Circulating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitation

MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored. This case–control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart...

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Published in	International journal of cardiology Vol. 222; pp. 148 - 154
Main Authors	Chen, Mien-Cheng, Chang, Tzu-Hao, Chang, Jen-Ping, Huang, Hsien-Da, Ho, Wan-Chun, Lin, Yu-Sheng, Pan, Kuo-Li, Liu, Wen-Hao, Huang, Yao-Kuang
Format	Journal Article
Language	English
Published	Netherlands Elsevier B.V 01.11.2016
Subjects	Adult Aged Atrium Biomarkers - blood Cardiovascular Case-Control Studies Down-Regulation - genetics Female Gene Expression Profiling - methods Genes Genetic Markers Heart failure Heart Failure - etiology Heart Failure - genetics Humans Male MicroRNAs - blood Middle Aged Mitral regurgitation Mitral Valve Insufficiency - complications Mitral Valve Insufficiency - genetics Taiwan Heart failure Mitral regurgitation Atrium Genes
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ISSN	0167-5273 1874-1754
DOI	10.1016/j.ijcard.2016.07.179

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Abstract	MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored. This case–control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart failure. We used next generation sequencing to study the gene expression profiles in the sera, and quantitative RT-PCR to study serum and tissue miRs in the left atria. Next generation sequencing analysis and enrichment analysis showed that 25 miRs were differentially expressed in the sera of MR patients with heart failure compared to control subjects. The circulating miR-148b-3p (p=0.002) and miR-409-3p (p=0.010) were significantly down-regulated in the MR patients with heart failure compared to control subjects. However, only circulation miR-148b-3p was significantly down-regulated in the MR patients without heart failure compared to control subjects (p=0.009). The tissue miR-409-3p was significantly down-regulated in the MR patients with heart failure compared to 3 purchased normal controls (p=0.041). Notably, the tissue RASGRP3 mRNA, target gene of miR-409-3p, was significantly up-regulated in the MR patients with heart failure compared to normal controls (p=0.010). The tissue FRY (p=0.010) and GADD45A (p=0.010) mRNAs, target genes of miR-148b-3p, were significantly up-regulated in the MR patients with heart failure compared to normal controls. Circulating miR-148b-3p might serve as biomarker for future development of heart failure and miR-409-3p might serve as biomarker for incident heart failure in MR patients.
AbstractList	Abstract Background MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored. Methods This case–control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart failure. We used next generation sequencing to study the gene expression profiles in the sera, and quantitative RT-PCR to study serum and tissue miRs in the left atria. Results Next generation sequencing analysis and enrichment analysis showed that 25 miRs were differentially expressed in the sera of MR patients with heart failure compared to control subjects. The circulating miR-148b-3p (p = 0.002) and miR-409-3p (p = 0.010) were significantly down-regulated in the MR patients with heart failure compared to control subjects. However, only circulation miR-148b-3p was significantly down-regulated in the MR patients without heart failure compared to control subjects (p = 0.009). The tissue miR-409-3p was significantly down-regulated in the MR patients with heart failure compared to 3 purchased normal controls (p = 0.041). Notably, the tissue RASGRP3 mRNA, target gene of miR-409-3p, was significantly up-regulated in the MR patients with heart failure compared to normal controls (p = 0.010). The tissue FRY (p = 0.010) and GADD45A (p = 0.010) mRNAs, target genes of miR-148b-3p, were significantly up-regulated in the MR patients with heart failure compared to normal controls. Conclusions Circulating miR-148b-3p might serve as biomarker for future development of heart failure and miR-409-3p might