 2566
  ident: CR16
  article-title: Prognostic significance of tumor-infiltrating lymphocytes in nondisseminated nasopharyngeal carcinoma: a large-scale cohort study
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.31279
– volume: 35
  start-page: 189
  year: 2012
  end-page: 195
  ident: CR57
  article-title: Autologous cytokine-induced killer cell transfusion in combination with gemcitabine plus cisplatin regimen chemotherapy for metastatic nasopharyngeal carcinoma
  publication-title: J. Immunother.
  doi: 10.1097/CJI.0b013e318241d9de
– volume: 17
  start-page: 1509
  year: 2016
  end-page: 1520
  ident: CR3
  article-title: Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(16)30410-7
– volume: 563
  start-page: 347
  year: 2018
  end-page: 353
  ident: CR35
  article-title: Single-cell reconstruction of the early maternal-fetal interface in humans
  publication-title: Nature
  doi: 10.1038/s41586-018-0698-6
– volume: 1
  start-page: 681
  year: 2020
  end-page: 691
  ident: CR52
  article-title: PD-L1 expression by dendritic cells is a key regulator of T-cell immunity in cancer
  publication-title: Nat. Cancer
  doi: 10.1038/s43018-020-0075-x
– volume: 65
  start-page: 10946
  year: 2005
  end-page: 10951
  ident: CR49
  article-title: Prospective identification of tumorigenic prostate cancer stem cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-2018
– volume: 107
  start-page: 57
  year: 2010
  end-page: 117
  ident: CR46
  article-title: Regulatory T cells in cancer
  publication-title: Adv. Cancer Res.
  doi: 10.1016/S0065-230X(10)07003-X
– volume: 1018
  start-page: 75
  year: 2017
  end-page: 90
  ident: CR58
  article-title: EBV infection and glucose metabolism in nasopharyngeal carcinoma
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-981-10-5765-6_6
– volume: 7
  start-page: 130
  year: 2013
  end-page: 137
  ident: CR38
  article-title: Galectin-9 in cancer therapy
  publication-title: Recent Pat. Endocr. Metab. Immune Drug Disco.
  doi: 10.2174/1872214811307020006
– volume: 36
  start-page: 208
  year: 2013
  end-page: 214
  ident: CR56
  article-title: Delayed-type hypersensitivity (DTH) immune response related with EBV-DNA in nasopharyngeal carcinoma treated with autologous dendritic cell vaccination after radiotherapy
  publication-title: J. Immunother.
  doi: 10.1097/CJI.0b013e31828bd87b
– volume: 174
  start-page: 1293
  year: 2018
  end-page: 1308 e1236
  ident: CR50
  article-title: Single-cell map of diverse immune phenotypes in the breast tumor microenvironment
  publication-title: Cell
  doi: 10.1016/j.cell.2018.05.060
– volume: 145
  start-page: 295
  year: 2019
  end-page: 305
  ident: CR4
  article-title: Concurrent chemoradiotherapy with/without induction chemotherapy in locoregionally advanced nasopharyngeal carcinoma: Long-term results of phase 3 randomized controlled trial
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.32099
– volume: 564
  start-page: 268
  year: 2018
  end-page: 272
  ident: CR24
  article-title: Lineage tracking reveals dynamic relationships of T cells in colorectal cancer
  publication-title: Nature
  doi: 10.1038/s41586-018-0694-x
– volume: 21
  start-page: 306
  year: 2020
  end-page: 316
  ident: CR72
  article-title: Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(19)30799-5
– volume: 24
  start-page: 978
  year: 2018
  end-page: 985
  ident: CR11
  article-title: Global characterization of T cells in non-small-cell lung cancer by single-cell sequencing
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0045-3
– volume: 15
  start-page: 1722
  year: 2017
  end-page: 1732
  ident: CR71
  article-title: Genomic analysis of nasopharyngeal carcinoma reveals TME-based subtypes
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-17-0134
– volume: 477
  start-page: 131
  year: 2020
  end-page: 143
  ident: CR17
  article-title: Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2020.02.010
– volume: 27
  start-page: 109
  year: 2017
  end-page: 118
  ident: CR61
  article-title: Regulatory T cells in cancer immunotherapy
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.151
– year: 2020
  ident: CR77
  article-title: Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
  publication-title: Zenodo
  doi: 10.5281/zenodo.4287763
– volume: 352
  start-page: 189
  year: 2016
  end-page: 196
  ident: CR69
  article-title: Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 144
  start-page: 646
  year: 2011
  end-page: 674
  ident: CR10
  article-title: Hallmarks of cancer: the next generation
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 4
  start-page: e998538
  year: 2015
  ident: CR42
  article-title: Consensus nomenclature for CD8(+) T cell phenotypes in cancer
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2014.998538
– volume: 9
  start-page: 357
  year: 2012
  end-page: 359
  ident: CR73
