The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice

Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis ( B. fragilis ) in renal...

Full description

Saved in:
Bibliographic Details
Published inNature communications Vol. 13; no. 1; pp. 6081 - 19
Main Authors Zhou, Wei, Wu, Wen-hui, Si, Zi-lin, Liu, Hui-ling, Wang, Hanyu, Jiang, Hong, Liu, Ya-fang, Alolga, Raphael N., Chen, Cheng, Liu, Shi-jia, Bian, Xue-yan, Shan, Jin-jun, Li, Jing, Tan, Ning-hua, Zhang, Zhi-hao
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 14.10.2022
Nature Publishing Group
Nature Portfolio
Subjects
13
38/77
631/326/2565/2134
64/60
692/699/1585/3182
82/58
Adenine
Adenine - metabolism
Animal models
Animals
Attenuation
Bacteroides fragilis
Biological Products - metabolism
Disease Models, Animal
Fibrosis
Gastrointestinal Microbiome
Humanities and Social Sciences
Inflammation
Kidney - metabolism
Kidney diseases
Kidney Diseases - pathology
Kidneys
Lipopolysaccharides
Lipopolysaccharides - metabolism
Lipopolysaccharides - toxicity
Metabolomics
Mice
Microorganisms
multidisciplinary
Natural products
Oral administration
Oxidation
Oxidative stress
Proteomics
Reabsorption
Renal Insufficiency, Chronic - pathology
Science
Science (multidisciplinary)
Sodium-Glucose Transporter 2 - metabolism
Substrates
Ureteral Obstruction - metabolism
Online AccessGet full text

Cover

Abstract Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis ( B. fragilis ) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels. Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.
AbstractList Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis ( B. fragilis ) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels. Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.
Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis ( B. fragilis ) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels.
Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis (B. fragilis) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels.Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.
Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis (B. fragilis) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels.Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis (B. fragilis) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels.
Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via the upregulation of SGLT2, which contributes to renal reabsorption of 1,5-AG, and that 1,5-AG improves renal fibrosis via inhibition of oxidative stress and inflammation.
Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen against renal fibrosis can therefore not be overemphasized. Here we show a novel protective role of Bacteroides fragilis (B. fragilis) in renal fibrosis in mice. We demonstrate decreased abundance of B. fragilis in the feces of CKD patients and unilateral ureteral obstruction (UUO) mice. Oral administration of live B. fragilis attenuates renal fibrosis in UUO and adenine mice models. Increased lipopolysaccharide (LPS) levels are decreased after B. fragilis administration. Results of metabolomics and proteomics studies show decreased level of 1,5-anhydroglucitol (1,5-AG), a substrate of SGLT2, which increases after B. fragilis administration via enhancement of renal SGLT2 expression. 1,5-AG is an agonist of TGR5 that attenuates renal fibrosis by inhibiting oxidative stress and inflammation. Madecassoside, a natural product found via in vitro screening promotes B. fragilis growth and remarkably ameliorates renal fibrosis. Our findings reveal the ameliorative role of B. fragilis in renal fibrosis via decreasing LPS and increasing 1,5-AG levels.
ArticleNumber 6081
Author Liu, Shi-jia
Wang, Hanyu
Zhang, Zhi-hao
Jiang, Hong
Li, Jing
Zhou, Wei
Shan, Jin-jun
Bian, Xue-yan
Liu, Hui-ling
Wu, Wen-hui
Tan, Ning-hua
Si, Zi-lin
Liu, Ya-fang
Chen, Cheng
Alolga, Raphael N.
Author_xml – sequence: 1
  givenname: Wei
  orcidid: 0000-0001-5486-4849
  surname: Zhou
  fullname: Zhou, Wei
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 2
  givenname: Wen-hui
  orcidid: 0000-0002-0336-6011
  surname: Wu
  fullname: Wu, Wen-hui
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 3
  givenname: Zi-lin
  surname: Si
  fullname: Si, Zi-lin
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 4
  givenname: Hui-ling
  surname: Liu
  fullname: Liu, Hui-ling
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 5
  givenname: Hanyu
  surname: Wang
  fullname: Wang, Hanyu
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 6
  givenname: Hong
  surname: Jiang
  fullname: Jiang, Hong
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 7
  givenname: Ya-fang
  surname: Liu
  fullname: Liu, Ya-fang
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 8
  givenname: Raphael N.
  surname: Alolga
  fullname: Alolga, Raphael N.
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 9
  givenname: Cheng
  surname: Chen
  fullname: Chen, Cheng
  organization: Department of Nephrology, Renmin Hospital of Wuhan University
– sequence: 10
  givenname: Shi-jia
  surname: Liu
  fullname: Liu, Shi-jia
  organization: Affiliated Hospital of Nanjing University of Chinese Medicine
– sequence: 11
  givenname: Xue-yan
  surname: Bian
  fullname: Bian, Xue-yan
  organization: Ningbo Hospital of Zhejiang University
– sequence: 12
  givenname: Jin-jun
  surname: Shan
  fullname: Shan, Jin-jun
  organization: Medical Metabolomics Center, Nanjing University of Chinese Medicine
– sequence: 13
  givenname: Jing
  orcidid: 0000-0001-9972-7397
  surname: Li
  fullname: Li, Jing
  organization: School of Life Science and Technology, China Pharmaceutical University
– sequence: 14
  givenname: Ning-hua
  surname: Tan
  fullname: Tan, Ning-hua
  email: nhtan@cpu.edu.cn
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
– sequence: 15
  givenname: Zhi-hao
  orcidid: 0000-0002-5152-0511
  surname: Zhang
  fullname: Zhang, Zhi-hao
  email: zzh-198518@163.com
  organization: State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36241632$$D View this record in MEDLINE/PubMed
BookMark eNp9UstO3TAUtBAVUMoPdFFF6qabtH7FTjaVCgKKhNQNXVt-HAdfJTG1EyT-vr430AILvLF1zsxo5Jn3aH-KEyD0keCvBLP2W-aEC1ljSmvGWsprsYeOKOakJpKy_WfvQ3SS8waXwzrScn6ADpmgnAhGj9DlzS1U_TJXY7ApGqhOtZ0hxeAgVz7pPgwhV3qEIcSk5zJMMOmh8sGkmMsqTFsqfEDvvB4ynDzex-j3xfnN2c_6-tfl1dmP69o2HM-1ccJ1WkgqhZVeSu077BviDG-pdmA0BykEx05ig7HhXAhiiYUCddh2jh2jq1XXRb1RdymMOj2oqIPaDWLqlU5zsAMoaVovJDjSdIybFuvWe9Nxb2WnsbNN0fq-at0tZgRnYZqTHl6IvtxM4Vb18V51jWgbJovAl0eBFP8skGc1hmxhGPQEccmKStqUGEo6Bfr5FXQTl1R-cofishOYbgU_PXf0z8pTXgXQroASVs4JvLJh1nOIW4NhUASrbTvU2g5V2qF27VCiUOkr6pP6myS2knIBTz2k_7bfYP0F5hLMOg
CitedBy_id crossref_primary_10_1097_IMNA_D_23_00017
crossref_primary_10_1039_D3FO05671F
crossref_primary_10_1093_ckj_sfad303
crossref_primary_10_3390_app13053212
crossref_primary_10_1016_j_biopha_2023_115434
crossref_primary_10_1016_j_phymed_2024_156223
crossref_primary_10_1016_j_ijbiomac_2024_136492
crossref_primary_10_1016_j_phymed_2024_155372
crossref_primary_10_1097_TP_0000000000004485
crossref_primary_10_14336_AD_2023_0309
crossref_primary_10_1016_j_micres_2024_127796
crossref_primary_10_1021_acs_est_4c10724
crossref_primary_10_3389_fphar_2024_1456721
crossref_primary_10_1016_j_ijbiomac_2024_138629
crossref_primary_10_1097_IMNA_D_23_00012
crossref_primary_10_1111_jog_16236
crossref_primary_10_3390_nu15194198
crossref_primary_10_1016_j_jprot_2024_105355
crossref_primary_10_22246_jikm_2024_45_4_568
crossref_primary_10_1016_j_isci_2023_105991
crossref_primary_10_1089_met_2024_0030
