Specificity of the T Cell Response to Protein Biopharmaceuticals

• Published in: Frontiers in immunology Vol. 11; pp. 1550 - 14
• Main Authors: Meunier, Sylvain, de Bourayne, Marie, Hamze, Moustafa, Azam, Aurélien, Correia, Evelyne, Menier, Catherine, Maillère, Bernard
• Format: Journal Article Web Resource
• Language: English
• Published: Switzerland Frontiers 22.07.2020; Frontiers Media S.A
• Subjects: Animals; Antibodies; Antibodies - immunology; Antibodies, Monoclonal; Antibodies, Monoclonal - immunology; Biological Products; Biological Products - adverse effects; Biological Products - immunology; Biological Products - therapeutic use; biopharmaceuticals; Clonal Selection, Antigen-Mediated; Cytokines; Cytokines - metabolism; epitope; Epitopes, T-Lymphocyte; Epitopes, T-Lymphocyte - immunology; Factor VIII; Factor VIII - adverse effects; Factor VIII - therapeutic use; Human health sciences; Humans; immunogenicity; Immunologie & maladie infectieuse; Immunology; Immunology & infectious disease; Immunology and Allergy; Isoantigens; Isoantigens - immunology; Life Sciences; Proteins; Proteins - adverse effects; Proteins - immunology; Proteins - therapeutic use; Sciences de la santé humaine; T cell; T cell selection; T-Cell Antigen Receptor Specificity; T-Cell Antigen Receptor Specificity - immunology; T-Lymphocyte Subsets; T-Lymphocyte Subsets - immunology; T-Lymphocyte Subsets - metabolism; T-Lymphocytes; T-Lymphocytes - immunology; T-Lymphocytes - metabolism; therapeutic antibody; therapeutic protein; Thymus Gland; Thymus Gland - immunology; Thymus Gland - metabolism; tolerance; therapeutic protein; T cell; biopharmaceuticals; therapeutic antibody; epitope; T cell selection; immunogenicity; tolerance

The anti-drug antibody (ADA) response is an undesired humoral response raised against protein biopharmaceuticals (BPs) which can dramatically disturb their therapeutic properties. One particularity of the ADA response resides in the nature of the immunogens, which are usually human(ized) proteins an...