  article-title: Fast gapped-read alignment with Bowtie 2
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 580
  start-page: 257
  year: 2020
  end-page: 262
  ident: CR51
  article-title: A conserved dendritic-cell regulatory program limits antitumour immunity
  publication-title: Nature
  doi: 10.1038/s41586-020-2134-y
– volume: 12
  start-page: 357
  year: 2015
  end-page: 360
  ident: CR74
  article-title: HISAT: a fast spliced aligner with low memory requirements
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3317
– volume: 31
  start-page: 166
  year: 2015
  end-page: 169
  ident: CR75
  article-title: HTSeq–a Python framework to work with high-throughput sequencing data
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 72
  start-page: 2162
  year: 2012
  end-page: 2171
  ident: CR47
  article-title: T-regulatory cells: key players in tumor immune escape and angiogenesis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-3687
– volume: 50
  start-page: 1317
  year: 2019
  end-page: 1334 e1310
  ident: CR29
  article-title: Single-cell transcriptomics of human and mouse lung cancers reveals conserved myeloid populations across individuals and species
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.009
– volume: 3
  start-page: 1
  year: 2018
  end-page: 8
  ident: CR34
  article-title: Ephrin receptor A2 is an epithelial cell receptor for Epstein-Barr virus entry
  publication-title: Nat. Microbiol
  doi: 10.1038/s41564-017-0080-8
– volume: 222
  start-page: 280
  year: 2017
  end-page: 290
  ident: CR21
  article-title: IFN-gamma-producing Th1-like regulatory T cells may limit acute cellular renal allograft rejection: Paradoxical post-transplantation effects of IFN-gamma
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2016.09.012
– volume: 28
  start-page: xii44
  year: 2017
  end-page: xii55
  ident: CR63
  article-title: Antigen cross-presentation and T-cell cross-priming in cancer immunology and immunotherapy
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdx237
– volume: 18
  start-page: 248
  year: 2010
  end-page: 257
  ident: CR53
  article-title: NF-kappaB signaling modulation by EBV and KSHV
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2010.04.001
– volume: 96
  start-page: 617
  year: 2007
  end-page: 622
  ident: CR14
  article-title: Increase in circulating Foxp3+CD4+CD25(high) regulatory T cells in nasopharyngeal carcinoma patients
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6603580
– volume: 30
  start-page: 1024
  year: 2020
  end-page: 1042
  ident: CR18
  article-title: Single-cell transcriptomics reveals regulators underlying immune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0374-x
– volume: 4
  start-page: 21
  year: 2016
  ident: CR45
  article-title: Enhanced recruitment of genetically modified CX3CR1-positive human T cells into Fractalkine/CX3CL1 expressing tumors: importance of the chemokine gradient
  publication-title: J. Immunother. Cancer
  doi: 10.1186/s40425-016-0125-1
– volume: 8
  year: 2017
  ident: CR9
  article-title: Exome and genome sequencing of nasopharynx cancer identifies NF-kappaB pathway activating mutations
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14121
– volume: 146
  start-page: dev177428
  year: 2019
  ident: CR32
  article-title: Novel dynamics of human mucociliary differentiation revealed by single-cell RNA sequencing of nasal epithelial cultures
  publication-title: Development
  doi: 10.1242/dev.177428
– volume: 46
  start-page: 866
  year: 2014
  end-page: 871
  ident: CR8
  article-title: The genomic landscape of nasopharyngeal carcinoma
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3006
– volume: 32
  start-page: 659
  year: 2014
  end-page: 702
  ident: CR23
  article-title: Chemokines and chemokine receptors: positioning cells for host defense and immunity
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120145
– volume: 24
  start-page: 1277
  year: 2018
  end-page: 1289
  ident: CR12
  article-title: Phenotype molding of stromal cells in the lung tumor microenvironment
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0096-5
– volume: 19
  start-page: 414
  year: 1998
  end-page: 421
  ident: CR20
  article-title: Immunology of the tonsils
  publication-title: Immunol. Today
  doi: 10.1016/S0167-5699(98)01307-3
– volume: 33
  start-page: 495
  year: 2015
  end-page: 502
  ident: CR19
  article-title: Spatial reconstruction of single-cell gene expression data
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3192
– volume: 13
  start-page: 888
  year: 2012
  end-page: 899
  ident: CR31
  article-title: Deciphering the transcriptional network of the dendritic cell lineage
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2370
– volume: 29
  start-page: 725
  year: 2019
  end-page: 738
  ident: CR67
  article-title: Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma
  publication-title: Cell Res.