crossref_primary_10_1016_j_ijbiomac_2024_134216
crossref_primary_10_1016_j_phymed_2024_156335
crossref_primary_10_1016_j_neuropharm_2023_109812
crossref_primary_10_1186_s40659_023_00431_8
crossref_primary_10_1016_j_foodres_2024_114322
crossref_primary_10_2147_IJNRD_S489074
crossref_primary_10_1007_s00018_024_05532_5
crossref_primary_10_1016_j_celrep_2023_112851
crossref_primary_10_3389_fcimb_2024_1523708
crossref_primary_10_1002_imt2_270
crossref_primary_10_1038_s41421_024_00709_5
crossref_primary_10_1038_s43705_023_00332_7
crossref_primary_10_23876_j_krcp_23_156
crossref_primary_10_3389_fcimb_2024_1363276
crossref_primary_10_1038_s42003_023_05581_9
crossref_primary_10_1039_D4FO03731F
crossref_primary_10_1021_acs_jafc_4c02591
crossref_primary_10_1016_j_jff_2023_105469
crossref_primary_10_1002_advs_202307850
crossref_primary_10_1186_s40168_023_01734_4
crossref_primary_10_1002_advs_202406936
crossref_primary_10_1002_adma_202412783
crossref_primary_10_1038_s41598_024_59250_w
crossref_primary_10_37349_edd_2023_00029
crossref_primary_10_1039_D3FO02110F
crossref_primary_10_1016_j_lfs_2024_123072
crossref_primary_10_1186_s12951_024_02586_2
crossref_primary_10_1016_j_celrep_2024_114830
Cites_doi 10.1038/nature08821
10.1038/nm.4358
10.1073/pnas.0400035101
10.1093/glycob/cwu117
10.1038/s41401-019-0319-4
10.1038/ki.2011.380
10.1002/hep.24525
10.1038/ismej.2015.131
10.1016/j.phymed.2019.153111
10.1053/j.ajkd.2014.01.416
10.1007/s10753-020-01382-y
10.2215/CJN.11971113
10.1128/am.27.5.961-979.1974
10.1136/bmj.k2179
10.1016/j.jep.2013.09.004
10.2337/dc12-0787
10.3389/fimmu.2020.609060
10.1038/s41586-021-03828-1
10.1038/srep22474
10.1016/j.phrs.2016.05.035
10.1038/nmeth.2834
10.1038/s41598-017-16635-4
10.1038/srep22151
10.1016/j.jpba.2020.113262
10.1038/nature07008
10.1373/clinchem.2012.188367
10.1111/bph.13421
10.1002/jcc.20290
10.1053/j.ajkd.2015.09.027
10.1146/annurev-physiol-022516-034227
10.1248/bpb.29.2432
10.3109/10715762.2013.779373
10.1681/ASN.2014121271
10.3390/toxins10070300
10.1126/science.8211161
10.1016/j.bbadis.2017.08.021
10.1038/s41581-018-0018-2
10.1038/srep18314
10.1126/science.abd8344
10.1016/j.jhep.2010.12.004
10.1038/mi.2010.29
10.1038/s41440-018-0144-z
10.1016/j.cell.2013.11.024
10.1038/ncomms8489
10.2133/dmpk.19.41
10.1002/ptr.5120
10.1161/HYPERTENSIONAHA.119.13079
10.1007/s00018-019-03155-9
10.1038/ki.2012.345
10.1128/mBio.02566-18
10.1016/j.cell.2005.05.007
10.1093/aje/kwx167
10.1007/s11306-020-1642-y
10.1007/978-1-4757-3230-6_13
10.1038/sj.onc.1209943
10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B
10.1016/S0140-6736(13)60687-X
10.1681/ASN.2013080905
10.1021/pr1002214
10.1126/science.1206095
10.2337/diab.38.6.723
10.4049/jimmunol.1001443
10.2337/dc11-1462
10.1053/j.gastro.2019.03.020
10.1073/pnas.0909122107
10.1038/s41401-022-00898-3
ContentType Journal Article
Copyright The Author(s) 2022
2022. The Author(s).
The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
Copyright_xml – notice: The Author(s) 2022
– notice: 2022. The Author(s).
– notice: The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
DBID C6C
AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7X7
7XB
88E
8AO
8FD
8FE
8FG
8FH
8FI
8FJ
8FK
ABUWG
AEUYN
AFKRA
ARAPS
AZQEC
BBNVY
BENPR
BGLVJ
BHPHI
C1K
CCPQU
DWQXO
FR3
FYUFA
GHDGH
GNUQQ
H94
HCIFZ
K9.
LK8
M0S
M1P
M7P
P5Z
P62
P64
PHGZM
PHGZT
PIMPY
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
PRINS
RC3
SOI
7X8
5PM
DOA
DOI 10.1038/s41467-022-33824-6
DatabaseName Springer Nature OA Free Journals
CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Calcium & Calcified Tissue Abstracts
Chemoreception Abstracts
Ecology Abstracts
Entomology Abstracts (Full archive)
Environment Abstracts
Immunology Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
Nucleic Acids Abstracts
Oncogenes and Growth Factors Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Technology Research Database
ProQuest SciTech Collection
ProQuest Technology Collection
ProQuest Natural Science Journals
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Biological Science Collection
ProQuest Central
Technology Collection
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One Community College
ProQuest Central
Engineering Research Database
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
AIDS and Cancer Research Abstracts
ProQuest SciTech Premium Collection
ProQuest Health & Medical Complete (Alumni)
Biological Sciences
ProQuest Health & Medical Collection
Proquest Medical Database
Biological Science Database
Advanced Technologies & Aerospace Collection
ProQuest Advanced Technologies & Aerospace Collection
Biotechnology and BioEngineering Abstracts
ProQuest Central Premium
ProQuest One Academic (New)
Publicly Available Content Database
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
ProQuest One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Applied & Life Sciences
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
Genetics Abstracts
Environment Abstracts
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Publicly Available Content Database
ProQuest Central Student
Oncogenes and Growth Factors Abstracts
ProQuest Advanced Technologies & Aerospace Collection
ProQuest Central Essentials
Nucleic Acids Abstracts
SciTech Premium Collection
ProQuest Central China
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
Chemoreception Abstracts
Industrial and Applied Microbiology Abstracts (Microbiology A)
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Advanced Technologies & Aerospace Collection
ProQuest Biological Science Collection
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
ProQuest Technology Collection
Health Research Premium Collection (Alumni)
Biological Science Database
Ecology Abstracts
ProQuest Hospital Collection (Alumni)
Biotechnology and BioEngineering Abstracts
Entomology Abstracts
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
Engineering Research Database
ProQuest One Academic
Calcium & Calcified Tissue Abstracts
ProQuest One Academic (New)
Technology Collection
Technology Research Database
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Central
ProQuest Health & Medical Research Collection
Genetics Abstracts
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
AIDS and Cancer Research Abstracts
ProQuest SciTech Collection
Advanced Technologies & Aerospace Database
ProQuest Medical Library
Immunology Abstracts
Environment Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
CrossRef

Publicly Available Content Database
MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: C6C
  name: Springer Nature OA Free Journals
  url: http://www.springeropen.com/
  sourceTypes: Publisher
– sequence: 2
  dbid: DOA
  name: DOAJ Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 3
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 4
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 5
  dbid: 8FG
  name: ProQuest Technology Collection
  url: https://search.proquest.com/technologycollection1
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Biology
EISSN 2041-1723
EndPage 19
ExternalDocumentID oai_doaj_org_article_7b8f67ed15934b80a8ffb94fc79a0dc5
PMC9568537
36241632
10_1038_s41467_022_33824_6
Genre Research Support, Non-U.S. Gov't
Journal Article
GroupedDBID ---
0R~
39C
3V.
53G
5VS
70F
7X7
88E
8AO
8FE
8FG
8FH
8FI
8FJ
AAHBH
AAJSJ
ABUWG
ACGFO
ACGFS
ACIWK
ACMJI
ACPRK
ACSMW
ADBBV
ADFRT
ADMLS
ADRAZ
AENEX
AEUYN
AFKRA
AFRAH
AHMBA
AJTQC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
AMTXH
AOIJS
ARAPS
ASPBG
AVWKF
AZFZN
BBNVY
BCNDV
BENPR
BGLVJ
BHPHI
BPHCQ
BVXVI
C6C
CCPQU
DIK
EBLON
EBS
EE.
