Downregulation of METTL14 improves postmenopausal osteoporosis via IGF2BP1 dependent posttranscriptional silencing of SMAD1

• Published in: Cell death & disease Vol. 13; no. 11; pp. 919 - 12
• Main Authors: Huang, Chaoqing, Wang, Yuan
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2022; Springer Nature B.V; Nature Publishing Group
• Subjects: 13; 38/89; 631/67; 631/80; Animals; Antibodies; Biochemistry; Biomedical and Life Sciences; Bone mass; Cell Biology; Cell Culture; Cell Differentiation; Cell proliferation; Cells, Cultured; Cholecystokinin; Computed tomography; Down-Regulation; Female; Fractures; Humans; Immunology; Insulin-like growth factor-binding protein 1; Life Sciences; Mesenchymal Stem Cells - metabolism; Methylation; Methyltransferases - metabolism; Mice; MicroRNAs - metabolism; Mineralization; N6-methyladenosine; Osteoblastogenesis; Osteogenesis; Osteoporosis; Osteoporosis - metabolism; Osteoporosis, Postmenopausal; Ovariectomy; Post-menopause; Post-transcription; Smad1 Protein - metabolism; X-Ray Microtomography

Osteoporosis (OP) tends to occur in postmenopausal women, making them prone to fractures. N 6-methyladenosine (m6A) methylation plays a crucial role in OP. Herein, we aimed to explore the effects of METTL14 on osteogenesis and the underlying mechanism. Osteogenic differentiation was assessed through...