  doi: 10.1038/s41422-019-0195-y
– volume: 231
  start-page: 311
  year: 2013
  end-page: 322
  ident: CR1
  article-title: Constitutive activation of distinct NF-kappaB signals in EBV associated nasopharyngeal carcinoma
  publication-title: J. Pathol.
  doi: 10.1002/path.4239
– volume: 179
  start-page: 829
  year: 2019
  end-page: 845 e820
  ident: CR28
  article-title: Landscape and dynamics of single immune
  publication-title: Cells Hepatocell Carcinoma Cell
– volume: 9
  year: 2010
  ident: CR15
  article-title: Different subsets of tumor infiltrating lymphocytes correlate with NPC progression in different ways
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-4
– volume: 33
  start-page: 581
  year: 2014
  end-page: 590
  ident: CR33
  article-title: Epstein-Barr virus and nasopharyngeal carcinoma
  publication-title: Chin. J. Cancer
– volume: 114
  start-page: 6086
  year: 2017
  end-page: 6091
  ident: CR26
  article-title: CCR8(+)FOXp3(+) Treg cells as master drivers of immune regulation
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1621280114
– volume: 4
  start-page: 28
  year: 2016
  ident: CR27
  article-title: Regulatory T cells in the tumor microenvironment and cancer progression: role and therapeutic targeting
  publication-title: Vaccines
  doi: 10.3390/vaccines4030028
– volume: 1
  start-page: 417
  year: 2015
  end-page: 425
  ident: CR70
  article-title: The Molecular Signatures Database (MSigDB) hallmark gene set collection
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 1532
  start-page: 105
  year: 2017
  end-page: 121
  ident: CR65
  article-title: Analysis of EBV transcription using high-throughput RNA sequencing
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-6655-4_7
– volume: 10
  start-page: 247
  year: 2018
  ident: CR39
  article-title: The dynamic roles of TGF-beta signalling in EBV-associated cancers
  publication-title: Cancers
  doi: 10.3390/cancers10080247
– volume: 35
  start-page: 4050
  year: 2017
  end-page: 4056
  ident: CR7
  article-title: Safety and antitumor activity of pembrolizumab in patients with programmed death-ligand 1-positive nasopharyngeal carcinoma: results of the KEYNOTE-028 Study
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.73.3675
– volume: 28
  start-page: 561
  year: 2012
  end-page: 566
  ident: CR41
  article-title: Notch inhibition suppresses nasopharyngeal carcinoma by depleting cancer stem-like side population cells
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2012.1830
– volume: 122
  start-page: 2286
  year: 2008
  end-page: 2293
  ident: CR59
  article-title: CCL17 and CCL22 chemokines within tumor microenvironment are related to accumulation of Foxp3+ regulatory T cells in gastric cancer
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23392
– volume: 394
  start-page: 64
  year: 2019
  end-page: 80
  ident: CR2
  article-title: Nasopharyngeal carcinoma
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)30956-0
– volume: 17
  start-page: 1322
  year: 2016
  end-page: 1333
  ident: CR25
  article-title: An essential role for the IL-2 receptor in Treg cell function
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3540
– volume: 45
  start-page: 1135
  year: 2016
  end-page: 1147
  ident: CR48
  article-title: Transcriptional landscape of human tissue lymphocytes unveils uniqueness of tumor-infiltrating T regulatory cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.10.021
– volume: 145
  start-page: 295
  year: 2019
  ident: 21043_CR4
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.32099
– volume: 23
  start-page: 3568
  year: 2005
  ident: 21043_CR5
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2005.02.147
– volume: 52
  start-page: 594
  year: 2020
  ident: 21043_CR66
  publication-title: Nat. Genet.
  doi: 10.1038/s41588-020-0636-z
– volume: 231
  start-page: 311
  year: 2013
  ident: 21043_CR1
  publication-title: J. Pathol.
