Organocatalytic cycloaddition of alkynylindoles with azonaphthalenes for atroposelective construction of indole-based biaryls

• Published in: Nature communications Vol. 13; no. 1; pp. 632 - 9
• Main Authors: Yang, Hui, Sun, Huai-Ri, He, Rui-Qing, Yu, Le, Hu, Wei, Chen, Jie, Yang, Sen, Zhang, Gong-Gu, Zhou, Ling
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 02.02.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 119/118; 140/131; 140/58; 639/638/403; 639/638/403/933; 639/638/77/889; Bioactive compounds; Biological activity; Cycloaddition; Enantiomers; Humanities and Social Sciences; Indoles; multidisciplinary; Natural products; Phosphoric acid; Science; Science (multidisciplinary)

The axially chiral indole-aryl motifs are present in natural products and biologically active compounds as well as in chiral ligands. Atroposelective indole formation is an efficient method to construct indole-based biaryls. We report herein the result of a chiral phosphoric acid catalyzed asymmetri...