serve as biomarker for incident heart failure in MR patients. BACKGROUNDMicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored.METHODSThis case-control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart failure. We used next generation sequencing to study the gene expression profiles in the sera, and quantitative RT-PCR to study serum and tissue miRs in the left atria.RESULTSNext generation sequencing analysis and enrichment analysis showed that 25 miRs were differentially expressed in the sera of MR patients with heart failure compared to control subjects. The circulating miR-148b-3p (p=0.002) and miR-409-3p (p=0.010) were significantly down-regulated in the MR patients with heart failure compared to control subjects. However, only circulation miR-148b-3p was significantly down-regulated in the MR patients without heart failure compared to control subjects (p=0.009). The tissue miR-409-3p was significantly down-regulated in the MR patients with heart failure compared to 3 purchased normal controls (p=0.041). Notably, the tissue RASGRP3 mRNA, target gene of miR-409-3p, was significantly up-regulated in the MR patients with heart failure compared to normal controls (p=0.010). The tissue FRY (p=0.010) and GADD45A (p=0.010) mRNAs, target genes of miR-148b-3p, were significantly up-regulated in the MR patients with heart failure compared to normal controls.CONCLUSIONSCirculating miR-148b-3p might serve as biomarker for future development of heart failure and miR-409-3p might serve as biomarker for incident heart failure in MR patients. MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain unexplored. This case-control study enrolled 32 MR patients with heart failure, 16 asymptomatic MR patients, and 12 control subjects without heart failure. We used next generation sequencing to study the gene expression profiles in the sera, and quantitative RT-PCR to study serum and tissue miRs in the left atria. Next generation sequencing analysis and enrichment analysis showed that 25 miRs were differentially expressed in the sera of MR patients with heart failure compared to control subjects. The circulating miR-148b-3p (p=0.002) and miR-409-3p (p=0.010) were significantly down-regulated in the MR patients with heart failure compared to control subjects. However, only circulation miR-148b-3p was significantly down-regulated in the MR patients without heart failure compared to control subjects (p=0.009). The tissue miR-409-3p was significantly down-regulated in the MR patients with heart failure compared to 3 purchased normal controls (p=0.041). Notably, the tissue RASGRP3 mRNA, target gene of miR-409-3p, was significantly up-regulated in the MR patients with heart failure compared to normal controls (p=0.010). The tissue FRY (p=0.010) and GADD45A (p=0.010) mRNAs, target genes of miR-148b-3p, were significantly up-regulated in the MR patients with heart failure compared to normal controls. Circulating miR-148b-3p might serve as biomarker for future development of heart failure and miR-409-3p might serve as biomarker for incident heart failure in MR patients.
Author	Liu, Wen-Hao Huang, Yao-Kuang Chang, Jen-Ping Chen, Mien-Cheng Huang, Hsien-Da Pan, Kuo-Li Ho, Wan-Chun Chang, Tzu-Hao Lin, Yu-Sheng
Author_xml	– sequence: 1 givenname: Mien-Cheng surname: Chen fullname: Chen, Mien-Cheng email: chenmien@ms76.hinet.net organization: Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan – sequence: 2 givenname: Tzu-Hao surname: Chang fullname: Chang, Tzu-Hao organization: Graduate Institute of Biomedical Informatics, Taipei Medical University, Taiwan – sequence: 3 givenname: Jen-Ping surname: Chang fullname: Chang, Jen-Ping organization: Division of Cardiovascular Surgery, Kaohsiung Chang Gung Memorial Hospital, Taiwan – sequence: 4 givenname: Hsien-Da surname: Huang fullname: Huang, Hsien-Da organization: Institute of Bioinformatics and Systems Biology, National Chiao Tung University, Taiwan – sequence: 5 givenname: Wan-Chun surname: Ho fullname: Ho, Wan-Chun organization: Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan – sequence: 6 givenname: Yu-Sheng surname: Lin fullname: Lin, Yu-Sheng organization: Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan – sequence: 7 givenname: Kuo-Li surname: Pan fullname: Pan, Kuo-Li organization: Division of Cardiology, Chang Gung Memorial Hospital, Chiayi, Taiwan – sequence: 8 givenname: Wen-Hao surname: Liu fullname: Liu, Wen-Hao organization: Division of Cardiology, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan – sequence: 9 givenname: Yao-Kuang surname: Huang fullname: Huang, Yao-Kuang organization: Department of Thoracic and Cardiovascular Surgery, Chang Gung Memorial Hospital, Chiayi, Taiwan