EMOBN
F5P
FEDTE
FYUFA
GROUPED_DOAJ
HCIFZ
HMCUK
HVGLF
HYE
HZ~
KQ8
LK8
M1P
M48
M7P
M~E
NAO
O9-
OK1
P2P
P62
PIMPY
PQQKQ
PROAC
PSQYO
RNS
RNT
RNTTT
RPM
SNYQT
SV3
TSG
UKHRP
AASML
AAYXX
CITATION
PHGZM
PHGZT
CGR
CUY
CVF
ECM
EIF
NPM
PJZUB
PPXIY
PQGLB
7QL
7QP
7QR
7SN
7SS
7ST
7T5
7T7
7TM
7TO
7XB
8FD
8FK
AARCD
AZQEC
C1K
DWQXO
FR3
GNUQQ
H94
K9.
P64
PKEHL
PQEST
PQUKI
PRINS
RC3
SOI
7X8
5PM
PUEGO
ID FETCH-LOGICAL-c540t-bd6d9a67276c7f77af90f51db482adeba4e76640d70b00b44661c1cef77d0c9d3
IEDL.DBID C6C
ISSN 2041-1723
IngestDate Wed Aug 27 01:27:22 EDT 2025
Thu Aug 21 18:39:58 EDT 2025
Thu Jul 10 23:30:50 EDT 2025
Wed Aug 13 09:29:02 EDT 2025
Mon Jul 21 05:36:48 EDT 2025
Tue Jul 01 00:58:28 EDT 2025
Thu Apr 24 23:04:15 EDT 2025
Fri Feb 21 02:38:18 EST 2025
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 1
Language English
License 2022. The Author(s).
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c540t-bd6d9a67276c7f77af90f51db482adeba4e76640d70b00b44661c1cef77d0c9d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ORCID 0000-0001-9972-7397
0000-0002-5152-0511
0000-0001-5486-4849
0000-0002-0336-6011
OpenAccessLink https://www.nature.com/articles/s41467-022-33824-6
PMID 36241632
PQID 2724796027
PQPubID 546298
PageCount 19
ParticipantIDs doaj_primary_oai_doaj_org_article_7b8f67ed15934b80a8ffb94fc79a0dc5
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9568537
proquest_miscellaneous_2725204824
proquest_journals_2724796027
pubmed_primary_36241632
crossref_citationtrail_10_1038_s41467_022_33824_6
crossref_primary_10_1038_s41467_022_33824_6
springer_journals_10_1038_s41467_022_33824_6
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate 2022-10-14
PublicationDateYYYYMMDD 2022-10-14
PublicationDate_xml – month: 10
  year: 2022
  text: 2022-10-14
  day: 14
PublicationDecade 2020
PublicationPlace London
PublicationPlace_xml – name: London
– name: England
PublicationTitle Nature communications
PublicationTitleAbbrev Nat Commun
PublicationTitleAlternate Nat Commun
PublicationYear 2022
Publisher Nature Publishing Group UK
Nature Publishing Group
Nature Portfolio
Publisher_xml – name: Nature Publishing Group UK
– name: Nature Publishing Group
– name: Nature Portfolio
References Liu (CR24) 2017; 23
Wang (CR48) 2016; 27
Morris (CR69) 1998; 19
Zhou (CR31) 2016; 2
Juraschek, Steffes, Miller, Selvin (CR43) 2012; 35
Zhou (CR63) 2020; 185
Wang, Chen, Yu, Forman, Huang (CR49) 2011; 54
Cui (CR58) 2020; 66
Yamanouchi (CR42) 1989; 38
Turner, Bauer, Abramowitz, Melamed, Hostetter (CR5) 2012; 81
Kim (CR25) 2012; 35
Kulak, Pichler, Paron, Nagaraj, Mann (CR66) 2014; 11
Pluznick (CR6) 2020; 369
D’Argenio, Mazzacca (CR21) 1999; 472
Tunyasuvunakool (CR68) 2021; 596
Hashim (CR51) 2011; 18
Popolo (CR23) 2013; 47
Humphreys (CR3) 2018; 80
Moore We Fau, Holdeman, Holdeman (CR35) 1974; 27
Yamanouchi, Tachibana, Akanuma, Minoda, Akaoka (CR41) 1992; 263
Vaziri, Wong, Pahl, Piceno, Andersen (CR10) 2013; 83
Baxter (CR15) 2019; 10
Zhang (CR64) 2020; 16
Lu (CR55) 2014; 28
Round, Mazmanian (CR18) 2010; 107
Ramezani (CR14) 2016; 67
Park, Shin, Bae, Lee, Kim (CR32) 2006; 29
Ochoa-Repáraz (CR39) 2010; 185
Ochoa-Repáraz (CR36) 2010; 3
Qin (CR7) 2010; 464
Johnson, Jones, Cobb (CR20) 2015; 25
Nakamura, Masuda, Takahashi, Saito, Inui (CR46) 2004; 19
Rebholz Cm Fau (CR26) 2017; 186
Tzianabos, Onderdonk, Rosner, Cisneros, Kasper (CR16) 1993; 262
Pols, Noriega, Nomura, Auwerx, Schoonjans (CR27) 2011; 54
Li (CR65) 2019; 157
Yu (CR45) 2014; 9
Yang, Richards, Pepine, Raizada (CR9) 2018; 14
Zhang (CR62) 2016; 6
Chang (CR30) 2015; 23
Ramezani, Raj (CR34) 2013; 25
Inker (CR4) 2014; 63
Mazmanian, Round, Kasper, Kasper (CR17) 2008; 29
Castillo-Rodriguez (CR11) 2018; 10
Yang (CR28) 2016; 111
Zhuang (CR29) 2021; 44
Hayden, West, Ghosh (CR40) 2006; 25
Logue (CR59) 2016; 10
Feng (CR60) 2019; 76
Zhang, He, Zhao, Chen, Tan (CR22) 2020; 41
Juraschek, Steffes, Elizabeth (CR44) 2012; 58
Leng, Han, Rui, Dai, Xia (CR33) 2013; 150
Su, Ye, Qin, Ding (CR52) 2015; 5
Hsiao (CR19) 2013; 155
Humphreys (CR2) 2017; 7
Round (CR38) 2011; 332
Fukasawa (CR57) 2004; 101
Zhou, Hu, Tam (CR71) 2017; 7
Valdes, Walter, Segal, Spector (CR8) 2018; 361
Onal, Afsar, Covic, Vaziri, Kanbay (CR12) 2019; 42
Mazmanian (CR37) 2005; 122
Jha (CR1) 2013; 382
Salguero, Al-Obaide, Singh, Siepmann, Vasylyeva (CR13) 2019; 18
Wang (CR54) 2014; 12
Case (CR70) 2005; 26
Wiśniewski, Nagaraj, Zougman, Gnad, Mann (CR67) 2010; 9
CR61
Deutschmann (CR47) 2018; 1864
Marques (CR56) 2019; 74
Shi (CR50) 2020; 11
Xia (CR53) 2016; 173
JL Pluznick (33824_CR6) 2020; 369
MS Hayden (33824_CR40) 2006; 25
WJ Kim (33824_CR25) 2012; 35
SP Juraschek (33824_CR43) 2012; 35
DA Case (33824_CR70) 2005; 26
L Zhuang (33824_CR29) 2021; 44
J Ochoa-Repáraz (33824_CR39) 2010; 185
ND Vaziri (33824_CR10) 2013; 83
V Jha (33824_CR1) 2013; 382
JL Round (33824_CR38) 2011; 332
H Fukasawa (33824_CR57) 2004; 101
JL Johnson (33824_CR20) 2015; 25
TW Pols (33824_CR27) 2011; 54
LA Inker (33824_CR4) 2014; 63
W Zhou (33824_CR71) 2017; 7
GX Lu (33824_CR55) 2014; 28
SP Juraschek (33824_CR44) 2012; 58
K Deutschmann (33824_CR47) 2018; 1864
EM Onal (33824_CR12) 2019; 42
Moore We Fau (33824_CR35) 1974; 27
JR Wiśniewski (33824_CR67) 2010; 9
JM Turner (33824_CR5) 2012; 81
ZH Zhang (33824_CR22) 2020; 41
MV Salguero (33824_CR13) 2019; 18
J Qin (33824_CR7) 2010; 464
JB Logue (33824_CR59) 2016; 10
YD Wang (33824_CR49) 2011; 54
T Yang (33824_CR9) 2018; 14
W Zhou (33824_CR63) 2020; 185
E Castillo-Rodriguez (33824_CR11) 2018; 10
SK Mazmanian (33824_CR17) 2008; 29
P Hashim (33824_CR51) 2011; 18
GM Morris (33824_CR69) 1998; 19
Z Yang (33824_CR28) 2016; 111
D Cui (33824_CR58) 2020; 66
EK Park (33824_CR32) 2006; 29
AO Tzianabos (33824_CR16) 1993; 262
Z Su (33824_CR52) 2015; 5
Y Xia (33824_CR53) 2016; 173
J Li (33824_CR65) 2019; 157
JL Round (33824_CR18) 2010; 107
T Wang (33824_CR54) 2014; 12
G D’Argenio (33824_CR21) 1999; 472
BD Humphreys (33824_CR2) 2017; 7
DD Leng (33824_CR33) 2013; 150
Z Zhang (33824_CR64) 2020; 16
FZ Marques (33824_CR56) 2019; 74