  doi: 10.1002/path.4239
– volume: 46
  start-page: 866
  year: 2014
  ident: 21043_CR8
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3006
– volume: 110
  start-page: 2080
  year: 2019
  ident: 21043_CR36
  publication-title: Cancer Sci.
  doi: 10.1111/cas.14069
– volume: 1018
  start-page: 75
  year: 2017
  ident: 21043_CR58
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-981-10-5765-6_6
– volume: 7
  issue: Suppl 1
  year: 2006
  ident: 21043_CR76
  publication-title: BMC Bioinformatics
  doi: 10.1186/1471-2105-7-S1-S7
– volume: 179
  start-page: 829
  year: 2019
  ident: 21043_CR28
  publication-title: Cells Hepatocell Carcinoma Cell
– volume: 146
  start-page: dev177428
  year: 2019
  ident: 21043_CR32
  publication-title: Development
  doi: 10.1242/dev.177428
– volume: 176
  start-page: 775
  year: 2019
  ident: 21043_CR43
  publication-title: Cell
  doi: 10.1016/j.cell.2018.11.043
– volume: 580
  start-page: 257
  year: 2020
  ident: 21043_CR51
  publication-title: Nature
  doi: 10.1038/s41586-020-2134-y
– volume: 65
  start-page: 10946
  year: 2005
  ident: 21043_CR49
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-05-2018
– volume: 13
  start-page: 888
  year: 2012
  ident: 21043_CR31
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.2370
– volume: 4
  start-page: e998538
  year: 2015
  ident: 21043_CR42
  publication-title: Oncoimmunology
  doi: 10.1080/2162402X.2014.998538
– volume: 72
  start-page: 2162
  year: 2012
  ident: 21043_CR47
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-3687
– volume: 222
  start-page: 280
  year: 2017
  ident: 21043_CR21
  publication-title: Immunobiology
  doi: 10.1016/j.imbio.2016.09.012
– volume: 35
  start-page: 474
  year: 2019
  ident: 21043_CR40
  publication-title: Kaohsiung J. Med. Sci.
  doi: 10.1002/kjm2.12087
– volume: 394
  start-page: 64
  year: 2019
  ident: 21043_CR2
  publication-title: Lancet
  doi: 10.1016/S0140-6736(19)30956-0
– volume: 10
  start-page: 247
  year: 2018
  ident: 21043_CR39
  publication-title: Cancers
  doi: 10.3390/cancers10080247
– volume: 1223
  start-page: 155
  year: 2020
  ident: 21043_CR37
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-3-030-35582-1_8
– volume: 12
  start-page: 357
  year: 2015
  ident: 21043_CR74
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.3317
– volume: 352
  start-page: 189
  year: 2016
  ident: 21043_CR69
  publication-title: Science
  doi: 10.1126/science.aad0501
– volume: 142
  start-page: 2558
  year: 2018
  ident: 21043_CR16
  publication-title: Int J. Cancer
  doi: 10.1002/ijc.31279
– volume: 114
  start-page: 6086
  year: 2017
  ident: 21043_CR26
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.1621280114
– volume: 15
  start-page: 1722
  year: 2017
  ident: 21043_CR71
  publication-title: Mol. Cancer Res.
  doi: 10.1158/1541-7786.MCR-17-0134
– volume: 9
  start-page: 4510
  year: 2018
  ident: 21043_CR64
  publication-title: J. Cancer
  doi: 10.7150/jca.27611
– volume: 4
  start-page: 28
  year: 2016
  ident: 21043_CR27
  publication-title: Vaccines
  doi: 10.3390/vaccines4030028
– volume: 51
  start-page: 1028
  year: 2019
  ident: 21043_CR44
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.10.009
– volume: 174
  start-page: 1293
  year: 2018
  ident: 21043_CR50
  publication-title: Cell
  doi: 10.1016/j.cell.2018.05.060
– volume: 22
  start-page: 127
  year: 2012
  ident: 21043_CR55
  publication-title: Semin Cancer Biol.
  doi: 10.1016/j.semcancer.2012.01.002
– volume: 477
  start-page: 131
  year: 2020
  ident: 21043_CR17
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2020.02.010
– volume: 122
  start-page: 2286
  year: 2008
  ident: 21043_CR59
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.23392
– volume: 107
  start-page: 57
  year: 2010
  ident: 21043_CR46
  publication-title: Adv. Cancer Res.