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Cites_doi	10.1038/nrg3074 10.1016/j.ijcard.2009.06.012 10.2217/fca.14.64 10.1093/nar/gkq1027 10.1158/1535-7163.MCT-12-0534-T 10.1093/nar/gku1215 10.1007/s13277-015-3777-4 10.2174/157016112801784611 10.1182/blood-2010-02-268011 10.1186/gb-2010-11-8-r86 10.1161/CIRCRESAHA.110.218297 10.1093/eurjhf/hfr155 10.18632/oncotarget.2014 10.1016/j.trsl.2014.11.005 10.1126/science.1139089 10.1136/heart.89.1.100 10.1093/nar/gkn851 10.1111/j.1540-8167.2011.02187.x 10.1093/nar/gkr688 10.1053/euhj.2002.3320 10.1016/j.jjcc.2011.01.009 10.1016/j.cell.2004.12.035 10.1248/bpb.b12-00578 10.1371/journal.pone.0003148
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References	Gatsiou, Boeckel, Randriamboavonjy, Stellos (bb0110) 2012; 10 Zhao, Zhang, Liu, Qin, Wang, Tian (bb0120) 2013; 12 Goecks, Nekrutenko, Taylor (bb0045) 2010; 11 Friedländer, Mackowiak, Li, Chen, Rajewsky (bb0050) 2012; 40 Danesh, Lewington, Thompson, Lowe, Collins, Kostis (bb0105) 2005; 294 Kozomara, Griffiths-Jones (bb0055) 2011; 39 Iung, Gohlke-Bärwolf, Tornos, Tribouilloy, Hall, Butchart (bb0005) 2002; 23 Shen, Hu, Schrauder, Yan, Wang, Medico (bb0115) 2014; 5 Tijsen, Creemers, Moerland, de Windt, van der Wal, Kok (bb0085) 2010; 106 Ziari, Zarea, Gity, Fayyaz, Yahaghi, Darian (bb0125) 2016; 37 Katz, Fargnoli, Williams, Kendle, Steuerwald, Bridges (bb0040) 2014; 10 Chang, Chen, Lin, Liu, Chen, Chen (bb0020) 2011; 146 van Rooij, Sutherland, Qi, Richardson, Hill, Olson (bb0030) 2007; 316 Gilad, Meiri, Yogev, Benjamin, Lebanony, Yerushalmi (bb0080) 2008; 3 Chen, Chang, Chang, Hsu, Huang, Ho, W (bb0025) 2015; 165 Funahashi, Izawa, Hirashiki, Cheng, Inden, Nomura (bb0075) 2011; 57 Ge, Li, Hu, Li, Jin, Gao (bb0130) 2015; 8 Esteller (bb0035) 2011; 12 Vlachos, Paraskevopoulou, Karagkouni, Georgakilas, Vergoulis, Kanellos (bb0060) 2015; 43 Lewis, Burge, Bartel (bb0070) 2005; 120 Fort, Borel, Migliavacca, Antonarakis, Fish, Neerman-Arbez (bb0100) 2010; 116 Goren, Kushnir, Zafrir, Tabak, Lewis, Amir (bb0095) 2012; 14 Corradi, Callegari, Maestri, Ferrara, Mangieri, Alinovi (bb0015) 2012; 23 Xiao, Zuo, Cai, Kang, Gao, Li (bb0065) 2009; 37 Endo, Naito, Ji, Nakanishi, Noguchi, Goto (bb0090) 2013; 36 Otto (bb0010) 2003; 89 Zhao (10.1016/j.ijcard.2016.07.179_bb0120) 2013; 12 Chang (10.1016/j.ijcard.2016.07.179_bb0020) 2011; 146 Vlachos (10.1016/j.ijcard.2016.07.179_bb0060) 2015; 43 Tijsen (10.1016/j.ijcard.2016.07.179_bb0085) 2010; 106 Danesh (10.1016/j.ijcard.2016.07.179_bb0105) 2005; 294 Kozomara (10.1016/j.ijcard.2016.07.179_bb0055) 2011; 39 Iung (10.1016/j.ijcard.2016.07.179_bb0005) 2002; 23 Ziari (10.1016/j.ijcard.2016.07.179_bb0125) 2016; 37 Goren (10.1016/j.ijcard.2016.07.179_bb0095) 2012; 14 Otto (10.1016/j.ijcard.2016.07.179_bb0010) 2003; 89 Gilad (10.1016/j.ijcard.2016.07.179_bb0080) 2008; 3 Funahashi (10.1016/j.ijcard.2016.07.179_bb0075) 2011; 57 Gatsiou (10.1016/j.ijcard.2016.07.179_bb0110) 2012; 10 van Rooij (10.1016/j.ijcard.2016.07.179_bb0030) 2007; 316 Xiao (10.1016/j.ijcard.2016.07.179_bb0065) 2009; 37 Friedländer (10.1016/j.ijcard.2016.07.179_bb0050) 2012; 40 Lewis (10.1016/j.ijcard.2016.07.179_bb0070) 2005; 120 Esteller (10.1016/j.ijcard.2016.07.179_bb0035) 2011; 12 Ge (10.1016/j.ijcard.2016.07.179_bb0130) 2015; 8 Corradi (10.1016/j.ijcard.2016.07.179_bb0015) 2012; 23 Chen (10.1016/j.ijcard.2016.07.179_bb0025) 2015; 165 Fort (10.1016/j.ijcard.2016.07.179_bb0100) 2010; 116 Katz (10.1016/j.ijcard.2016.07.179_bb0040) 2014; 10 Shen (10.1016/j.ijcard.2016.07.179_bb0115) 2014; 5 Goecks (10.1016/j.ijcard.2016.07.179_bb0045) 2010; 11 Endo (10.1016/j.ijcard.2016.07.179_bb0090) 2013; 36
