HIF-1α promoted vasculogenic mimicry formation in lung adenocarcinoma through NRP1 upregulation in the hypoxic tumor microenvironment

• Published in: Cell death & disease Vol. 12; no. 4; p. 394
• Main Authors: Fu, Ran, Du, Wenwen, Ding, Zongli, Wang, Yi, Li, Yue, Zhu, Jianjie, Zeng, Yuanyuan, Zheng, Yulong, Liu, Zeyi, Huang, Jian-an
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 13.04.2021; Springer Nature B.V; Nature Publishing Group
• Subjects: 14/1; 14/19; 38/109; 38/89; 38/90; 42/44; 631/67/1612; 631/80/84; Adenocarcinoma; Antibodies; Biochemistry; Biomedical and Life Sciences; Cadherins; Cell Biology; Cell Culture; Cell migration; Gelatinase A; Hypoxia; Hypoxia-inducible factor 1a; Immunology; Invasiveness; Life Sciences; Lung cancer; Metastases; Metastasis; Mimicry; Tumor microenvironment; Tumors; Up-regulation; Vascularization; Vimentin; Wound healing

Neovascularization is a key factor that contributes to tumor metastasis, and vasculogenic mimicry (VM) is an important form of neovascularization found in highly invasive tumors, including lung cancer. Despite the increasing number of studies focusing on VM, the mechanisms underlying VM formation re...