Leptin induces TNFα-dependent inflammation in acquired generalized lipodystrophy and combined Crohn’s disease

• Published in: Nature communications Vol. 10; no. 1; pp. 5629 - 11
• Main Authors: Ziegler, Jörn F., Böttcher, Chotima, Letizia, Marilena, Yerinde, Cansu, Wu, Hao, Freise, Inka, Rodriguez-Sillke, Yasmina, Stoyanova, Ani K., Kreis, Martin E., Asbach, Patrick, Kunkel, Desiree, Priller, Josef, Anagnostopoulos, Ioannis, Kühl, Anja A., Miehle, Konstanze, Stumvoll, Michael, Tran, Florian, Fredrich, Broder, Forster, Michael, Franke, Andre, Bojarski, Christian, Glauben, Rainer, Löscher, Britt-Sabina, Siegmund, Britta, Weidinger, Carl
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 10.12.2019; Nature Publishing Group; Nature Portfolio
• Subjects: 13/31; 14/63; 38/23; 59/57; 692/163/2743/348; 692/4020/1503/257/1402; 82/51; 96/106; 96/21; 96/95; Cell Line; Colon; Crohn Disease - complications; Crohn Disease - pathology; Crohn's disease; Humanities and Social Sciences; Humans; Inflammation; Inflammation - drug therapy; Inflammatory bowel diseases; Intestine; Killer Cells, Natural; Leptin; Leptin - therapeutic use; Leukocytes; Lipodystrophy; Lipodystrophy, Congenital Generalized - complications; Male; multidisciplinary; Phenotype; Science; Science (multidisciplinary); T-Lymphocytes - cytology; Tumor Necrosis Factor-alpha - metabolism; Tumor necrosis factor-α; Wound Healing - drug effects

Leptin has been shown to modulate intestinal inflammation in mice. However, clinical evidence regarding its immune-stimulatory potential in human Crohn’s disease remains sparse. We here describe a patient with the unique combination of acquired generalized lipodystrophy and Crohn’s disease (AGLCD) f...