  doi: 10.1016/S0065-230X(10)07003-X
– volume: 96
  start-page: 617
  year: 2007
  ident: 21043_CR14
  publication-title: Br. J. Cancer
  doi: 10.1038/sj.bjc.6603580
– volume: 1
  start-page: 681
  year: 2020
  ident: 21043_CR52
  publication-title: Nat. Cancer
  doi: 10.1038/s43018-020-0075-x
– volume: 9
  year: 2010
  ident: 21043_CR15
  publication-title: Mol. Cancer
  doi: 10.1186/1476-4598-9-4
– volume: 31
  start-page: 166
  year: 2015
  ident: 21043_CR75
  publication-title: Bioinformatics
  doi: 10.1093/bioinformatics/btu638
– volume: 32
  start-page: 659
  year: 2014
  ident: 21043_CR23
  publication-title: Annu. Rev. Immunol.
  doi: 10.1146/annurev-immunol-032713-120145
– volume: 18
  start-page: 248
  year: 2010
  ident: 21043_CR53
  publication-title: Trends Microbiol.
  doi: 10.1016/j.tim.2010.04.001
– volume: 35
  start-page: 189
  year: 2012
  ident: 21043_CR57
  publication-title: J. Immunother.
  doi: 10.1097/CJI.0b013e318241d9de
– volume: 50
  start-page: 1317
  year: 2019
  ident: 21043_CR29
  publication-title: Immunity
  doi: 10.1016/j.immuni.2019.03.009
– volume: 8
  year: 2017
  ident: 21043_CR9
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms14121
– volume: 29
  start-page: 725
  year: 2019
  ident: 21043_CR67
  publication-title: Cell Res.
  doi: 10.1038/s41422-019-0195-y
– volume: 28
  start-page: xii44
  year: 2017
  ident: 21043_CR63
  publication-title: Ann. Oncol.
  doi: 10.1093/annonc/mdx237
– volume: 1532
  start-page: 105
  year: 2017
  ident: 21043_CR65
  publication-title: Methods Mol. Biol.
  doi: 10.1007/978-1-4939-6655-4_7
– volume: 36
  start-page: 208
  year: 2013
  ident: 21043_CR56
  publication-title: J. Immunother.
  doi: 10.1097/CJI.0b013e31828bd87b
– volume: 7
  start-page: 130
  year: 2013
  ident: 21043_CR38
  publication-title: Recent Pat. Endocr. Metab. Immune Drug Disco.
  doi: 10.2174/1872214811307020006
– volume: 21
  start-page: 306
  year: 2020
  ident: 21043_CR72
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(19)30799-5
– volume: 3
  start-page: 1
  year: 2018
  ident: 21043_CR34
  publication-title: Nat. Microbiol
  doi: 10.1038/s41564-017-0080-8
– volume: 28
  start-page: 561
  year: 2012
  ident: 21043_CR41
  publication-title: Oncol. Rep.
  doi: 10.3892/or.2012.1830
– volume: 35
  year: 2016
  ident: 21043_CR13
  publication-title: Chin. J. Cancer
  doi: 10.1186/s40880-016-0103-5
– volume: 4
  start-page: 21
  year: 2016
  ident: 21043_CR45
  publication-title: J. Immunother. Cancer
  doi: 10.1186/s40425-016-0125-1
– volume: 563
  start-page: 347
  year: 2018
  ident: 21043_CR35
  publication-title: Nature
  doi: 10.1038/s41586-018-0698-6
– volume: 30
  start-page: 1024
  year: 2020
  ident: 21043_CR18
  publication-title: Cell Res.
  doi: 10.1038/s41422-020-0374-x
– volume: 564
  start-page: 268
  year: 2018
  ident: 21043_CR24
  publication-title: Nature
  doi: 10.1038/s41586-018-0694-x
– volume: 45
  start-page: 1135
  year: 2016
  ident: 21043_CR48
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.10.021
– volume: 20
  start-page: 558
  year: 2017
  ident: 21043_CR62
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2017.06.062
– volume: 33
  start-page: 581
  year: 2014
  ident: 21043_CR33
  publication-title: Chin. J. Cancer
  doi: 10.5732/cjc.014.10208
– volume: 7
  start-page: 1191
  year: 2012
  ident: 21043_CR54
  publication-title: Future Microbiol
  doi: 10.2217/fmb.12.95
– volume: 24
  start-page: 1277
  year: 2018
  ident: 21043_CR12
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0096-5
– volume: 181
  start-page: 442
  year: 2020
  ident: 21043_CR68
  publication-title: Cell
  doi: 10.1016/j.cell.2020.03.048
– volume: 19
  start-page: 414
  year: 1998
  ident: 21043_CR20
  publication-title: Immunol. Today
  doi: 10.1016/S0167-5699(98)01307-3
– volume: 17
  start-page: 1322
  year: 2016
  ident: 21043_CR25
  publication-title: Nat. Immunol.