NT Baxter (33824_CR15) 2019; 10
YL Feng (33824_CR60) 2019; 76
J Ochoa-Repáraz (33824_CR36) 2010; 3
A Popolo (33824_CR23) 2013; 47
N Nakamura (33824_CR46) 2004; 19
SK Mazmanian (33824_CR37) 2005; 122
R Liu (33824_CR24) 2017; 23
XX Wang (33824_CR48) 2016; 27
A Ramezani (33824_CR34) 2013; 25
T Yamanouchi (33824_CR41) 1992; 263
T Yamanouchi (33824_CR42) 1989; 38
B Yu (33824_CR45) 2014; 9
AM Valdes (33824_CR8) 2018; 361
A Ramezani (33824_CR14) 2016; 67
CJ Chang (33824_CR30) 2015; 23
ZH Zhang (33824_CR62) 2016; 6
Rebholz Cm Fau (33824_CR26) 2017; 186
NA Kulak (33824_CR66) 2014; 11
33824_CR61
K Tunyasuvunakool (33824_CR68) 2021; 596
SS Zhou (33824_CR31) 2016; 2
Y Shi (33824_CR50) 2020; 11
BD Humphreys (33824_CR3) 2018; 80
EY Hsiao (33824_CR19) 2013; 155
References_xml – volume: 464
  start-page: 59
  year: 2010
  end-page: 65
  ident: CR7
  article-title: A human gut microbial gene catalogue established by metagenomic sequencing
  publication-title: Nature
  doi: 10.1038/nature08821
– volume: 263
  start-page: E268
  year: 1992
  ident: CR41
  article-title: Origin and disposal of 1,5-anhydroglucitol, a major polyol in the human body
  publication-title: Am. J. Physiol.
– volume: 23
  start-page: 859
  year: 2017
  end-page: 868
  ident: CR24
  article-title: Gut microbiome and serum metabolome alterations in obesity and after weight-loss intervention
  publication-title: Nat. Med.
  doi: 10.1038/nm.4358
– volume: 101
  start-page: 8687
  year: 2004
  end-page: 8692
  ident: CR57
  article-title: Down-regulation of Smad7 expression by ubiquitin-dependent degradation contributes to renal fibrosis in obstructive nephropathy in mice
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0400035101
– volume: 25
  start-page: 368
  year: 2015
  end-page: 375
  ident: CR20
  article-title: Bacterial capsular polysaccharide prevents the onset of asthma through T-cell activation
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwu117
– volume: 41
  start-page: 373
  year: 2020
  end-page: 382
  ident: CR22
  article-title: Asiatic acid prevents renal fibrosis in UUO rats via promoting the production of 15d-PGJ2, an endogenous ligand of PPAR-γ
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/s41401-019-0319-4
– volume: 81
  start-page: 351
  year: 2012
  end-page: 362
  ident: CR5
  article-title: Treatment of chronic kidney disease
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.380
– volume: 54
  start-page: 1421
  year: 2011
  end-page: 1432
  ident: CR49
  article-title: The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice
  publication-title: Hepatology
  doi: 10.1002/hep.24525
– volume: 10
  start-page: 533
  year: 2016
  end-page: 545
  ident: CR59
  article-title: Experimental insights into the importance of aquatic bacterial community composition to the degradation of dissolved organic matter
  publication-title: ISME J.
  doi: 10.1038/ismej.2015.131
– volume: 66
  start-page: 153111
  year: 2020
  ident: CR58
  article-title: Phloretin ameliorates hyperuricemia-induced chronic renal dysfunction through inhibiting NLRP3 inflammasome and uric acid reabsorption
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2019.153111
– volume: 7
  start-page: 10
  year: 2017
  end-page: 17
  ident: CR2
  article-title: Mechanisms of renal fibrosis
  publication-title: Annu. Rev. Physiol.
– volume: 63
  start-page: 713
  year: 2014
  end-page: 735
  ident: CR4
  article-title: KDOQI US commentary on the 2012 KDIGO clinical practice guideline for the evaluation and management of CKD
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2014.01.416
– ident: CR61
– volume: 44
  start-page: 859
  year: 2021
  end-page: 872
  ident: CR29
  article-title: TGR5 Attenuated liver ischemia-reperfusion injury by activating the Keap1-Nrf2 signaling pathway in mice
  publication-title: Inflammation
  doi: 10.1007/s10753-020-01382-y
– volume: 9
  start-page: 1410
  year: 2014
  end-page: 1417
  ident: CR45
  article-title: Serum metabolomic profiling and incident CKD among African Americans
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.11971113
– volume: 27
  start-page: 961
  year: 1974
  end-page: 979
  ident: CR35
  article-title: Human fecal flora: the normal flora of 20 Japanese-Hawaiians
  publication-title: Appl. Microbiol.
  doi: 10.1128/am.27.5.961-979.1974
– volume: 361
  start-page: k2179
  year: 2018
  ident: CR8
  article-title: Role of the gut microbiota in nutrition and health
  publication-title: BMJ
  doi: 10.1136/bmj.k2179
– volume: 150
  start-page: 601
  year: 2013
  end-page: 608
  ident: CR33
  article-title: In vivo disposition and metabolism of madecassoside, a major bioactive constituent in Centella asiatica (L.) Urb
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2013.09.004
– volume: 35
  start-page: 2265
  year: 2012
  end-page: 2270
  ident: CR43
  article-title: Alternative markers of hyperglycemia and risk of diabetes
  publication-title: Diabetes Care
  doi: 10.2337/dc12-0787
– volume: 11
  start-page: 609060
  year: 2020
  ident: CR50
  article-title: TGR5 regulates macrophage inflammation in nonalcoholic steatohepatitis by modulating NLRP3 inflammasome Activation
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.609060
– volume: 596
  start-page: 590
  year: 2021
  end-page: 596
  ident: CR68
  article-title: Highly accurate protein structure prediction for the human proteome
  publication-title: Nature
  doi: 10.1038/s41586-021-03828-1
– volume: 2
  year: 2016
  ident: CR31
  article-title: Gut microbiota-involved mechanisms in enhancing systemic exposure of ginsenosides by coexisting polysaccharides in ginseng decoction
  publication-title: Sci. Rep.
  doi: 10.1038/srep22474
– volume: 18
  start-page: 3461
  year: 2019
  end-page: 3469
  ident: CR13
  article-title: Dysbiosis of Gram-negative gut microbiota and the associated serum lipopolysaccharide exacerbates inflammation in type 2 diabetic patients with chronic kidney disease
  publication-title: Exp. Ther. Med.