References_xml	– volume: 165 start-page: 599 year: 2015 end-page: 620 ident: bb0025 article-title: Unraveling regulatory mechanisms of atrial remodeling of mitral regurgitation pigs by gene expression profiling analysis: role of type I angiotensin II receptor antagonist publication-title: Transl. Res. – volume: 3 start-page: e3148 year: 2008 ident: bb0080 article-title: Serum microRNAs are promising novel biomarkers publication-title: PLoS One – volume: 39 start-page: D152 year: 2011 end-page: D157 ident: bb0055 article-title: miRBase: integrating microRNA annotation and deep-sequencing data publication-title: Nucleic Acids Res. – volume: 12 start-page: 861 year: 2011 end-page: 874 ident: bb0035 article-title: Non-coding RNAs in human disease publication-title: Nat. Rev. Genet. – volume: 11 start-page: R86 year: 2010 ident: bb0045 article-title: Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences publication-title: Genome Biol. – volume: 36 start-page: 48 year: 2013 end-page: 54 ident: bb0090 article-title: MicroRNA 210 as a biomarker for congestive heart failure publication-title: Biol. Pharm. Bull. – volume: 23 start-page: 1253 year: 2002 end-page: 1266 ident: bb0005 article-title: Working Group on Valvular Heart Disease. Recommendations on the management of the asymptomatic patient with valvular heart disease publication-title: Eur. Heart J. – volume: 146 start-page: 44 year: 2011 end-page: 50 ident: bb0020 article-title: DNA repair in TUNEL-positive atrial cardiomyocytes of mitral and tricuspid valve diseases: potential mechanism for preserving cardiomyocytes publication-title: Int. J. Cardiol. – volume: 12 start-page: 83 year: 2013 end-page: 93 ident: bb0120 article-title: miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1 publication-title: Mol. Cancer Ther. – volume: 23 start-page: 271 year: 2012 end-page: 279 ident: bb0015 article-title: Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study publication-title: J. Cardiovasc. Electrophysiol. – volume: 10 start-page: 789 year: 2014 end-page: 800 ident: bb0040 article-title: MiRNAs as potential molecular targets in heart failure publication-title: Futur. Cardiol. – volume: 294 start-page: 1799 year: 2005 end-page: 1809 ident: bb0105 article-title: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis publication-title: JAMA – volume: 5 start-page: 5284 year: 2014 end-page: 5294 ident: bb0115 article-title: Circulating miR-148b and miR-133a as biomarkers for breast cancer detection publication-title: Oncotarget – volume: 89 start-page: 100 year: 2003 end-page: 105 ident: bb0010 article-title: Timing of surgery in mitral regurgitation publication-title: Heart – volume: 40 start-page: 37 year: 2012 end-page: 52 ident: bb0050 article-title: miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades publication-title: Nucleic Acids Res. – volume: 37 start-page: D105 year: 2009 end-page: D110 ident: bb0065 article-title: miRecords: an integrated resource for microRNA-target interactions publication-title: Nucleic Acids Res. – volume: 57 start-page: 338 year: 2011 end-page: 344 ident: bb0075 article-title: Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure publication-title: J. Cardiol. – volume: 43 start-page: D153 year: 2015 end-page: D159 ident: bb0060 article-title: DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions publication-title: Nucleic Acids Res. – volume: 116 start-page: 2608 year: 2010 end-page: 2615 ident: bb0100 article-title: Regulation of fibrinogen production by microRNAs publication-title: Blood – volume: 10 start-page: 524 year: 2012 end-page: 531 ident: bb0110 article-title: MicroRNAs in platelet biogenesis and function: implications in vascular homeostasis and inflammation publication-title: Curr. Vasc. Pharmacol. – volume: 316 start-page: 575 year: 2007 end-page: 579 ident: bb0030 article-title: Control of stress-dependent cardiac growth and gene expression by a microRNA publication-title: Science – volume: 14 start-page: 147 year: 2012 end-page: 154 ident: bb0095 article-title: Serum levels of microRNAs in patients with heart failure publication-title: Eur. J. Heart Fail. – volume: 106 start-page: 1035 year: 2010 end-page: 1039 ident: bb0085 article-title: MiR423-5p as a circulating biomarker for heart failure publication-title: Circ. Res. – volume: 8 start-page: 800 year: 2015 end-page: 805 ident: bb0130 article-title: MicroRNA-148b is down-regulated in non-small cell lung cancer and associated with poor survival publication-title: Int. J. Clin. Exp. Pathol. – volume: 120 start-page: 15 year: 2005 end-page: 20 ident: bb0070 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell – volume: 37 start-page: 5765 year: 2016 end-page: 5768 ident: bb0125 article-title: Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker publication-title: Tumour Biol. – volume: 12 start-page: 861 year: 2011 ident: 10.1016/j.ijcard.2016.07.179_bb0035 article-title: Non-coding RNAs in human disease publication-title: Nat. Rev. Genet. doi: 10.1038/nrg3074 – volume: 146 start-page: 44 year: 2011 ident: 10.1016/j.ijcard.2016.07.179_bb0020 article-title: DNA repair in TUNEL-positive atrial cardiomyocytes of mitral and tricuspid valve diseases: potential mechanism for preserving cardiomyocytes publication-title: Int. J. Cardiol. doi: 10.1016/j.ijcard.2009.06.012 – volume: 8 start-page: 800 year: 2015 ident: 10.1016/j.ijcard.2016.07.179_bb0130 article-title: MicroRNA-148b is down-regulated in non-small cell lung cancer and associated with poor survival publication-title: Int. J. Clin. Exp. Pathol. – volume: 10 start-page: 789 year: 2014 ident: 10.1016/j.ijcard.2016.07.179_bb0040 article-title: MiRNAs as potential molecular targets in heart failure publication-title: Futur. Cardiol. doi: 10.2217/fca.14.64 – volume: 39 start-page: D152 year: 2011 ident: 10.1016/j.ijcard.2016.07.179_bb0055 article-title: miRBase: integrating microRNA annotation and deep-sequencing data publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq1027 – volume: 12 start-page: 83 year: 2013 ident: 10.1016/j.ijcard.2016.07.179_bb0120 article-title: miR-148b functions as a tumor suppressor in pancreatic cancer by targeting AMPKα1 publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-12-0534-T – volume: 43 start-page: D153 year: 2015 ident: 10.1016/j.ijcard.2016.07.179_bb0060 article-title: DIANA-TarBase v7.0: indexing more than half a million experimentally supported miRNA:mRNA interactions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gku1215 – volume: 294 start-page: 1799 year: 2005 ident: 10.1016/j.ijcard.2016.07.179_bb0105 article-title: Plasma fibrinogen level and the risk of major cardiovascular diseases and nonvascular mortality: an individual participant meta-analysis publication-title: JAMA – volume: 37 start-page: 5765 year: 2016 ident: 10.1016/j.ijcard.2016.07.179_bb0125 article-title: Downregulation of miR-148b as biomarker for early detection of hepatocellular carcinoma and may serve as a prognostic marker publication-title: Tumour Biol. doi: 10.1007/s13277-015-3777-4 – volume: 10 start-page: 524 year: 2012 ident: 10.1016/j.ijcard.2016.07.179_bb0110 article-title: MicroRNAs in platelet biogenesis and function: implications in vascular homeostasis and inflammation publication-title: Curr. Vasc. Pharmacol. doi: 10.2174/157016112801784611 – volume: 116 start-page: 2608 year: 2010 ident: 10.1016/j.ijcard.2016.07.179_bb0100 article-title: Regulation of fibrinogen production by microRNAs publication-title: Blood doi: 10.1182/blood-2010-02-268011 – volume: 11 start-page: R86 year: 2010 ident: 10.1016/j.ijcard.2016.07.179_bb0045 article-title: Galaxy: a comprehensive approach for supporting accessible, reproducible, and transparent computational research in the life sciences publication-title: Genome Biol. doi: 10.1186/gb-2010-11-8-r86 – volume: 106 start-page: 1035 year: 2010 ident: 10.1016/j.ijcard.2016.07.179_bb0085 article-title: MiR423-5p as a circulating biomarker for heart failure publication-title: Circ. Res. doi: 10.1161/CIRCRESAHA.110.218297 – volume: 14 start-page: 147 year: 2012 ident: 10.1016/j.ijcard.2016.07.179_bb0095 article-title: Serum levels of microRNAs in