Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

• Published in: Nature communications Vol. 12; no. 1; pp. 5214 - 17
• Main Authors: Sletten, Arthur C., Davidson, Jessica W., Yagabasan, Busra, Moores, Samantha, Schwaiger-Haber, Michaela, Fujiwara, Hideji, Gale, Sarah, Jiang, Xuntian, Sidhu, Rohini, Gelman, Susan J., Zhao, Shuang, Patti, Gary J., Ory, Daniel S., Schaffer, Jean E.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/31; 13/89; 38; 38/91; 631/337/384/521; 631/45/287; 692/699/317; 96; Animals; Apoptosis; Cell death; Cell Death - drug effects; CHO Cells; Cricetulus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2 - metabolism; Dyslipidemia; Fatty liver; Fatty Liver - drug therapy; Fatty Liver - genetics; Fatty Liver - metabolism; Homeostasis; Humanities and Social Sciences; Inflammation; Lipid Metabolism; Lipids; Lipids - pharmacology; Male; Metabolic disorders; Metabolic syndrome; Metabolic Syndrome - metabolism; Metabolism; Mice; Mice, Inbred C57BL; multidisciplinary; Nucleoli; Oxidation resistance; Oxidative metabolism; Oxidative stress; Oxidative Stress - drug effects; Protective Agents - pharmacology; Rapamycin; Ribonucleic acid; RNA; RNA, Long Noncoding; RNA, Small Nucleolar - genetics; RNA, Small Nucleolar - metabolism; Science; Science (multidisciplinary); Signal Transduction - drug effects; snoRNA; Steatosis; TOR protein

Dyslipidemia and resulting lipotoxicity are pathologic signatures of metabolic syndrome and type 2 diabetes. Excess lipid causes cell dysfunction and induces cell death through pleiotropic mechanisms that link to oxidative stress. However, pathways that regulate the response to metabolic stress are...