– volume: 111
  start-page: 226
  year: 2016
  end-page: 236
  ident: CR28
  article-title: TGR5 activation suppressed S1P/S1P2 signaling and resisted high glucose-induced fibrosis in glomerular mesangial cells
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.05.035
– volume: 11
  start-page: 319
  year: 2014
  end-page: 324
  ident: CR66
  article-title: Minimal, encapsulated proteomic-sample processing applied to copy-number estimation in eukaryotic cells
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2834
– volume: 7
  year: 2017
  ident: CR71
  article-title: Systemic clearance and brain distribution of carbazole-based cyanine compounds as Alzheimer’s disease drug candidates
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-16635-4
– volume: 6
  year: 2016
  ident: CR62
  article-title: An integrated lipidomics and metabolomics reveal nephroprotective effect and biochemical mechanism of Rheum officinale in chronic renal failure
  publication-title: Sci. Rep.
  doi: 10.1038/srep22151
– volume: 185
  start-page: 113262
  year: 2020
  ident: CR63
  article-title: Non-invasive urinary metabolomics reveals metabolic profiling of polycystic ovary syndrome and its subtypes
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2020.113262
– volume: 12
  start-page: 943
  year: 2014
  end-page: 951
  ident: CR54
  article-title: A LC-ESI-MS method for the simultaneous determination of madecassoside and its metabolite madecassic acid in rat plasma: comparison pharmacokinetics in normal and collagen-induced arthritic rats
  publication-title: Chin. J. Nat. Med.
– volume: 29
  start-page: 620
  year: 2008
  end-page: 625
  ident: CR17
  article-title: A microbial symbiosis factor prevents intestinal inflammatory disease
  publication-title: Nature
  doi: 10.1038/nature07008
– volume: 58
  start-page: 1648
  year: 2012
  end-page: 1655
  ident: CR44
  article-title: Associations of alternative markers of glycemia with hemoglobin A(1c) and fasting glucose
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2012.188367
– volume: 18
  start-page: 1215
  year: 2011
  end-page: 1222
  ident: CR51
  article-title: Centella asiatica in food and beverage applications and its potential antioxidant and neuroprotective effect
  publication-title: Int. Food Res. J.
– volume: 173
  start-page: 1219
  year: 2016
  end-page: 1235
  ident: CR53
  article-title: Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice through promoting the generation of hepatocyte growth factor via PPAR- in colon
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13421
– volume: 26
  start-page: 1668
  year: 2005
  end-page: 1688
  ident: CR70
  article-title: The Amber biomolecular simulation programs
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20290
– volume: 67
  start-page: 483
  year: 2016
  end-page: 498
  ident: CR14
  article-title: Role of the gut microbiome in uremia: a potential therapeutic target
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2015.09.027
– volume: 80
  start-page: 309
  year: 2018
  end-page: 326
  ident: CR3
  article-title: Mechanisms of renal fibrosis
  publication-title: Annu Rev. Physiol.
  doi: 10.1146/annurev-physiol-022516-034227
– volume: 29
  start-page: 2432
  year: 2006
  end-page: 2435
  ident: CR32
  article-title: Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.29.2432
– volume: 47
  start-page: 346
  year: 2013
  end-page: 356
  ident: CR23
  article-title: Oxidative stress in patients with cardiovascular disease and chronic renal failure
  publication-title: Free Radic. Res.
  doi: 10.3109/10715762.2013.779373
– volume: 27
  start-page: 1362
  year: 2016
  end-page: 1378
  ident: CR48
  article-title: G protein-coupled bile acid receptor TGR5 activation inhibits kidney disease in obesity and diabetes
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2014121271
– volume: 10
  start-page: 300
  year: 2018
  ident: CR11
  article-title: Impact of altered intestinal microbiota on chronic kidney disease progression
  publication-title: Toxins
  doi: 10.3390/toxins10070300
– volume: 262
  start-page: 416
  year: 1993
  end-page: 419
  ident: CR16
  article-title: Structural features of polysaccharides that induce intra-abdominal abscesses
  publication-title: Science
  doi: 10.1126/science.8211161
– volume: 1864
  start-page: 1319
  year: 2018
  end-page: 1325
  ident: CR47
  article-title: Bile acid receptors in the biliary tree: TGR5 in physiology and disease
  publication-title: Biochim Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2017.08.021
– volume: 14
  start-page: 442
  year: 2018
  end-page: 456
  ident: CR9
  article-title: The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-018-0018-2
– volume: 5
  year: 2015
  ident: CR52
  article-title: Protective effects of madecassoside against doxorubicin induced nephrotoxicity in vivo and in vitro
  publication-title: Sci. Rep.
  doi: 10.1038/srep18314
– volume: 369
  start-page: 1426
  year: 2020
  end-page: 1427
  ident: CR6
  article-title: The gut microbiota in kidney disease
  publication-title: Science
  doi: 10.1126/science.abd8344
– volume: 54
  start-page: 1263
  year: 2011
  end-page: 1272
  ident: CR27
  article-title: The bile acid membrane receptor TGR5 as an emerging target in metabolism and inflammation
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.12.004
– volume: 3
  start-page: 487
  year: 2010
  end-page: 495
  ident: CR36
  article-title: A polysaccharide from the human commensal Bacteroides fragilis protects against CNS demyelinating disease
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2010.29
– volume: 42
  start-page: 123
  year: 2019
  end-page: 140
  ident: CR12
  article-title: Gut microbiota and inflammation in chronic kidney disease and their roles in the development of cardiovascular disease
  publication-title: Hypertens. Res.
  doi: 10.1038/s41440-018-0144-z
– volume: 155
  start-page: 1451
  year: 2013
  end-page: 1463
  ident: CR19
  article-title: Microbiota modulate behavioral and physiological abnormalities associated with neurodevelopmental disorders
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.024
– volume: 23
  year: 2015
  ident: CR30
  article-title: Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8489
– volume: 19
  start-page: 41
  year: 2004
  end-page: 47
  ident: CR46
  article-title: Decreased expression of glucose and peptide transporters in rat remnant kidney
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.19.41
– volume: 28
  start-page: 1224
  year: 2014
  end-page: 1231
  ident: CR55
  article-title: Madecassoside ameliorates bleomycin-induced pulmonary fibrosis in mice by downregulating collagen deposition
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.5120
– volume: 74
  start-page: 1279
  year: 2019
  end-page: 1293
  ident: CR56
  article-title: Guidelines for transparency on gut microbiome studies in essential and experimental hypertension
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.119.13079
– volume: 76
  start-page: 4961
  year: 2019
  end-page: 4978
  ident: CR60
  article-title: Microbiome-metabolomics reveals gut microbiota associated with glycine-conjugated metabolites and polyamine metabolism in chronic kidney disease
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-019-03155-9
– volume: 83
  start-page: 308
  year: 2013
  end-page: 315
  ident: CR10
  article-title: Chronic kidney disease alters intestinal microbial flora
  publication-title: Kidney Int.
  doi: 10.1038/ki.2012.345
– volume: 10
  start-page: e02566
  year: 2019
  ident: CR15
  article-title: Dynamics of human gut microbiota and short-chain fatty acids in response to dietary interventions with three fermentable fibers
  publication-title: mBio
  doi: 10.1128/mBio.02566-18
– volume: 122
  start-page: 107
  year: 2005
  end-page: 118
  ident: CR37
  article-title: An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system
  publication-title: Cell
  doi: 10.1016/j.cell.2005.05.007
– volume: 186
  start-page: 952
  year: 2017
  end-page: 960
  ident: CR26
  article-title: Serum levels of 1,5-anhydroglucitol and risk of incident end-stage renal disease
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx167
– volume: 16
  year: 2020
  ident: CR64
  article-title: Serum metabolomics reveals metabolic profiling for women with hyperandrogenism and insulin resistance in polycystic ovary syndrome
  publication-title: Metabolomics
  doi: 10.1007/s11306-020-1642-y
– volume: 472
  start-page: 149
  year: 1999
  end-page: 158
  ident: CR21
  article-title: Short-chain fatty acid in the human colon. Relation to inflammatory bowel diseases and colon cancer
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4757-3230-6_13
– volume: 25
  start-page: 6758
  year: 2006
  end-page: 6780
  ident: CR40
  article-title: NF-κB and the immune response
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209943
– volume: 19
  start-page: 1639
  year: 1998
  end-page: 1662
  ident: CR69
  article-title: Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function
  publication-title: J. Comput. Chem.
  doi: 10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B
– volume: 382
  start-page: 260
  year: 2013
  end-page: 272
  ident: CR1
  article-title: Chronic kidney disease: global dimension and perspectives
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)60687-X
– volume: 25
  start-page: 657
  year: 2013
  end-page: 670
  ident: CR34
  article-title: The gut microbiome, kidney disease, and targeted interventions
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2013080905
– volume: 9
  start-page: 3280
  year: 2010
  end-page: 3289
  ident: CR67
  article-title: Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology
  publication-title: J. Proteome Res.
