The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

• Published in: Nature communications Vol. 13; no. 1; pp. 6081 - 19
• Main Authors: Zhou, Wei, Wu, Wen-hui, Si, Zi-lin, Liu, Hui-ling, Wang, Hanyu, Jiang, Hong, Liu, Ya-fang, Alolga, Raphael N., Chen, Cheng, Liu, Shi-jia, Bian, Xue-yan, Shan, Jin-jun, Li, Jing, Tan, Ning-hua, Zhang, Zhi-hao
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 14.10.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 38/77; 631/326/2565/2134; 64/60; 692/699/1585/3182; 82/58; Adenine; Adenine - metabolism; Animal models; Animals; Attenuation; Bacteroides fragilis; Biological Products - metabolism; Disease Models, Animal; Fibrosis; Gastrointestinal Microbiome; Humanities and Social Sciences; Inflammation; Kidney - metabolism; Kidney diseases; Kidney Diseases - pathology; Kidneys; Lipopolysaccharides; Lipopolysaccharides - metabolism; Lipopolysaccharides - toxicity; Metabolomics; Mice; Microorganisms; multidisciplinary; Natural products; Oral administration; Oxidation; Oxidative stress; Proteomics; Reabsorption; Renal Insufficiency, Chronic - pathology; Science; Science (multidisciplinary); Sodium-Glucose Transporter 2 - metabolism; Substrates; Ureteral Obstruction - metabolism

Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis ( B. fragilis ) in renal...