  doi: 10.1038/ni.3540
– volume: 12
  start-page: 24
  year: 2015
  ident: 21043_CR30
  publication-title: Cell Mol. Immunol.
  doi: 10.1038/cmi.2014.52
– volume: 27
  start-page: 109
  year: 2017
  ident: 21043_CR61
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.151
– volume: 144
  start-page: 646
  year: 2011
  ident: 21043_CR10
  publication-title: Cell
  doi: 10.1016/j.cell.2011.02.013
– volume: 17
  start-page: 1509
  year: 2016
  ident: 21043_CR3
  publication-title: Lancet Oncol.
  doi: 10.1016/S1470-2045(16)30410-7
– volume: 9
  start-page: 357
  year: 2012
  ident: 21043_CR73
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.1923
– volume: 48
  start-page: D1057
  year: 2020
  ident: 21043_CR22
  publication-title: Nucleic Acids Res
  doi: 10.1093/nar/gkz874
– volume: 17
  start-page: 4867
  year: 2018
  ident: 21043_CR60
  publication-title: Mol. Med. Rep.
– volume: 1
  start-page: 417
  year: 2015
  ident: 21043_CR70
  publication-title: Cell Syst.
  doi: 10.1016/j.cels.2015.12.004
– volume: 35
  start-page: 4050
  year: 2017
  ident: 21043_CR7
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.73.3675
– volume: 33
  start-page: 495
  year: 2015
  ident: 21043_CR19
  publication-title: Nat. Biotechnol.
  doi: 10.1038/nbt.3192
– volume: 36
  start-page: 1412
  year: 2018
  ident: 21043_CR6
  publication-title: J. Clin. Oncol.
  doi: 10.1200/JCO.2017.77.0388
– volume: 24
  start-page: 978
  year: 2018
  ident: 21043_CR11
  publication-title: Nat. Med.
  doi: 10.1038/s41591-018-0045-3
– year: 2020
  ident: 21043_CR77
  publication-title: Zenodo
  doi: 10.5281/zenodo.4287763
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Snippet The heterogeneous nature of tumour microenvironment (TME) underlying diverse treatment responses remains unclear in nasopharyngeal carcinoma (NPC). Here, we...
Nasopharyngeal carcinoma is a diverse cancer characterised by a heterogeneous microenvironment. Here, the authors use single cell sequencing to analyse the...
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StartPage 741
SubjectTerms 38/39
631/250/580
631/67/1536
631/67/2329
631/67/327
82/51
96/31
Cancer
CD8 antigen
CD8-Positive T-Lymphocytes - enzymology
CD8-Positive T-Lymphocytes - metabolism
Cell interactions
Cells, Cultured
CX3CR1 protein
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
Epstein-Barr virus
Gene expression
Head and Neck Neoplasms - immunology
Head and Neck Neoplasms - metabolism
Heterogeneity
High-Throughput Nucleotide Sequencing
Humanities and Social Sciences
Humans
Lymphocytes
Lymphocytes T
Male
Microenvironments
multidisciplinary
Nasopharyngeal carcinoma
Nasopharyngeal Carcinoma - immunology
Nasopharyngeal Carcinoma - metabolism
Science
Science (multidisciplinary)
T cell receptors
T-Lymphocytes, Regulatory - immunology
T-Lymphocytes, Regulatory - metabolism
Throat cancer
Trajectory analysis
Transcriptomes
Tumor microenvironment
Tumor Microenvironment - immunology
Tumor Microenvironment - physiology
Tumors
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Title Tumour heterogeneity and intercellular networks of nasopharyngeal carcinoma at single cell resolution
URI https://link.springer.com/article/10.1038/s41467-021-21043-4
https://www.ncbi.nlm.nih.gov/pubmed/33531485
https://www.proquest.com/docview/2485325094
https://www.proquest.com/docview/2486140749
https://pubmed.ncbi.nlm.nih.gov/PMC7854640
https://doaj.org/article/f1978be2a763451db9da5aca4be70f2e
Volume 12
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