  doi: 10.1021/pr1002214
– volume: 332
  start-page: 974
  year: 2011
  end-page: 977
  ident: CR38
  article-title: The Toll-like receptor 2 pathway establishes colonization by a commensal of the human microbiota
  publication-title: Science
  doi: 10.1126/science.1206095
– volume: 38
  start-page: 723
  year: 1989
  end-page: 729
  ident: CR42
  article-title: Plasma 1,5-anhydro-D-glucitol as new clinical marker of glycemic control in NIDDM patients
  publication-title: Diabetes
  doi: 10.2337/diab.38.6.723
– volume: 185
  start-page: 4101
  year: 2010
  end-page: 4108
  ident: CR39
  article-title: Central nervous system demyelinating disease protection by the human commensal Bacteroides fragilis depends on polysaccharide A expression
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001443
– volume: 35
  start-page: 281
  year: 2012
  end-page: 286
  ident: CR25
  article-title: Serum 1,5-anhydroglucitol concentrations are a reliable index of glycemic control in type 2 diabetes with mild or moderate renal dysfunction
  publication-title: Diabetes Care
  doi: 10.2337/dc11-1462
– volume: 157
  start-page: 257
  year: 2019
  end-page: 259.e255
  ident: CR65
  article-title: Tyrosine and glutamine-leucine are metabolic markers of early-stage colorectal cancers
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.020
– volume: 107
  start-page: 12204
  year: 2010
  end-page: 12209
  ident: CR18
  article-title: Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909122107
– volume: 6
  year: 2016
  ident: 33824_CR62
  publication-title: Sci. Rep.
  doi: 10.1038/srep22151
– volume: 262
  start-page: 416
  year: 1993
  ident: 33824_CR16
  publication-title: Science
  doi: 10.1126/science.8211161
– volume: 66
  start-page: 153111
  year: 2020
  ident: 33824_CR58
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2019.153111
– volume: 369
  start-page: 1426
  year: 2020
  ident: 33824_CR6
  publication-title: Science
  doi: 10.1126/science.abd8344
– volume: 25
  start-page: 657
  year: 2013
  ident: 33824_CR34
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2013080905
– volume: 173
  start-page: 1219
  year: 2016
  ident: 33824_CR53
  publication-title: Br. J. Pharmacol.
  doi: 10.1111/bph.13421
– volume: 10
  start-page: 300
  year: 2018
  ident: 33824_CR11
  publication-title: Toxins
  doi: 10.3390/toxins10070300
– volume: 101
  start-page: 8687
  year: 2004
  ident: 33824_CR57
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0400035101
– ident: 33824_CR61
  doi: 10.1038/s41401-022-00898-3
– volume: 185
  start-page: 4101
  year: 2010
  ident: 33824_CR39
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1001443
– volume: 9
  start-page: 3280
  year: 2010
  ident: 33824_CR67
  publication-title: J. Proteome Res.
  doi: 10.1021/pr1002214
– volume: 76
  start-page: 4961
  year: 2019
  ident: 33824_CR60
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-019-03155-9
– volume: 7
  year: 2017
  ident: 33824_CR71
  publication-title: Sci. Rep.
  doi: 10.1038/s41598-017-16635-4
– volume: 29
  start-page: 2432
  year: 2006
  ident: 33824_CR32
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.29.2432
– volume: 29
  start-page: 620
  year: 2008
  ident: 33824_CR17
  publication-title: Nature
  doi: 10.1038/nature07008
– volume: 54
  start-page: 1421
  year: 2011
  ident: 33824_CR49
  publication-title: Hepatology
  doi: 10.1002/hep.24525
– volume: 42
  start-page: 123
  year: 2019
  ident: 33824_CR12
  publication-title: Hypertens. Res.
  doi: 10.1038/s41440-018-0144-z
– volume: 155
  start-page: 1451
  year: 2013
  ident: 33824_CR19
  publication-title: Cell
  doi: 10.1016/j.cell.2013.11.024
– volume: 26
  start-page: 1668
  year: 2005
  ident: 33824_CR70
  publication-title: J. Comput. Chem.
  doi: 10.1002/jcc.20290
– volume: 7
  start-page: 10
  year: 2017
  ident: 33824_CR2
  publication-title: Annu. Rev. Physiol.
– volume: 27
  start-page: 1362
  year: 2016
  ident: 33824_CR48
  publication-title: J. Am. Soc. Nephrol.
  doi: 10.1681/ASN.2014121271
– volume: 382
  start-page: 260
  year: 2013
  ident: 33824_CR1
  publication-title: Lancet
  doi: 10.1016/S0140-6736(13)60687-X
– volume: 185
  start-page: 113262
  year: 2020
  ident: 33824_CR63
  publication-title: J. Pharm. Biomed. Anal.
  doi: 10.1016/j.jpba.2020.113262
– volume: 150
  start-page: 601
  year: 2013
  ident: 33824_CR33
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2013.09.004
– volume: 14
  start-page: 442
  year: 2018
  ident: 33824_CR9
  publication-title: Nat. Rev. Nephrol.
  doi: 10.1038/s41581-018-0018-2
– volume: 38
  start-page: 723
  year: 1989
  ident: 33824_CR42
  publication-title: Diabetes
  doi: 10.2337/diab.38.6.723
– volume: 25
  start-page: 368
  year: 2015
  ident: 33824_CR20
  publication-title: Glycobiology
  doi: 10.1093/glycob/cwu117
– volume: 472
  start-page: 149
  year: 1999
  ident: 33824_CR21
  publication-title: Adv. Exp. Med. Biol.
  doi: 10.1007/978-1-4757-3230-6_13
– volume: 18
  start-page: 3461
  year: 2019
  ident: 33824_CR13
  publication-title: Exp. Ther. Med.
– volume: 9
  start-page: 1410
  year: 2014
  ident: 33824_CR45
  publication-title: Clin. J. Am. Soc. Nephrol.
  doi: 10.2215/CJN.11971113
– volume: 47
  start-page: 346
  year: 2013
  ident: 33824_CR23
  publication-title: Free Radic. Res.
  doi: 10.3109/10715762.2013.779373
– volume: 11
  start-page: 319
  year: 2014
  ident: 33824_CR66
  publication-title: Nat. Methods
  doi: 10.1038/nmeth.2834
– volume: 361
  start-page: k2179
  year: 2018
  ident: 33824_CR8
  publication-title: BMJ
  doi: 10.1136/bmj.k2179
– volume: 74
  start-page: 1279
  year: 2019
  ident: 33824_CR56
  publication-title: Hypertension
  doi: 10.1161/HYPERTENSIONAHA.119.13079
– volume: 19
  start-page: 41
  year: 2004
  ident: 33824_CR46
  publication-title: Drug Metab. Pharmacokinet.
  doi: 10.2133/dmpk.19.41
– volume: 41
  start-page: 373
  year: 2020
  ident: 33824_CR22
  publication-title: Acta Pharmacol. Sin.
  doi: 10.1038/s41401-019-0319-4
– volume: 10
  start-page: 533
  year: 2016
  ident: 33824_CR59
  publication-title: ISME J.
  doi: 10.1038/ismej.2015.131
– volume: 23
  start-page: 859
  year: 2017
  ident: 33824_CR24
  publication-title: Nat. Med.
  doi: 10.1038/nm.4358
– volume: 3
  start-page: 487
  year: 2010
  ident: 33824_CR36
  publication-title: Mucosal Immunol.
  doi: 10.1038/mi.2010.29
– volume: 11
  start-page: 609060
  year: 2020
  ident: 33824_CR50
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2020.609060
– volume: 80
  start-page: 309
  year: 2018
  ident: 33824_CR3
  publication-title: Annu Rev. Physiol.
  doi: 10.1146/annurev-physiol-022516-034227
– volume: 25
  start-page: 6758
  year: 2006
  ident: 33824_CR40
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1209943
– volume: 332
  start-page: 974
  year: 2011
  ident: 33824_CR38
  publication-title: Science
  doi: 10.1126/science.1206095
– volume: 596
  start-page: 590
  year: 2021
  ident: 33824_CR68
  publication-title: Nature
  doi: 10.1038/s41586-021-03828-1
– volume: 35
  start-page: 2265
  year: 2012
  ident: 33824_CR43
  publication-title: Diabetes Care
  doi: 10.2337/dc12-0787
– volume: 67
  start-page: 483
  year: 2016
  ident: 33824_CR14
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2015.09.027
– volume: 186
  start-page: 952
  year: 2017
  ident: 33824_CR26
  publication-title: Am. J. Epidemiol.
  doi: 10.1093/aje/kwx167
– volume: 27
  start-page: 961
  year: 1974
  ident: 33824_CR35
  publication-title: Appl. Microbiol.
  doi: 10.1128/am.27.5.961-979.1974
– volume: 18
  start-page: 1215
  year: 2011
  ident: 33824_CR51
  publication-title: Int. Food Res. J.