patients with heart failure publication-title: Eur. J. Heart Fail. doi: 10.1093/eurjhf/hfr155 – volume: 5 start-page: 5284 year: 2014 ident: 10.1016/j.ijcard.2016.07.179_bb0115 article-title: Circulating miR-148b and miR-133a as biomarkers for breast cancer detection publication-title: Oncotarget doi: 10.18632/oncotarget.2014 – volume: 165 start-page: 599 year: 2015 ident: 10.1016/j.ijcard.2016.07.179_bb0025 article-title: Unraveling regulatory mechanisms of atrial remodeling of mitral regurgitation pigs by gene expression profiling analysis: role of type I angiotensin II receptor antagonist publication-title: Transl. Res. doi: 10.1016/j.trsl.2014.11.005 – volume: 316 start-page: 575 year: 2007 ident: 10.1016/j.ijcard.2016.07.179_bb0030 article-title: Control of stress-dependent cardiac growth and gene expression by a microRNA publication-title: Science doi: 10.1126/science.1139089 – volume: 89 start-page: 100 year: 2003 ident: 10.1016/j.ijcard.2016.07.179_bb0010 article-title: Timing of surgery in mitral regurgitation publication-title: Heart doi: 10.1136/heart.89.1.100 – volume: 37 start-page: D105 year: 2009 ident: 10.1016/j.ijcard.2016.07.179_bb0065 article-title: miRecords: an integrated resource for microRNA-target interactions publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkn851 – volume: 23 start-page: 271 year: 2012 ident: 10.1016/j.ijcard.2016.07.179_bb0015 article-title: Differential structural remodeling of the left-atrial posterior wall in patients affected by mitral regurgitation with or without persistent atrial fibrillation: a morphological and molecular study publication-title: J. Cardiovasc. Electrophysiol. doi: 10.1111/j.1540-8167.2011.02187.x – volume: 40 start-page: 37 year: 2012 ident: 10.1016/j.ijcard.2016.07.179_bb0050 article-title: miRDeep2 accurately identifies known and hundreds of novel microRNA genes in seven animal clades publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr688 – volume: 23 start-page: 1253 year: 2002 ident: 10.1016/j.ijcard.2016.07.179_bb0005 article-title: Working Group on Valvular Heart Disease. Recommendations on the management of the asymptomatic patient with valvular heart disease publication-title: Eur. Heart J. doi: 10.1053/euhj.2002.3320 – volume: 57 start-page: 338 year: 2011 ident: 10.1016/j.ijcard.2016.07.179_bb0075 article-title: Altered microRNA expression associated with reduced catecholamine sensitivity in patients with chronic heart failure publication-title: J. Cardiol. doi: 10.1016/j.jjcc.2011.01.009 – volume: 120 start-page: 15 year: 2005 ident: 10.1016/j.ijcard.2016.07.179_bb0070 article-title: Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets publication-title: Cell doi: 10.1016/j.cell.2004.12.035 – volume: 36 start-page: 48 year: 2013 ident: 10.1016/j.ijcard.2016.07.179_bb0090 article-title: MicroRNA 210 as a biomarker for congestive heart failure publication-title: Biol. Pharm. Bull. doi: 10.1248/bpb.b12-00578 – volume: 3 start-page: e3148 year: 2008 ident: 10.1016/j.ijcard.2016.07.179_bb0080 article-title: Serum microRNAs are promising novel biomarkers publication-title: PLoS One doi: 10.1371/journal.pone.0003148
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Snippet	MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR) remain... Abstract Background MicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation... BACKGROUNDMicroRNAs (miRs) regulate gene expression in heart failure. Circulating miRs as biomarkers for heart failure in mitral regurgitation patients (MR)...
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SubjectTerms	Adult Aged Atrium Biomarkers - blood Cardiovascular Case-Control Studies Down-Regulation - genetics Female Gene Expression Profiling - methods Genes Genetic Markers Heart failure Heart Failure - etiology Heart Failure - genetics Humans Male MicroRNAs - blood Middle Aged Mitral regurgitation Mitral Valve Insufficiency - complications Mitral Valve Insufficiency - genetics Taiwan
Title	Circulating miR-148b-3p and miR-409-3p as biomarkers for heart failure in patients with mitral regurgitation
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