Large-scale and high-resolution mass spectrometry-based proteomics profiling defines molecular subtypes of esophageal cancer for therapeutic targeting

• Published in: Nature communications Vol. 12; no. 1; pp. 4961 - 18
• Main Authors: Liu, Wei, Xie, Lei, He, Yao-Hui, Wu, Zhi-Yong, Liu, Lu-Xin, Bai, Xue-Feng, Deng, Dan-Xia, Xu, Xiu-E, Liao, Lian-Di, Lin, Wan, Heng, Jing-Hua, Xu, Xin, Peng, Liu, Huang, Qing-Feng, Li, Cheng-Yu, Zhang, Zhi-Da, Wang, Wei, Zhang, Guo-Rui, Gao, Xiang, Wang, Shao-Hong, Li, Chun-Quan, Xu, Li-Yan, Liu, Wen, Li, En-Min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 16.08.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13/1; 13/51; 631/337/475; 631/67/1059/153; 631/67/1857; 64/60; 82/58; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Cancer; Cell Cycle; Cohort Studies; Drug development; Drugs; Elongin - genetics; Elongin - metabolism; Esophageal cancer; Esophageal Neoplasms - genetics; Esophageal Neoplasms - metabolism; Esophagus; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humanities and Social Sciences; Humans; Mass spectrometry; Mass Spectrometry - methods; Mass spectroscopy; multidisciplinary; Patients; Prognosis; Proteins; Proteomics; Ribosomal proteins; Science; Science (multidisciplinary); Scientific imaging; Serine-Arginine Splicing Factors - genetics; Serine-Arginine Splicing Factors - metabolism; Spectroscopy; Therapeutic targets; Tumors

Esophageal cancer (EC) is a type of aggressive cancer without clinically relevant molecular subtypes, hindering the development of effective strategies for treatment. To define molecular subtypes of EC, we perform mass spectrometry-based proteomic and phosphoproteomics profiling of EC tumors and adj...