– volume: 1864
  start-page: 1319
  year: 2018
  ident: 33824_CR47
  publication-title: Biochim Biophys. Acta Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2017.08.021
– volume: 111
  start-page: 226
  year: 2016
  ident: 33824_CR28
  publication-title: Pharmacol. Res.
  doi: 10.1016/j.phrs.2016.05.035
– volume: 2
  year: 2016
  ident: 33824_CR31
  publication-title: Sci. Rep.
  doi: 10.1038/srep22474
– volume: 157
  start-page: 257
  year: 2019
  ident: 33824_CR65
  publication-title: Gastroenterology
  doi: 10.1053/j.gastro.2019.03.020
– volume: 35
  start-page: 281
  year: 2012
  ident: 33824_CR25
  publication-title: Diabetes Care
  doi: 10.2337/dc11-1462
– volume: 81
  start-page: 351
  year: 2012
  ident: 33824_CR5
  publication-title: Kidney Int.
  doi: 10.1038/ki.2011.380
– volume: 464
  start-page: 59
  year: 2010
  ident: 33824_CR7
  publication-title: Nature
  doi: 10.1038/nature08821
– volume: 63
  start-page: 713
  year: 2014
  ident: 33824_CR4
  publication-title: Am. J. Kidney Dis.
  doi: 10.1053/j.ajkd.2014.01.416
– volume: 263
  start-page: E268
  year: 1992
  ident: 33824_CR41
  publication-title: Am. J. Physiol.
– volume: 54
  start-page: 1263
  year: 2011
  ident: 33824_CR27
  publication-title: J. Hepatol.
  doi: 10.1016/j.jhep.2010.12.004
– volume: 44
  start-page: 859
  year: 2021
  ident: 33824_CR29
  publication-title: Inflammation
  doi: 10.1007/s10753-020-01382-y
– volume: 107
  start-page: 12204
  year: 2010
  ident: 33824_CR18
  publication-title: Proc. Natl Acad. Sci. USA
  doi: 10.1073/pnas.0909122107
– volume: 23
  year: 2015
  ident: 33824_CR30
  publication-title: Nat. Commun.
  doi: 10.1038/ncomms8489
– volume: 83
  start-page: 308
  year: 2013
  ident: 33824_CR10
  publication-title: Kidney Int.
  doi: 10.1038/ki.2012.345
– volume: 19
  start-page: 1639
  year: 1998
  ident: 33824_CR69
  publication-title: J. Comput. Chem.
  doi: 10.1002/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B
– volume: 58
  start-page: 1648
  year: 2012
  ident: 33824_CR44
  publication-title: Clin. Chem.
  doi: 10.1373/clinchem.2012.188367
– volume: 10
  start-page: e02566
  year: 2019
  ident: 33824_CR15
  publication-title: mBio
  doi: 10.1128/mBio.02566-18
– volume: 5
  year: 2015
  ident: 33824_CR52
  publication-title: Sci. Rep.
  doi: 10.1038/srep18314
– volume: 12
  start-page: 943
  year: 2014
  ident: 33824_CR54
  publication-title: Chin. J. Nat. Med.
– volume: 28
  start-page: 1224
  year: 2014
  ident: 33824_CR55
  publication-title: Phytother. Res.
  doi: 10.1002/ptr.5120
– volume: 16
  year: 2020
  ident: 33824_CR64
  publication-title: Metabolomics
  doi: 10.1007/s11306-020-1642-y
– volume: 122
  start-page: 107
  year: 2005
  ident: 33824_CR37
  publication-title: Cell
  doi: 10.1016/j.cell.2005.05.007
SSID ssj0000391844
Score 2.599937
Snippet Renal fibrosis is an inevitable outcome of various manifestations of progressive chronic kidney diseases (CKD). The need for efficacious treatment regimen...
Renal fibrosis is the main pathological feature of chronic kidney disease (CKD). Here, the authors show that live B. fragilis can attenuate renal fibrosis via...
SourceID doaj
pubmedcentral
proquest
pubmed
crossref
springer
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 6081
SubjectTerms 13
38/77
631/326/2565/2134
64/60
692/699/1585/3182
82/58
Adenine
Adenine - metabolism
Animal models
Animals
Attenuation
Bacteroides fragilis
Biological Products - metabolism
Disease Models, Animal
Fibrosis
Gastrointestinal Microbiome
Humanities and Social Sciences
Inflammation
Kidney - metabolism
Kidney diseases
Kidney Diseases - pathology
Kidneys
Lipopolysaccharides
Lipopolysaccharides - metabolism
Lipopolysaccharides - toxicity
Metabolomics
Mice
Microorganisms
multidisciplinary
Natural products
Oral administration
Oxidation
Oxidative stress
Proteomics
Reabsorption
Renal Insufficiency, Chronic - pathology
Science
Science (multidisciplinary)
Sodium-Glucose Transporter 2 - metabolism
Substrates
Ureteral Obstruction - metabolism
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwEB5VlZB6qSgUCC0oSNwgquM4dnKkiFIhwamVerP8bCNts2ize-DfM-Nkl27L48I1niTWPDwzmvE3AG9tkBZzH1eYkjUFWqJDm4umMHRcEr6dTGj7X7_J80vx5aq-ujPqi3rCRnjgkXEnyjZRquDR7VbCNsw0MdpWRKdaw7xL6KXo8-4kU-kMrlpMXcR0S4ZVzckg0pmQmterhotCbnmiBNj_uyjzYbPkvYppckRnj2F_iiDzD-POD2An9E_g0ThT8sdT-IyCz69Xy_yWWu1syE8THvO882HI48Jcd7NuyM1tmNHlfAw080Wg70XMm-cDLnU9vRoO4fLs08XH82KallA4jLqWhfXSt4YKq9KpqJSJLYt16a1ouPHBGhGUlIJ5xdDULNVxS1e6gKSeudZXz2C3n_fhBeQUQ8ZYM1tTQMekrVpLuG285sbUMmZQrjmn3QQlThMtZjqVtKtGj9zWyG2duK1lBu8273wfgTT-Sn1KAtlQEgh2eoCqoSfV0P9SjQyO1-LUk2UOmisuFKZtXGXwZrOMNkWFEtOH-SrR1ARozEUGz0fpb3aCDp9iWJ6B2tKLra1ur_TdTcLtppuZdYX_fb_WoF_b-jMrXv4PVhzBHifVp1YccQy7y8UqvMJoamlfJ8P5CVxnGak
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagCIkL4t20BQWJG0R1HL9yQhRRKiQ4UWlvlp9LpG1SNrsH_j0ex5tqefQa24kz47E_e8bfIPTGeG7i3sdWusayipZoo80FXWmYLoHfjie2_a_f-MUl_bJgi3zgNuawyt2cmCZqN1g4Iz8lglAR4TYR769_VpA1CryrOYXGXXQPqMsgpEssxHzGAuznktJ8VwY38nSkaWZIIeyNJLTie-tRou3_F9b8O2TyD79pWo7OH6GHGUeWHybFP0Z3fP8E3Z8yS_56ij5H9ZfL7aa8goA748uzxMo8dM6PZVjrZbfqxlJf-RVc0Y9ws1x7eF-Iu-dhjEVdD039M3R5_un7x4sq50yobMRem8o47loN7lVuRRBChxYHVjtDJdHOG0294JxiJ3A0OAPe3NrW1seqDtvWNc_RQT_0_hCVgCRDYNgwgHWYm6Y1wN5GGNGa8VCgeic5ZTOhOOS1WKnk2G6kmqStorRVkrbiBXo7t7me6DRurX0GCplrAhV2ejCslypblhJGBi68i7isoUZiLUMwLQ1WtBo7ywp0slOnyvY5qpvRVKDXc3G0LHCX6N4P21SHAa0xoQV6MWl_7klc9gHJkgKJvXGx19X9kr77kdi74X4ma-J33-1G0E23_i-Ko9v_4hg9IDCoIdSGnqCDzXrrX0a0tDGvkkn8BkhGEDI
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Journals: Open Access
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Li9RAEG7WFcGL-Da6SgRvGk06_UgOIq64LsJ6cmBvTT9nA7OJJjPg_nurOsnI6Ch4TVcnTXVV-iuq-itCXhgvDMQ-NtNFXmXgiRZ8LuhM4-8S-e1EZNs_-yJOF-zzOT8_IHO7o0mBw97QDvtJLfrV6x_fr96Bw78dr4xXbwYW3T3WpZcVZZm4Rq7DySTRUc8muB__zGUNAQ2b7s7sn7pzPkUa_33Y888Syt_yqPF4OrlNbk24Mn0_GsIdcuDbu-TG2Gny6h75BOaQLjfr9BIL8IxPjyNLc9c4P6Sh18tm1QypvvQrvLIP8DPtPb4vQDTdDTDUtDjV3yeLk49fP5xmUw-FzAIWW2fGCVdrTLcKK4OUOtR54IUzrKLaeaOZl0Kw3MkcHNBgdrewhfUg6nJbu_IBOWy71j8iKSLLEHhuOMK8XJiyNsjmRjnVmouQkGLWnLITwTj2uVipmOguKzVqW4G2VdS2Egl5uZ3zbaTX-Kf0MW7IVhKpseODrl-qydOUNFUQ0jvAaSUzVa6rEEzNgpW1zp3lCTmat1PN5qaopExCMEdlQp5vh8HTMH2iW99togxHmmPKEvJw3P3tSgAGILKlCZE7drGz1N2RtrmIbN54X5OX8N1XswX9WtbfVfH4_8SfkJsUjRxLcdgROVz3G_8U0NTaPIsu8hM-8ReQ
  priority: 102
  providerName: Scholars Portal
Title The gut microbe Bacteroides fragilis ameliorates renal fibrosis in mice
URI https://link.springer.com/article/10.1038/s41467-022-33824-6
https://www.ncbi.nlm.nih.gov/pubmed/36241632
https://www.proquest.com/docview/2724796027
https://www.proquest.com/docview/2725204824
https://pubmed.ncbi.nlm.nih.gov/PMC9568537
https://doaj.org/article/7b8f67ed15934b80a8ffb94fc79a0dc5
Volume 13
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3di9QwEB_uA8EX8dvquVTwTYttmibp4-5ye8fCHaIe7FtJmmSvsNfKdvfB_95M-iGrp-BLC82kDZOZ5pfM5BeA98ow5eY-ZSSTWETOE0vnc1ZGEn-XyG_HPNv-1TW7vKHLVbY6AjLshfFJ-57S0v-mh-ywTy31Lu1zz1NBaMSO4RSp29Gq52w-rqsg47mgtN8fE6finqoHY5Cn6r8PX_6ZJvlbrNQPQYvH8KjHjuG0a-0TODL1U3jQnSb54xlcuC4P1_tdeIdJdsqEM8_E3FTatKHdynW1qdpQ3pkNbst3EDPcGnyfdTPmpnVFVY1VzXO4WZx_m19G_TkJUenw1i5SmulcYkiVldxyLm0e2yzRigoitVGSGs4YjTWPnZMpjOAmZVIaJ6rjMtfpCzipm9q8ghDRo7VZrDKEcjFTaa6QsY1kRMqM2QCSQXNF2ZOI41kWm8IHs1NRdNounLYLr-2CBfBhrPO9o9D4p_QMO2SURPpr_6DZroveHAquhGXcaIfFUqpELIW1Kqe25LmMdZkFcDZ0Z9H7ZFsQTih3EzbCA3g3FjtvwhCJrE2z9zIZUhkTGsDLrvfHlrihHtErCYAf2MVBUw9L6urWM3bjnswsdd_9OFjQr2b9XRWv_0_8DTwkaOSYbkPP4GS33Zu3DjHt1ASO-Yq7q1hcTOB0Ol1-Xbr77Pz685eJd5-JX4tw1ysqfgI6QRS0
linkProvider Springer Nature
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYIL4k2gQJDgBFEdx7GTA0IUKFv6OLXS3oyfS6RtUja7Qv1T_EY8zqNaHr31GjuJM54Zf86Mv0HolbJM-b2PTmSKi8RbovY252QiwV0Cvx0LbPuHR2xyQr9O8-kG-jWchYG0ysEnBkdtGg3_yLcJJ5R7uE34-7MfCVSNgujqUEKjU4t9e_7Tb9nad3uf_Py-JmT38_HHSdJXFUi0RyfLRBlmSgkBSKa541y6Ers8NYoWRBqrJLWcMYoNx14lFcQ7U51q67sarEuT-edeQ9f9wovBoviUj_90gG29oLQ_m4OzYrulwROFlPmsIDRha-tfKBPwL2z7d4rmH3HasPzt3kG3e9waf-gU7S7asPU9dKOrZHl-H33x6hbPVsv4FBL8lI13Agt0Uxnbxm4hZ9W8amN5audACeDhbbyw8Dznd-tN65uqGm61D9DJlUjzIdqsm9o-RjEgV-dyrHKAkZiprFTAFkdyImXOXITSQXJC9wTmUEdjLkIgPStEJ23hpS2CtAWL0JvxnrOOvuPS3jswIWNPoN4OF5rFTPSWLLgqHOPWeByYUVVgWTinSuo0LyU2Oo_Q1jCdovcHrbjQ3gi9HJu9JUN4Rta2WYU-OdAoExqhR93sjyPxMAOQM4kQX9OLtaGut9TV98AWDudB88y_9-2gQRfD-r8onlz-FS_Qzcnx4YE42Dvaf4puEVBwSPOhW2hzuVjZZx6pLdXzYB4x-nbV9vgbA9hN8w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELZKEYgL4k2gQJDgBFETx7GTA0KUsrQUKg5U2pvr57LSNimbXaH-NX4dM06y1fLordfYSZzxzOSzZ_wNIS-04xrWPiZRWVomYIkGbM6rRKG7RH47Htj2vxzyvSP2aVyMN8iv4SwMplUOPjE4atsY3CPfpoIyAXAbluq-T4v4ujt6e_ojwQpSGGkdyml0KnLgzn7C8q19s78Lc_2S0tGHb-_3kr7CQGIAqSwSbbmtFAYjuRFeCOWr1BeZ1aykyjqtmBOcs9SKFNRTY-wzM5lx0NWmprI5PPcKuSryIkMbE2Ox2t9B5vWSsf6cTpqX2y0LXimkz-clZQlf-xeGkgH_wrl_p2v-EbMNv8LRLXKzx7Dxu07pbpMNV98h17qqlmd3yUdQvXiyXMQnmOynXbwTGKGbqXVt7OdqMp1N21iduBnSAwDUjecOn-dh5d600DSt8VZ3jxxdijTvk826qd1DEiOK9b5IdYGQMuU6rzQyx9GCKlVwH5FskJw0PZk51tSYyRBUz0vZSVuCtGWQtuQRebW657Sj8riw9w5OyKon0nCHC818InurlkKXngtnARPmTJepKr3XFfNGVCq1pojI1jCdsvcNrTzX5Ig8XzWDVWOoRtWuWYY-BVIqUxaRB93sr0YCkANRNI2IWNOLtaGut9TT74E5HM-GFjm89_WgQefD-r8oHl38Fc_IdbBE-Xn_8OAxuUFRvzHjh22RzcV86Z4AaFvop8E6YnJ82eb4G6dQUik
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+gut+microbe+Bacteroides+fragilis+ameliorates+renal+fibrosis+in+mice&rft.jtitle=Nature+communications&rft.au=Zhou%2C+Wei&rft.au=Wu%2C+Wen-hui&rft.au=Si%2C+Zi-lin&rft.au=Liu%2C+Hui-ling&rft.date=2022-10-14&rft.pub=Nature+Publishing+Group+UK&rft.eissn=2041-1723&rft.volume=13&rft.issue=1&rft_id=info:doi/10.1038%2Fs41467-022-33824-6&rft.externalDocID=10_1038_s41467_022_33824_6
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2041-1723&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2041-1723&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2041-1723&client=summon